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Title: Microdosimetric investigations at the fast neutron therapy facility at Fermilab

Abstract

Microdosimetry was used to investigate three issues at the neutron therapy facility (NTF) at Fermilab. Firstly, the conversion factor from absorbed dose in A-150 tissue equivalent plastic to absorbed dose in ICRU tissue was determined. For this, the effective neutron kerma factor ratios, i.e., oxygen tissue equivalent plastic and carbon to A-150 tissue equivalent plastic, were measured in the neutron beam. An A-150 tissue equivalent plastic to ICRU tissue absorbed dose conversion factor of 0.92 {+-} 0.04 was determined. Secondly, variations in the radiobiological effectiveness (RBE) in the beam were mapped by determining variations in two related quantities, e{sup *} and R, with field size and depth in tissue. Maximal variation in e{sup *} and R of 9% and 15% respectively were determined. Lastly, the feasibility of utilizing the boron neutron capture reaction on boron-10 to selectively enhance the tumor dose in the NTF beam was investigated.

Authors:
Publication Date:
Research Org.:
University of Wisconsin - Madison, Department of Medical Physics, Madison, WI (US)
Sponsoring Org.:
USDOE Office of Energy Research (ER) (US)
OSTI Identifier:
3483
Report Number(s):
DOE/CH/03000-T28
TRN: US0101405
DOE Contract Number:  
AC02-76CH03000
Resource Type:
Technical Report
Resource Relation:
Other Information: Thesis (Ph.D.); PBD: 1 Dec 1997
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BORON 10; FAST NEUTRONS; FERMILAB; NEOPLASMS; NEUTRON BEAMS; NEUTRON REACTIONS; NEUTRON THERAPY; RADIATION DOSES; MICRODOSIMETRY; NEUTRON CAPTURE THERAPY; KERMA; PLASTICS; ANIMAL TISSUES; DOSE EQUIVALENTS

Citation Formats

Langen, K.M.. Microdosimetric investigations at the fast neutron therapy facility at Fermilab. United States: N. p., 1997. Web. doi:10.2172/3483.
Langen, K.M.. Microdosimetric investigations at the fast neutron therapy facility at Fermilab. United States. doi:10.2172/3483.
Langen, K.M.. Mon . "Microdosimetric investigations at the fast neutron therapy facility at Fermilab". United States. doi:10.2172/3483. https://www.osti.gov/servlets/purl/3483.
@article{osti_3483,
title = {Microdosimetric investigations at the fast neutron therapy facility at Fermilab},
author = {Langen, K.M.},
abstractNote = {Microdosimetry was used to investigate three issues at the neutron therapy facility (NTF) at Fermilab. Firstly, the conversion factor from absorbed dose in A-150 tissue equivalent plastic to absorbed dose in ICRU tissue was determined. For this, the effective neutron kerma factor ratios, i.e., oxygen tissue equivalent plastic and carbon to A-150 tissue equivalent plastic, were measured in the neutron beam. An A-150 tissue equivalent plastic to ICRU tissue absorbed dose conversion factor of 0.92 {+-} 0.04 was determined. Secondly, variations in the radiobiological effectiveness (RBE) in the beam were mapped by determining variations in two related quantities, e{sup *} and R, with field size and depth in tissue. Maximal variation in e{sup *} and R of 9% and 15% respectively were determined. Lastly, the feasibility of utilizing the boron neutron capture reaction on boron-10 to selectively enhance the tumor dose in the NTF beam was investigated.},
doi = {10.2172/3483},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Mon Dec 01 00:00:00 EST 1997},
month = {Mon Dec 01 00:00:00 EST 1997}
}

Technical Report:

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