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Title: Detection of gastrointestinal cancer by elastic scattering and absorption spectroscopies with the Los Alamos Optical Biopsy System

Abstract

The Los Alamos National Laboratory has continued the development of the Optical Biopsy System (OBS) for noninvasive, real-time in situ diagnosis of tissue pathologies. In proceedings of earlier SPIE conferences we reported on clinical measurements in the bladder, and we report here on recent results of clinical tests in the gastrointestinal tract. With the OBS, tissue pathologies are detected/diagnosed using spectral measurements of the elastic optical transport properties (scattering and absorption) of the tissue over a wide range of wavelengths. The use of elastic scattering as the key to optical tissue diagnostics in the OBS is based on the fact that many tissue pathologies, including a majority of cancer forms, exhibit significant architectural changes at the cellular and sub-cellular level. Since the cellular components that cause elastic scattering have dimensions typically on the order of visible to near-IR wavelengths, the elastic (Mie) scattering properties will be wavelength dependent. Thus, morphology and size changes can be expected to cause significant changes m an optical signature that is derived from the wavelength-dependence of elastic scattering. Additionally, the optical geometry of the OBS beneficially enhances its sensitivity for measuring absorption bands. The OBS employs a small fiber-optic probe that is amenable to usemore » with any endoscope or catheter, or to direct surface examination, as well as interstitial needle insertion. Data acquistion/display time is <1 second.« less

Authors:
; ; ; ;  [1];  [2];  [3]
  1. Los Alamos National Lab., NM (United States)
  2. Wisconsin Medical School, Milwaukee, WI (United States). Dept. of Gastroenterology
  3. Univ. of Oklahoma Medical School, Oklahoma City, OK (United States). Dept. of Gastroenterology
Publication Date:
Research Org.:
Los Alamos National Lab., NM (United States)
Sponsoring Org.:
USDOE, Washington, DC (United States)
OSTI Identifier:
31692
Report Number(s):
LA-UR-95-479; CONF-950226-18
ON: DE95007878
DOE Contract Number:  
W-7405-ENG-36
Resource Type:
Conference
Resource Relation:
Conference: SPIE `95: SPIE conference on optics, electro-optics, and laser application in science, engineering and medicine, San Jose, CA (United States), 5-14 Feb 1995; Other Information: PBD: [1995]
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; NEOPLASMS; DIAGNOSIS; TISSUES; THERAPY; BIOPSY; GASTROINTESTINAL TRACT; ELASTIC SCATTERING; RAMAN SPECTROSCOPY; DIAGNOSTIC TECHNIQUES; MEDICINE

Citation Formats

Mourant, J.R., Boyer, J., Johnson, T.M., Lacey, J., Bigio, I.J., Bohorfoush, A., and Mellow, M. Detection of gastrointestinal cancer by elastic scattering and absorption spectroscopies with the Los Alamos Optical Biopsy System. United States: N. p., 1995. Web.
Mourant, J.R., Boyer, J., Johnson, T.M., Lacey, J., Bigio, I.J., Bohorfoush, A., & Mellow, M. Detection of gastrointestinal cancer by elastic scattering and absorption spectroscopies with the Los Alamos Optical Biopsy System. United States.
Mourant, J.R., Boyer, J., Johnson, T.M., Lacey, J., Bigio, I.J., Bohorfoush, A., and Mellow, M. Wed . "Detection of gastrointestinal cancer by elastic scattering and absorption spectroscopies with the Los Alamos Optical Biopsy System". United States. https://www.osti.gov/servlets/purl/31692.
@article{osti_31692,
title = {Detection of gastrointestinal cancer by elastic scattering and absorption spectroscopies with the Los Alamos Optical Biopsy System},
author = {Mourant, J.R. and Boyer, J. and Johnson, T.M. and Lacey, J. and Bigio, I.J. and Bohorfoush, A. and Mellow, M.},
abstractNote = {The Los Alamos National Laboratory has continued the development of the Optical Biopsy System (OBS) for noninvasive, real-time in situ diagnosis of tissue pathologies. In proceedings of earlier SPIE conferences we reported on clinical measurements in the bladder, and we report here on recent results of clinical tests in the gastrointestinal tract. With the OBS, tissue pathologies are detected/diagnosed using spectral measurements of the elastic optical transport properties (scattering and absorption) of the tissue over a wide range of wavelengths. The use of elastic scattering as the key to optical tissue diagnostics in the OBS is based on the fact that many tissue pathologies, including a majority of cancer forms, exhibit significant architectural changes at the cellular and sub-cellular level. Since the cellular components that cause elastic scattering have dimensions typically on the order of visible to near-IR wavelengths, the elastic (Mie) scattering properties will be wavelength dependent. Thus, morphology and size changes can be expected to cause significant changes m an optical signature that is derived from the wavelength-dependence of elastic scattering. Additionally, the optical geometry of the OBS beneficially enhances its sensitivity for measuring absorption bands. The OBS employs a small fiber-optic probe that is amenable to use with any endoscope or catheter, or to direct surface examination, as well as interstitial needle insertion. Data acquistion/display time is <1 second.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Wed Mar 01 00:00:00 EST 1995},
month = {Wed Mar 01 00:00:00 EST 1995}
}

Conference:
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