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Title: Evaluation of the exon predictions of the GRAIL software

Abstract

Identification of transcribed sequences within genomic regions has been a major rate-limiting step in the pursuit of genes. The authors have tested the ability of GRAIL 1 and GRAIL 2 to locate coding exons in the 41 longest human genomic sequences available in release 38 of the EMBL database. Of the total annotated exons GRAIL 1 correctly identified 68% of coding exons. GRAIL 2 correctly identified 71%. Of the 686 predictions made by GRAIL 1, 46.4% did not correspond to an annotated exon. The corresponding figures for GRAIL 2 were 556 and 30.5%. The GRAIL 2 software predicted as excellent a significantly higher proportion of the coding exons than did GRAIL 1, and also gave a significantly lower figure for false predictions. GRAIL 2 thus represents a significant improvement over GRAIL 1. 10 refs., 1 fig., 1 tab.

Authors:
; ;  [1]
  1. Univ. of Oslo (Norway)
Publication Date:
OSTI Identifier:
255223
Resource Type:
Journal Article
Journal Name:
Genomics
Additional Journal Information:
Journal Volume: 24; Journal Issue: 1; Other Information: PBD: 1 Nov 1994
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; 99 MATHEMATICS, COMPUTERS, INFORMATION SCIENCE, MANAGEMENT, LAW, MISCELLANEOUS; ALGORITHMS; COMPARATIVE EVALUATIONS; GENETIC MAPPING; GENES; FORECASTING; IDENTIFICATION SYSTEMS; TRANSCRIPTION

Citation Formats

Lopez, R, Larsen, F, and Prydz, H. Evaluation of the exon predictions of the GRAIL software. United States: N. p., 1994. Web. doi:10.1006/geno.1994.1590.
Lopez, R, Larsen, F, & Prydz, H. Evaluation of the exon predictions of the GRAIL software. United States. https://doi.org/10.1006/geno.1994.1590
Lopez, R, Larsen, F, and Prydz, H. Tue . "Evaluation of the exon predictions of the GRAIL software". United States. https://doi.org/10.1006/geno.1994.1590.
@article{osti_255223,
title = {Evaluation of the exon predictions of the GRAIL software},
author = {Lopez, R and Larsen, F and Prydz, H},
abstractNote = {Identification of transcribed sequences within genomic regions has been a major rate-limiting step in the pursuit of genes. The authors have tested the ability of GRAIL 1 and GRAIL 2 to locate coding exons in the 41 longest human genomic sequences available in release 38 of the EMBL database. Of the total annotated exons GRAIL 1 correctly identified 68% of coding exons. GRAIL 2 correctly identified 71%. Of the 686 predictions made by GRAIL 1, 46.4% did not correspond to an annotated exon. The corresponding figures for GRAIL 2 were 556 and 30.5%. The GRAIL 2 software predicted as excellent a significantly higher proportion of the coding exons than did GRAIL 1, and also gave a significantly lower figure for false predictions. GRAIL 2 thus represents a significant improvement over GRAIL 1. 10 refs., 1 fig., 1 tab.},
doi = {10.1006/geno.1994.1590},
url = {https://www.osti.gov/biblio/255223}, journal = {Genomics},
number = 1,
volume = 24,
place = {United States},
year = {1994},
month = {11}
}