Evaluation of the exon predictions of the GRAIL software

doi:https://doi.org/10.1006/geno.1994.1590

Title: Evaluation of the exon predictions of the GRAIL software

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Abstract

Identification of transcribed sequences within genomic regions has been a major rate-limiting step in the pursuit of genes. The authors have tested the ability of GRAIL 1 and GRAIL 2 to locate coding exons in the 41 longest human genomic sequences available in release 38 of the EMBL database. Of the total annotated exons GRAIL 1 correctly identified 68% of coding exons. GRAIL 2 correctly identified 71%. Of the 686 predictions made by GRAIL 1, 46.4% did not correspond to an annotated exon. The corresponding figures for GRAIL 2 were 556 and 30.5%. The GRAIL 2 software predicted as excellent a significantly higher proportion of the coding exons than did GRAIL 1, and also gave a significantly lower figure for false predictions. GRAIL 2 thus represents a significant improvement over GRAIL 1. 10 refs., 1 fig., 1 tab.

Authors:

Lopez, R; Larsen, F; Prydz, H ^[1]

Univ. of Oslo (Norway)

Publication Date:: 1994-11-01

OSTI Identifier:: 255223

Resource Type:: Journal Article

Journal Name:: Genomics

Additional Journal Information:: Journal Volume: 24; Journal Issue: 1; Other Information: PBD: 1 Nov 1994

Country of Publication:: United States

Language:: English

Subject:: 55 BIOLOGY AND MEDICINE, BASIC STUDIES; 99 MATHEMATICS, COMPUTERS, INFORMATION SCIENCE, MANAGEMENT, LAW, MISCELLANEOUS; ALGORITHMS; COMPARATIVE EVALUATIONS; GENETIC MAPPING; GENES; FORECASTING; IDENTIFICATION SYSTEMS; TRANSCRIPTION

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                    Lopez, R, Larsen, F, and Prydz, H. Evaluation of the exon predictions of the GRAIL software.  United States: N. p., 1994. 
        Web.  doi:10.1006/geno.1994.1590.

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                    Lopez, R, Larsen, F, & Prydz, H. Evaluation of the exon predictions of the GRAIL software.  United States.  https://doi.org/10.1006/geno.1994.1590

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                    Lopez, R, Larsen, F, and Prydz, H. Tue .  
        "Evaluation of the exon predictions of the GRAIL software".  United States.  https://doi.org/10.1006/geno.1994.1590.

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@article{osti_255223,

  title        = {Evaluation of the exon predictions of the GRAIL software},

  author       = {Lopez, R and Larsen, F and Prydz, H},

  abstractNote = {Identification of transcribed sequences within genomic regions has been a major rate-limiting step in the pursuit of genes. The authors have tested the ability of GRAIL 1 and GRAIL 2 to locate coding exons in the 41 longest human genomic sequences available in release 38 of the EMBL database. Of the total annotated exons GRAIL 1 correctly identified 68% of coding exons. GRAIL 2 correctly identified 71%. Of the 686 predictions made by GRAIL 1, 46.4% did not correspond to an annotated exon. The corresponding figures for GRAIL 2 were 556 and 30.5%. The GRAIL 2 software predicted as excellent a significantly higher proportion of the coding exons than did GRAIL 1, and also gave a significantly lower figure for false predictions. GRAIL 2 thus represents a significant improvement over GRAIL 1. 10 refs., 1 fig., 1 tab.},

  doi          = {10.1006/geno.1994.1590},

  url          = {https://www.osti.gov/biblio/255223},
  journal      = {Genomics},
number       = 1,

  volume       = 24,

  place        = {United States},

  year         = {1994},

  month        = {11}

}

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