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Title: Application of a canine {sup 238}Pu biokinetics/dosimetry model to human bioassay data

Abstract

Associated with the use of {sup 238}Pu in thermoelectric power sources for space probes is the potential for human exposure, primarily by inhalation and most likely as {sup 238}PuO{sub 2}. Several models have been developed for assessing the level of intake and predicting the resulting radiation dose following human exposure to {sup 239}Pu. However, there are indications that existing models do not adequately describe the disposition and dosimetry of {sup 239}Pu following human exposure. In this study, a canine model that accounts for these differences has been adapted for use with human excretion data. The model is based on existing knowledge about organ retention of plutonium. An analysis of the sensitivity of the model to changes in aerosol-associated properties indicated that predictions of urinary excretion are most sensitive to changes in particle solubility and diameter and in the ratio of fragment:particle surface area. Application of the model to urinary excretion data from seven workers exposed to a {sup 238}Pu ceramic aerosol gave estimated intakes of 390-8,200 Bq and associated initial pulmonary burdens of 80-1,700 Bq. The resulting 50-y dose commitments to critical organs per Bq of {sup 238}Pu intake were estimated to be 0.5 mSv for the thoracic region, 0.2more » mSv for the liver, and 1 mSv for the bone surfaces. 29 refs., 8 figs., 7 tabs.« less

Authors:
 [1]; ;  [2]
  1. Univ. of Florida, Gainsville, FL (United States)
  2. Inhalation Toxicology Research Institute, Albuquerque, NM (United States); and others
Publication Date:
Sponsoring Org.:
USDOE
OSTI Identifier:
255122
DOE Contract Number:  
AC04-76EV01013
Resource Type:
Journal Article
Journal Name:
Health Physics
Additional Journal Information:
Journal Volume: 68; Journal Issue: 3; Other Information: PBD: Mar 1995
Country of Publication:
United States
Language:
English
Subject:
56 BIOLOGY AND MEDICINE, APPLIED STUDIES; CRITICAL ORGANS; DOSE COMMITMENTS; DOGS; LUNGS; PLUTONIUM DIOXIDE; INHALATION; URINE; RADIOASSAY; BIOLOGICAL RADIATION EFFECTS; BIOASSAY; EXCRETION; INTAKE; PLUTONIUM; RETENTION; SOLUBILITY; MAN; OCCUPATIONAL EXPOSURE; PLUTONIUM 238; PLUTONIUM 239; RADIOACTIVE AEROSOLS

Citation Formats

Hickman, A W, Inhalation Toxicology Research Institute, Albuquerque, NM, Griffith, W C, and Guilmette, R A. Application of a canine {sup 238}Pu biokinetics/dosimetry model to human bioassay data. United States: N. p., 1995. Web. doi:10.1097/00004032-199503000-00008.
Hickman, A W, Inhalation Toxicology Research Institute, Albuquerque, NM, Griffith, W C, & Guilmette, R A. Application of a canine {sup 238}Pu biokinetics/dosimetry model to human bioassay data. United States. https://doi.org/10.1097/00004032-199503000-00008
Hickman, A W, Inhalation Toxicology Research Institute, Albuquerque, NM, Griffith, W C, and Guilmette, R A. 1995. "Application of a canine {sup 238}Pu biokinetics/dosimetry model to human bioassay data". United States. https://doi.org/10.1097/00004032-199503000-00008.
@article{osti_255122,
title = {Application of a canine {sup 238}Pu biokinetics/dosimetry model to human bioassay data},
author = {Hickman, A W and Inhalation Toxicology Research Institute, Albuquerque, NM and Griffith, W C and Guilmette, R A},
abstractNote = {Associated with the use of {sup 238}Pu in thermoelectric power sources for space probes is the potential for human exposure, primarily by inhalation and most likely as {sup 238}PuO{sub 2}. Several models have been developed for assessing the level of intake and predicting the resulting radiation dose following human exposure to {sup 239}Pu. However, there are indications that existing models do not adequately describe the disposition and dosimetry of {sup 239}Pu following human exposure. In this study, a canine model that accounts for these differences has been adapted for use with human excretion data. The model is based on existing knowledge about organ retention of plutonium. An analysis of the sensitivity of the model to changes in aerosol-associated properties indicated that predictions of urinary excretion are most sensitive to changes in particle solubility and diameter and in the ratio of fragment:particle surface area. Application of the model to urinary excretion data from seven workers exposed to a {sup 238}Pu ceramic aerosol gave estimated intakes of 390-8,200 Bq and associated initial pulmonary burdens of 80-1,700 Bq. The resulting 50-y dose commitments to critical organs per Bq of {sup 238}Pu intake were estimated to be 0.5 mSv for the thoracic region, 0.2 mSv for the liver, and 1 mSv for the bone surfaces. 29 refs., 8 figs., 7 tabs.},
doi = {10.1097/00004032-199503000-00008},
url = {https://www.osti.gov/biblio/255122}, journal = {Health Physics},
number = 3,
volume = 68,
place = {United States},
year = {1995},
month = {3}
}