Potential linkage disequilibrium between schizophrenia and locus D22S278 on the long arm of chromosome 22

Journal Article · Mon Oct 09 00:00:00 EDT 1995 · American Journal of Medical Genetics

DOI:https://doi.org/10.1002/ajmg.1320600521· OSTI ID:254395

Moises, H W; Yang, L; Havsteen, B ^[1]

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1. Kiel Univ. (Germany); and others

Locus D22S278 at 22q12 has been implicated in schizophrenia by sib-pair analysis. In order to replicate these results, we performed the transmission test for linkage disequilibrium (TDT) in 113 unrelated schizophrenic patients and their 226 parents. Evidence for potential linkage disequilibrium was obtained between schizophrenia and allele 243 of the marker AFM 182xd12 at the locus D22S278 (P = 0.02). The results of our study suggest a detectable oligogenic gene in a multigene system for schizophrenia closely linked to D22S278 on the long arm of chromosome 22. If confirmed by others, this finding could lead to the identification of a schizophrenia susceptibility gene. 12 refs., 1 tab.

• Sponsoring Organization: USDOE
• OSTI ID: 254395
• Journal Information: American Journal of Medical Genetics, Vol. 60, Issue 5; Other Information: PBD: 9 Oct 1995
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
HUMAN CHROMOSOME 22
GENETIC MAPPING
GENES
MENTAL DISORDERS
GENETICS
ETIOLOGY
RISK ASSESSMENT
PATIENTS
BIOLOGICAL MARKERS
STATISTICS