The structure of the human sterol carrier protein X/sterol carrier protein 2 gene (SCP2)
- Univ. of Pennsylvania School of Medicine, Phildelphia, PA (United States); and others
Sterol carrier protein X (SCPx) is a 58-kDa protein that is localized to peroxisomes. The amino acid sequence of the protein suggests that SCPx may function as a thiolase. The gene encoding SCPx also codes for a 15.3-kDa protein called sterol carrier protein 2 (SCP{sub 2}). Here the authors report the structure of this gene (SCP2), which spans approximately 80 kb and consists of 16 exons and 15 introns. Multiple transcription start sites were identified. The 5{prime} flanking region has characteristics of other peroxisomal protein promoters, which include the absence of a TATA box and G+C-enriched region containing several reverse GC boxes. 24 refs., 3 figs., 1 tab.
- OSTI ID:
- 250268
- Journal Information:
- Genomics, Vol. 24, Issue 2; Other Information: PBD: 15 Nov 1994
- Country of Publication:
- United States
- Language:
- English
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