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Title: Kinetics and dosimetry of thallium-201 in human testes

Abstract

Thallous chloride ({sup 201}Tl) is a well-known imaging agent. It has been shown to accumulate in the testes. In view of this, the testicular kinetics of {sup 201}Tl is investigated in humans and the absorbed dose to the organ calculated. Thallous chloride {sup 201}Tl was injected intravenously into four patients for myocardial perfusion studies. After clinical evaluation, the testicular uptake and clearance of {sup 201}Tl were monitored for about 1 wk using a gamma camera. Testicular uptake of {sup 201}Tl was rapid with a mean biological uptake half-time of 0.67 hr and mean biological clearance half-time of 280 hr. The mean maximum testicular uptake of {sup 201}Tl was about 0.4% of the injected activity. These data were utilized to calculate the average absorbed dose to the testes. The absorbed dose to the testes was calculated to be 3.5 x 10{sup {minus}4} Gy/MBq (1.3 rad/mCi) of injected activity. When the relative biological effectiveness of the Auger emitter {sup 201}Tl is taken into account, the equivalent dose to the testes is 9.5 x 10{sup {minus}4} Sv/MBq (3.5 rem/mCi). 14 refs., 1 fig., 2 tabs.

Authors:
; ;  [1]
  1. New Jersey Medical School, Newark, NJ (United States)|[Univ. of Oxford (United Kingdom)|[Churchill Hospital (United Kingdom) [and others
Publication Date:
OSTI Identifier:
250011
Resource Type:
Journal Article
Journal Name:
Journal of Nuclear Medicine
Additional Journal Information:
Journal Volume: 36; Journal Issue: 4; Other Information: PBD: Apr 1995
Country of Publication:
United States
Language:
English
Subject:
56 BIOLOGY AND MEDICINE, APPLIED STUDIES; TESTES; DOSIMETRY; THALLIUM 201; UPTAKE; CLEARANCE; THALLIUM CHLORIDES

Citation Formats

Rao, D.V., Shepstone, B.J., and Wilkins, H.B.. Kinetics and dosimetry of thallium-201 in human testes. United States: N. p., 1995. Web.
Rao, D.V., Shepstone, B.J., & Wilkins, H.B.. Kinetics and dosimetry of thallium-201 in human testes. United States.
Rao, D.V., Shepstone, B.J., and Wilkins, H.B.. Sat . "Kinetics and dosimetry of thallium-201 in human testes". United States.
@article{osti_250011,
title = {Kinetics and dosimetry of thallium-201 in human testes},
author = {Rao, D.V. and Shepstone, B.J. and Wilkins, H.B.},
abstractNote = {Thallous chloride ({sup 201}Tl) is a well-known imaging agent. It has been shown to accumulate in the testes. In view of this, the testicular kinetics of {sup 201}Tl is investigated in humans and the absorbed dose to the organ calculated. Thallous chloride {sup 201}Tl was injected intravenously into four patients for myocardial perfusion studies. After clinical evaluation, the testicular uptake and clearance of {sup 201}Tl were monitored for about 1 wk using a gamma camera. Testicular uptake of {sup 201}Tl was rapid with a mean biological uptake half-time of 0.67 hr and mean biological clearance half-time of 280 hr. The mean maximum testicular uptake of {sup 201}Tl was about 0.4% of the injected activity. These data were utilized to calculate the average absorbed dose to the testes. The absorbed dose to the testes was calculated to be 3.5 x 10{sup {minus}4} Gy/MBq (1.3 rad/mCi) of injected activity. When the relative biological effectiveness of the Auger emitter {sup 201}Tl is taken into account, the equivalent dose to the testes is 9.5 x 10{sup {minus}4} Sv/MBq (3.5 rem/mCi). 14 refs., 1 fig., 2 tabs.},
doi = {},
journal = {Journal of Nuclear Medicine},
number = 4,
volume = 36,
place = {United States},
year = {1995},
month = {4}
}