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Simulating toxicokinetic variability to identify susceptible and highly exposed populations

Journal Article · · Journal of Exposure Science & Environmental Epidemiology

Not provided.

Research Organization:
Oak Ridge Institute for Science and Education (ORISE), Oak Ridge, TN (United States)
Sponsoring Organization:
USDOE Office of Science (SC)
DOE Contract Number:
SC0014664
OSTI ID:
2425801
Journal Information:
Journal of Exposure Science & Environmental Epidemiology, Journal Name: Journal of Exposure Science & Environmental Epidemiology Journal Issue: 6 Vol. 32; ISSN 1559-0631
Publisher:
Springer Nature
Country of Publication:
United States
Language:
English

References (33)

The Toxicity Data Landscape for Environmental Chemicals journal May 2009
High-throughput in-silico prediction of ionization equilibria for pharmacokinetic modeling journal February 2018
Removal of race from estimation of kidney function journal January 2022
Utility of In Vitro Bioactivity as a Lower Bound Estimate of In Vivo Adverse Effect Levels and in Risk-Based Prioritization journal September 2019
OPERA models for predicting physicochemical properties and environmental fate endpoints journal March 2018
Race, Genetic Ancestry, and Estimating Kidney Function in CKD journal November 2021
A Model Template Approach for Rapid Evaluation and Application of Physiologically Based Pharmacokinetic Models for Use in Human Health Risk Assessments: A Case Study on Per- and Polyfluoroalkyl Substances journal June 2021
Screening of chemicals for human bioaccumulative potential with a physiologically based toxicokinetic model journal November 2011
The ToxCast Program for Prioritizing Toxicity Testing of Environmental Chemicals journal September 2006
New approach methodologies for exposure science journal June 2019
httk : R Package for High-Throughput Toxicokinetics journal January 2017
A standard nomenclature for structures of the kidney journal January 1988
Confronting Environmental Racism journal May 2021
Incorporating High-Throughput Exposure Predictions With Dosimetry-Adjusted In Vitro Bioactivity to Inform Chemical Toxicity Testing journal August 2015
PBTK modelling platforms and parameter estimation tools to enable animal-free risk assessment journal February 2014
The exposure data landscape for manufactured chemicals journal January 2012
Accelerating the Pace of Chemical Risk Assessment journal March 2018
Toxicokinetics as a key to the integrated toxicity risk assessment based primarily on non-animal approaches journal August 2013
A Unifying Approach for GFR Estimation: Recommendations of the NKF-ASN Task Force on Reassessing the Inclusion of Race in Diagnosing Kidney Disease journal February 2022
A New Equation to Estimate Glomerular Filtration Rate journal May 2009
Open-source QSAR models for pKa prediction using multiple machine learning approaches journal September 2019
National Estimates of CKD Prevalence and Potential Impact of Estimating Glomerular Filtration Rate Without Race journal June 2021
Kidney Disease, Race, and GFR Estimation journal May 2020
High-throughput PBTK models for in vitro to in vivo extrapolation journal June 2021
Identifying populations sensitive to environmental chemicals by simulating toxicokinetic variability journal September 2017
Evaluating In Vitro-In Vivo Extrapolation of Toxicokinetics journal January 2018
Reconsidering the Consequences of Using Race to Estimate Kidney Function journal July 2019
Exploring sex differences in human health risk assessment for PFNA and PFDA using a PBPK model journal November 2018
Transforming Environmental Health Protection journal February 2008
Prediction of the Clearance of Eleven Drugs and Associated Variability in Neonates, Infants and Children journal January 2006
Assessing Toxicokinetic Uncertainty and Variability in Risk Prioritization journal September 2019
Time to Eliminate Health Care Disparities in the Estimation of Kidney Function journal November 2021
Reassessing the Inclusion of Race in Diagnosing Kidney Diseases: An Interim Report From the NKF-ASN Task Force journal July 2021

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