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A G Protein-Biased Ligand at the μ -Opioid Receptor Is Potently Analgesic with Reduced Gastrointestinal and Respiratory Dysfunction Compared with Morphine
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January 2013 |
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Toward Directing Opioid Receptor Signaling to Refine Opioid Therapeutics
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January 2020 |
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Two protonation switches control rhodopsin activation in membranes
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November 2008 |
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Features and development of Coot
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March 2010 |
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Structure of the µ-opioid receptor–Gi protein complex
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June 2018 |
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PHENIX: a comprehensive Python-based system for macromolecular structure solution
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January 2010 |
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μ-Opioid receptor desensitization by β-arrestin-2 determines morphine tolerance but not dependence
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December 2000 |
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G-protein antisense oligodeoxyribonucleotides and μ-opioid supraspinal antinociception
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June 1994 |
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An Opioid Agonist that Does Not Induce μ-Opioid Receptor—Arrestin Interactions or Receptor Internalization
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November 2006 |
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Pharmacological and genetic manipulations at the µ-opioid receptor reveal arrestin-3 engagement limits analgesic tolerance and does not exacerbate respiratory depression in mice
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July 2021 |
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Bias Factor and Therapeutic Window Correlate to Predict Safer Opioid Analgesics
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November 2017 |
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Oxidative Metabolism as a Modulator of Kratom’s Biological Actions
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November 2021 |
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cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination
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February 2017 |
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Conformational Basis of G Protein-Coupled Receptor Signaling Versatility
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September 2020 |
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PTRAJ and CPPTRAJ: Software for Processing and Analysis of Molecular Dynamics Trajectory Data
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June 2013 |
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[19] Integrated methods for the construction of three-dimensional models and computational probing of structure-function relations in G protein-coupled receptors
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January 1995 |
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Mu-Opioid Receptor Coupling to Gαo Plays an Important Role in Opioid Antinociception
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June 2011 |
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A Simple Method for Quantifying Functional Selectivity and Agonist Bias
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January 2012 |
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Crystal structure of the µ-opioid receptor bound to a morphinan antagonist
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March 2012 |
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Predicted Mode of Binding to and Allosteric Modulation of the μ-Opioid Receptor by Kratom’s Alkaloids with Reported Antinociception In Vivo
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December 2020 |
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Kinetics and Mechanism of Fentanyl Dissociation from the μ-Opioid Receptor
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November 2021 |
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CHARMM general force field: A force field for drug-like molecules compatible with the CHARMM all-atom additive biological force fields
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January 2009 |
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Structure-based discovery of opioid analgesics with reduced side effects
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August 2016 |
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GemSpot: A Pipeline for Robust Modeling of Ligands into Cryo-EM Maps
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June 2020 |
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A Novel Mitragynine Analog with Low-Efficacy Mu Opioid Receptor Agonism Displays Antinociception with Attenuated Adverse Effects
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September 2021 |
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Deletion of guanine nucleotide binding protein αz subunit in mice induces a gene dose dependent tolerance to morphine
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May 2004 |
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The Effect of pH on β2 Adrenoceptor Function
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February 2000 |
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Metabolism of a Kratom Alkaloid Metabolite in Human Plasma Increases Its Opioid Potency and Efficacy
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July 2020 |
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Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site
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February 2021 |
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On the Role of the Crystal Environment in Determining Protein Side-chain Conformations
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July 2002 |
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Numerical integration of the cartesian equations of motion of a system with constraints: molecular dynamics of n-alkanes
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March 1977 |
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The history and development of the fentanyl series
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April 1992 |
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Extra Precision Glide: Docking and Scoring Incorporating a Model of Hydrophobic Enclosure for Protein−Ligand Complexes
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October 2006 |
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New tools for automated high-resolution cryo-EM structure determination in RELION-3
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November 2018 |
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VMD: Visual molecular dynamics
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February 1996 |
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7-Hydroxymitragynine Is an Active Metabolite of Mitragynine and a Key Mediator of Its Analgesic Effects
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May 2019 |
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Biased Opioid Ligands
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September 2020 |
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Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists
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March 2020 |
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UCSF ChimeraX: Meeting modern challenges in visualization and analysis: UCSF ChimeraX Visualization System
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September 2017 |
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Distinct profiles of functional discrimination among G proteins determine the actions of G protein–coupled receptors
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December 2015 |
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UCSF Chimera?A visualization system for exploratory research and analysis
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January 2004 |
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Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2
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September 2016 |
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Structural insights into µ-opioid receptor activation
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August 2015 |
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Gctf: Real-time CTF determination and correction
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January 2016 |
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ß-arrestin 2 germline knockout does not attenuate opioid respiratory depression
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May 2021 |
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A Biased View ofμ-Opioid Receptors?
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June 2019 |
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TRUPATH, an open-source biosensor platform for interrogating the GPCR transducerome
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May 2020 |
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Molecular mechanism of biased signaling in a prototypical G protein–coupled receptor
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February 2020 |
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GPU-Accelerated Molecular Dynamics and Free Energy Methods in Amber18: Performance Enhancements and New Features
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September 2018 |
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MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy
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February 2017 |
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Ensemble-Based Convergence Analysis of Biomolecular Trajectories
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July 2006 |
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Phosphorylation-deficient G-protein-biased μ-opioid receptors improve analgesia and diminish tolerance but worsen opioid side effects
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January 2019 |