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Preclinical development of ZED8, an 89Zr immuno-PET reagent for monitoring tumor CD8 status in patients undergoing cancer immunotherapy

Journal Article · · European Journal of Nuclear Medicine and Molecular Imaging
Not provided.
Research Organization:
SLAC National Accelerator Laboratory, Menlo Park, CA (United States). Stanford Synchrotron Radiation Lightsource (SSRL)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC02-76SF00515
OSTI ID:
2423921
Journal Information:
European Journal of Nuclear Medicine and Molecular Imaging, Journal Name: European Journal of Nuclear Medicine and Molecular Imaging Journal Issue: 2 Vol. 50; ISSN 1619-7070
Publisher:
Springer Nature
Country of Publication:
United States
Language:
English

References (54)

Anti-CD8 Antibodies Can Trigger CD8+ T Cell Effector Function in the Absence of TCR Engagement and Improve Peptide–MHCI Tetramer Staining journal July 2011
Imaging Reveals Importance of Shape and Flexibility for Glomerular Filtration of Biologics journal July 2021
Pharmacokinetics and Biodistribution of a [89Zr]Zr-DFO-MSTP2109A Anti-STEAP1 Antibody in Metastatic Castration-Resistant Prostate Cancer Patients journal May 2019
The Production, Quality Control, and Characterization of ZED8, a CD8-Specific 89Zr-Labeled Immuno-PET Clinical Imaging Agent journal January 2020
In vivo biodistribution and accumulation of 89Zr in mice journal July 2011
Ultrafast Preconditioned Conjugate Gradient OSEM algorithm for fully 3D PET reconstruction conference October 2010
89Zr-atezolizumab imaging as a non-invasive approach to assess clinical response to PD-L1 blockade in cancer journal November 2018
A review of background findings in cynomolgus monkeys (Macaca fascicularis) from three different geographical origins journal November 2006
PD-1 blockade induces responses by inhibiting adaptive immune resistance journal November 2014
Tumour-infiltrating CD8+ lymphocytes as an independent predictive factor for pathological complete response to primary systemic therapy in breast cancer journal October 2013
Imaging Patients with Metastatic Castration-Resistant Prostate Cancer Using89Zr-DFO-MSTP2109A Anti-STEAP1 Antibody journal May 2019
The calm after the cytokine storm: lessons from the TGN1412 trial journal April 2008
Factors determining antibody distribution in tumors journal January 2008
Tumor infiltrating lymphocytes in ovarian cancer journal April 2015
Role of MetMAb (OA-5D5) in c-MET active lung malignancies journal October 2011
[89Zr]Trastuzumab: Evaluation of Radiation Dosimetry, Safety, and Optimal Imaging Parameters in Women with HER2-Positive Breast Cancer journal May 2016
CD8-targeted PET Imaging of Tumor Infiltrating T cells in Patients with Cancer: A Phase I First-in-Human Study of 89Zr-Df-IAB22M2C, a Radiolabeled anti-CD8 Minibody journal August 2021
Phase I Dose-Escalation Study of Onartuzumab as a Single Agent and in Combination with Bevacizumab in Patients with Advanced Solid Malignancies journal March 2014
CD8 + cytotoxic T lymphocytes in cancer immunotherapy: A review journal November 2018
Comparison of the octadentate bifunctional chelator DFO*-pPhe-NCS and the clinically used hexadentate bifunctional chelator DFO-pPhe-NCS for 89Zr-immuno-PET journal August 2016
Immuno-PET identifies the myeloid compartment as a key contributor to the outcome of the antitumor response under PD-1 blockade journal August 2019
Molecular imaging as a tool to investigate heterogeneity of advanced HER2-positive breast cancer and to predict patient outcome under trastuzumab emtansine (T-DM1): the ZEPHIR trial journal November 2015
Bispecific antibodies with natural architecture produced by co-culture of bacteria expressing two distinct half-antibodies journal July 2013
Resolution and noise properties of MAP reconstruction for fully 3-D PET journal May 2000
Ultrasonography of the normal kidney in the cynomolgus monkey (Macaca fascicularis): morphologic and Doppler findings journal April 2000
First-in-Humans Imaging with 89Zr-Df-IAB22M2C Anti-CD8 Minibody in Patients with Solid Malignancies: Preliminary Pharmacokinetics, Biodistribution, and Lesion Targeting journal October 2019
Is Needle Biopsy Clinically Useful in Preoperative Grading of Central Chondrosarcoma of the Pelvis and Long Bones? journal March 2017
Optimization of 89Zr PET Imaging for Improved Multisite Quantification and Lesion Detection Using an Anthropomorphic Phantom journal October 2019
Automated Selection of DAB-labeled Tissue for Immunohistochemical Quantification journal May 2003
Projecting human pharmacokinetics of therapeutic antibodies from nonclinical data: What have we learned? journal January 2011
89Zr-Bevacizumab PET Imaging in Primary Breast Cancer journal May 2013
PET/CT-Derived Whole-Body and Bone Marrow Dosimetry of 89Zr-Cetuximab journal January 2015
Development and Validation of a PET/SPECT Radiopharmaceutical in Oncology journal September 2021
Molecular Interaction Characterization Strategies for the Development of New Biotherapeutic Antibody Modalities journal March 2020
RAS status and neoadjuvant chemotherapy impact CD8+ cells and tumor HLA class I expression in liver metastatic colorectal cancer journal November 2018
Structural Basis of the CD8αβ/MHC Class I Interaction: Focused Recognition Orients CD8β to a T Cell Proximal Position journal July 2009
An octadentate bifunctional chelating agent for the development of stable zirconium-89 based molecular imaging probes journal January 2014
Identification of proteomic biomarkers predicting prostate cancer aggressiveness and lethality despite biopsy-sampling error journal July 2014
Onartuzumab (MetMAb): Using Nonclinical Pharmacokinetic and Concentration–Effect Data to Support Clinical Development journal July 2013
Abstract LB037: 89ZED88082A PET imaging to visualize CD8+ T cells in patients with cancer treated with immune checkpoint inhibitor journal July 2021
Oncolytic Virotherapy Promotes Intratumoral T Cell Infiltration and Improves Anti-PD-1 Immunotherapy journal September 2017
Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing journal March 2012
Novel human IgG1 and IgG4 Fc-engineered antibodies with completely abolished immune effector functions journal August 2016
First Human Imaging Studies with the EXPLORER Total-Body PET Scanner* journal February 2019
Monovalent antibody design and mechanism of action of onartuzumab, a MET antagonist with anti-tumor activity as a therapeutic agent journal July 2013
Can PD-L1 expression evaluated by biopsy sample accurately reflect its expression in the whole tumour in gastric cancer? journal July 2019
Total-Body PET and Highly Stable Chelators Together Enable Meaningful 89 Zr-Antibody PET Studies up to 30 Days After Injection journal September 2019
CD103+ Tumor-Resident CD8+ T Cells Are Associated with Improved Survival in Immunotherapy-Naïve Melanoma Patients and Expand Significantly During Anti–PD-1 Treatment journal July 2018
Immuno-PET of the Hepatocyte Growth Factor Receptor Met Using the 1-Armed Antibody Onartuzumab journal August 2012
Immuno-PET: A Navigator in Monoclonal Antibody Development and Applications journal December 2007
‘Knobs-into-holes’ engineering of antibody C H 3 domains for heavy chain heterodimerization journal January 1996
Head-to-head comparison of DFO* and DFO chelators: selection of the best candidate for clinical 89Zr-immuno-PET journal September 2020
Development of an 18F-labeled anti-human CD8 VHH for same-day immunoPET imaging journal November 2022
Immune infiltration in human tumors: a prognostic factor that should not be ignored journal November 2009

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