Systematic Design of Adenosine Analogs as Inhibitors of a Clostridioides difficile- Specific DNA Adenine Methyltransferase Required for Normal Sporulation and Persistence

Zhou, Jujun; Horton, John R.; Menna, Martina; Fiorentino, Francesco; Ren, Ren; Yu, Dan; Hajian, Taraneh; Vedadi, Masoud; Mazzoccanti, Giulia; Ciogli, Alessia; Weinhold, Elmar; Hüben, Michael; Blumenthal, Robert M.; Zhang, Xing; Mai, Antonello; Rotili, Dante; Cheng, Xiaodong

doi:10.1021/acs.jmedchem.2c01789

Systematic Design of Adenosine Analogs as Inhibitors of a Clostridioides difficile- Specific DNA Adenine Methyltransferase Required for Normal Sporulation and Persistence

Journal Article · 29 December 2022 · Journal of Medicinal Chemistry

DOI:https://doi.org/10.1021/acs.jmedchem.2c01789· OSTI ID:2423684

Zhou, Jujun ^[1]; Horton, John R. ^[1]; Menna, Martina ^[2]; ^[2]; Ren, Ren ^[1]; Yu, Dan ^[1]; Hajian, Taraneh ^[3]; ^[4]; Mazzoccanti, Giulia ^[2]; ^[2]; Weinhold, Elmar ^[5]; Hüben, Michael ^[5]; Blumenthal, Robert M. ^[6]; Zhang, Xing ^[1]; ^[7]; ^[2]; ^[1]

Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, United States
Department of Drug Chemistry and Technologies, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy
Structural Genomics Consortium, University of Toronto, Toronto, ON M5S 1A8, Canada
Structural Genomics Consortium, University of Toronto, Toronto, ON M5S 1A8, Canada; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON M5S 1A8, Canada
Institute of Organic Chemistry, RWTH Aachen University, D-52056 Aachen, Germany
Department of Medical Microbiology and Immunology, and Program in Bioinformatics, The University of Toledo College of Medicine and Life Sciences, Toledo, Ohio 43614, United States
Department of Drug Chemistry and Technologies, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy; Pasteur Institute, Cenci-Bolognetti Foundation, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy

Not provided.

Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC02-06CH11357

OSTI ID:: 2423684

Journal Information:: Journal of Medicinal Chemistry, Journal Name: Journal of Medicinal Chemistry Journal Issue: 1 Vol. 66; ISSN 0022-2623

Publisher:: American Chemical Society (ACS)

Country of Publication:: United States

Language:: English

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