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Structures and mechanisms of tRNA methylation by METTL1–WDR4

Journal Article · · Nature (London)
Not provided.
Research Organization:
Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC02-06CH11357
OSTI ID:
2423667
Journal Information:
Nature (London), Journal Name: Nature (London) Journal Issue: 7943 Vol. 613; ISSN 0028-0836
Publisher:
Nature Publishing Group
Country of Publication:
United States
Language:
English

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METTL1‐m7G‐EGFR/EFEMP1 axis promotes the bladder cancer development journal December 2021
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METTL1 promotes hepatocarcinogenesis via m7G tRNA modification‐dependent translation control journal December 2021
METTL1/WDR4-mediated m7G tRNA modifications and m7G codon usage promote mRNA translation and lung cancer progression journal December 2021
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METTL1-mediated m7G methylation maintains pluripotency in human stem cells and limits mesoderm differentiation and vascular development journal July 2020
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HIV-1 matrix-tRNA complex structure reveals basis for host control of Gag localization journal September 2021
Structural model of the M7G46 Methyltransferase TrmB in complex with tRNA journal May 2021
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METTL1-mediated m7G modification of Arg-TCT tRNA drives oncogenic transformation journal August 2021
Two proteins that form a complex are required for 7-methylguanosine modification of yeast tRNA journal October 2002
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tRNA elbow modifications affect the tRNA pseudouridine synthase TruB and the methyltransferase TrmA journal May 2020
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Mutation in WDR4 impairs tRNA m7G46 methylation and causes a distinct form of microcephalic primordial dwarfism journal September 2015
Monomeric tRNA (m7G46) methyltransferase from Escherichia coli presents a novel structure at the function‐essential insertion journal April 2009
tRNA m7G methyltransferase Trm8p/Trm82p: Evidence linking activity to a growth phenotype and implicating Trm82p in maintaining levels of active Trm8p journal April 2005
RNA recognition mechanism of eukaryote tRNA (m7G46) methyltransferase (Trm8–Trm82 complex) journal March 2007
N7-methylguanosine tRNA modification promotes esophageal squamous cell carcinoma tumorigenesis via the RPTOR/ULK1/autophagy axis journal March 2022
Emerging roles of tRNA in adaptive translation, signalling dynamics and disease journal December 2014
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The epitranscriptome beyond m6A journal November 2020
RNA modifications modulate gene expression during development journal September 2018
tRNA Modifications: Impact on Structure and Thermal Adaptation journal April 2017
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A novel cause for primordial dwarfism revealed: defective tRNA modification journal October 2015
Reversible RNA phosphorylation stabilizes tRNA for cellular thermotolerance journal April 2022
Modifications and functional genomics of human transfer RNA journal February 2018
N7-Methylguanosine tRNA modification enhances oncogenic mRNA translation and promotes intrahepatic cholangiocarcinoma progression journal August 2021
The crystal structure of HIV reverse-transcription primer tRNA(Lys,3) shows a canonical anticodon loop journal October 2000
Positive-unlabeled convolutional neural networks for particle picking in cryo-electron micrographs journal October 2019
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The tRNA methylase METTL1 is phosphorylated and inactivated by PKB and RSK in vitro and in cells journal April 2005
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N7-methylguanosine tRNA modification promotes tumorigenesis and chemoresistance through WNT/β-catenin pathway in nasopharyngeal carcinoma journal February 2022
Rapid tRNA Decay Can Result from Lack of Nonessential Modifications journal January 2006
Overexpressed methyltransferase-like 1 (METTL1) increased chemosensitivity of colon cancer cells to cisplatin by regulating miR-149-3p/S100A4/p53 axis journal December 2019
Crystal Structure of the Human tRNA m1A58 Methyltransferase–tRNA3Lys Complex: Refolding of Substrate tRNA Allows Access to the Methylation Target journal December 2015
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Methyltransferase‑like 1 regulates lung adenocarcinoma A549 cell proliferation and autophagy via the AKT/mTORC1 signaling pathway journal February 2021
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METTL1 overexpression is correlated with poor prognosis and promotes hepatocellular carcinoma via PTEN journal August 2019
Speech and language delay in a patient with WDR4 mutations journal August 2018
tRNA Modifying Enzymes, NSUN2 and METTL1, Determine Sensitivity to 5-Fluorouracil in HeLa Cells journal September 2014
The RNA modification landscape in human disease journal August 2017

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