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The ubiquinone synthesis pathway is a promising drug target for Chagas disease
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journal
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February 2021 |
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ADCK3/COQ8A: the choice target of the UbiB protein kinase-like family
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journal
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September 2019 |
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Features and development of Coot
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journal
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March 2010 |
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A Defect in Coenzyme Q Biosynthesis Is Responsible for the Respiratory Deficiency in Saccharomyces cerevisiae abc1 Mutants
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journal
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March 2001 |
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Data processing and analysis with the autoPROC toolbox
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journal
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March 2011 |
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Phaser crystallographic software
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journal
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July 2007 |
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A Novel Triphenylphosphonium Carrier to Target Mitochondria without Uncoupling Oxidative Phosphorylation
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journal
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January 2021 |
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2-Propylphenol Allosterically Modulates COQ8A to Enhance ATPase Activity
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journal
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July 2022 |
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Design of a Cyclin G Associated Kinase (GAK)/Epidermal Growth Factor Receptor (EGFR) Inhibitor Set to Interrogate the Relationship of EGFR and GAK in Chordoma
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journal
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April 2019 |
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Delivery of bioactive molecules to mitochondria in vivo
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journal
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April 2003 |
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Trends in kinase drug discovery: targets, indications and inhibitor design
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journal
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August 2021 |
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Novel Families of Putative Protein Kinases in Bacteria and Archaea: Evolution of the “Eukaryotic” Protein Kinase Superfamily
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journal
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October 1998 |
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ADCK3, an Ancestral Kinase, Is Mutated in a Form of Recessive Ataxia Associated with Coenzyme Q10 Deficiency
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journal
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March 2008 |
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SGC-GAK-1: A Chemical Probe for Cyclin G Associated Kinase (GAK)
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journal
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February 2019 |
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Conserved Lipid and Small-Molecule Modulation of COQ8 Reveals Regulation of the Ancient Kinase-like UbiB Family
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journal
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February 2018 |
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Target engagement and drug residence time can be observed in living cells with BRET
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journal
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December 2015 |
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Clinico‐Genetic, Imaging and Molecular Delineation of COQ8A‐Ataxia: A Multicenter Study of 59 Patients
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journal
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June 2020 |
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Targeting an EGFR Water Network with 4‐Anilinoquin(az)oline Inhibitors for Chordoma
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journal
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September 2019 |
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XDS
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journal
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January 2010 |
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LigPlot+: Multiple Ligand–Protein Interaction Diagrams for Drug Discovery
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journal
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October 2011 |
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Chemical Probes for Understudied Kinases: Challenges and Opportunities
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journal
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September 2021 |
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A Mitochondrial Protein Compendium Elucidates Complex I Disease Biology
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journal
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July 2008 |
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Mitochondrial ADCK3 Employs an Atypical Protein Kinase-like Fold to Enable Coenzyme Q Biosynthesis
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journal
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January 2015 |
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Identification of 4‐Anilinoquin(az)oline as a Cell‐Active Protein Kinase Novel 3 (PKN3) Inhibitor Chemotype**
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journal
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May 2022 |
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Cerebellar Ataxia and Coenzyme Q Deficiency through Loss of Unorthodox Kinase Activity
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journal
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August 2016 |
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Design and Analysis of the 4‐Anilinoquin(az)oline Kinase Inhibition Profiles of GAK/SLK/STK10 Using Quantitative Structure‐Activity Relationships
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journal
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November 2019 |
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Kinase drug discovery 20 years after imatinib: progress and future directions
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journal
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May 2021 |
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The synthesis and functional evaluation of a mitochondria-targeted hydrogen sulfide donor, (10-oxo-10-(4-(3-thioxo-3H-1,2-dithiol-5-yl)phenoxy)decyl)triphenylphosphonium bromide (AP39)
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journal
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January 2014 |
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Dynamic Reprogramming of the Kinome in Response to Targeted MEK Inhibition in Triple-Negative Breast Cancer
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journal
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April 2012 |
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Regulation of hepatic coenzyme Q biosynthesis by dietary omega-3 polyunsaturated fatty acids
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journal
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October 2021 |
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Selective Targeting of a Redox-active Ubiquinone to Mitochondria within Cells
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journal
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February 2001 |
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The Evolution of Protein Kinase Inhibitors from Antagonists to Agonists of Cellular Signaling
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journal
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July 2011 |
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Utilizing comprehensive and mini-kinome panels to optimize the selectivity of quinoline inhibitors for cyclin G associated kinase (GAK)
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journal
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July 2019 |
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Identification of Escherichia coli ubiB, a Gene Required for the First Monooxygenase Step in Ubiquinone Biosynthesis
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journal
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September 2000 |
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Lipophilic Triphenylphosphonium Cations Inhibit Mitochondrial Electron Transport Chain and Induce Mitochondrial Proton Leak
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journal
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April 2015 |
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Biochemistry of Mitochondrial Coenzyme Q Biosynthesis
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journal
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October 2017 |
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ADCK4 mutations promote steroid-resistant nephrotic syndrome through CoQ10 biosynthesis disruption
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journal
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November 2013 |
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Challenges and Opportunities in Cancer Drug Resistance
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journal
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July 2020 |
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JBluIce–EPICS control system for macromolecular crystallography
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journal
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February 2011 |
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Evolutionary conservation of the clk-1-dependent mechanism of longevity: loss of mclk1 increases cellular fitness and lifespan in mice
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journal
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October 2005 |
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Mutations in COQ8B (ADCK4) found in patients with steroid-resistant nephrotic syndrome alter COQ8B function
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journal
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December 2017 |
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Towards automated crystallographic structure refinement with phenix.refine
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journal
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March 2012 |
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Unexplored therapeutic opportunities in the human genome
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journal
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March 2018 |
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The Anti-neurodegeneration Drug Clioquinol Inhibits the Aging-associated Protein CLK-1
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journal
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January 2009 |
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FSP1 is a glutathione-independent ferroptosis suppressor
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journal
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October 2019 |
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4-Nitrobenzoate inhibits coenzyme Q biosynthesis in mammalian cell cultures
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journal
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June 2010 |
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UbiB proteins regulate cellular CoQ distribution in Saccharomyces cerevisiae
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journal
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August 2021 |
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ABC1K atypical kinases in plants: filling the organellar kinase void
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journal
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September 2012 |
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Mitochondria-Targeted Triphenylphosphonium-Based Compounds: Syntheses, Mechanisms of Action, and Therapeutic and Diagnostic Applications
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journal
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June 2017 |
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The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis
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journal
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October 2019 |
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Defining mitochondrial protein functions through deep multiomic profiling
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journal
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May 2022 |
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Extension of Life-Span in Caenorhabditis elegans by a Diet Lacking Coenzyme Q
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journal
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January 2002 |
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electronic Ligand Builder and Optimization Workbench ( eLBOW ): a tool for ligand coordinate and restraint generation
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journal
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September 2009 |
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The Protein Kinase Complement of the Human Genome
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journal
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December 2002 |
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Mitochondrially targeted compounds and their impact on cellular bioenergetics
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journal
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January 2013 |
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Quantitative, Wide-Spectrum Kinase Profiling in Live Cells for Assessing the Effect of Cellular ATP on Target Engagement
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journal
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February 2018 |
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The Kinase Chemogenomic Set (KCGS): An Open Science Resource for Kinase Vulnerability Identification
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journal
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January 2021 |
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Identification of small molecule inhibitors of human COQ7
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journal
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January 2020 |
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Identification and Optimization of 4‐Anilinoquinolines as Inhibitors of Cyclin G Associated Kinase
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journal
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November 2017 |