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Shorter Is Better: The α-( l )-Threofuranosyl Nucleic Acid Modification Improves Stability, Potency, Safety, and Ago2 Binding and Mitigates Off-Target Effects of Small Interfering RNAs

Journal Article · · Journal of the American Chemical Society
DOI:https://doi.org/10.1021/jacs.3c04744· OSTI ID:2423608
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  1. Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, Massachusetts 02142, United States
  2. Department of Pharmaceutical Sciences, University of California, Irvine, California 92697-3958, United States
  3. Department of Biochemistry, School of Medicine, Vanderbilt University, Nashville, Tennessee 37232-0146, United States
+ Show Author Affiliations
Not provided.
Research Organization:
Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC02-06CH11357
OSTI ID:
2423608
Journal Information:
Journal of the American Chemical Society, Journal Name: Journal of the American Chemical Society Journal Issue: 36 Vol. 145; ISSN 0002-7863
Publisher:
American Chemical Society (ACS)
Country of Publication:
United States
Language:
English

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  • Wilds, Christopher J.; Wawrzak, Zdzislaw; Krishnamurthy, Ramanarayanan
  • Journal of the American Chemical Society, Vol. 124, Issue 46 https://doi.org/10.1021/ja0207807
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