Mechanism of Allosteric Modulation of Nicotinamide Phosphoribosyltransferase to Elevate Cellular NAD +

Ratia, Kiira M.; Shen, Zhengnan; Gordon-Blake, Jesse; Lee, Hyun; Laham, Megan S.; Krider, Isabella S.; Christie, Nicholas; Ackerman-Berrier, Martha; Penton, Christopher; Knowles, Natalie G.; Musku, Soumya Reddy; Fu, Jiqiang; Velma, Ganga Reddy; Xiong, Rui; Thatcher, Gregory R.  J.

doi:10.1021/acs.biochem.2c00655

Mechanism of Allosteric Modulation of Nicotinamide Phosphoribosyltransferase to Elevate Cellular NAD ⁺

Journal Article · 05 February 2023 · Biochemistry

DOI:https://doi.org/10.1021/acs.biochem.2c00655· OSTI ID:2423509

Ratia, Kiira M. ^[1]; Shen, Zhengnan ^[2]; ^[3]; ^[1]; Laham, Megan S. ^[4]; Krider, Isabella S. ^[4]; Christie, Nicholas ^[4]; Ackerman-Berrier, Martha ^[2]; Penton, Christopher ^[2]; Knowles, Natalie G. ^[2]; Musku, Soumya Reddy ^[2]; Fu, Jiqiang ^[2]; Velma, Ganga Reddy ^[2]; Xiong, Rui ^[2]; Thatcher, Gregory R. J. ^[5]

Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago (UIC), Chicago, Illinois 60612, United States; Research Resources Center, University of Illinois at Chicago (UIC), Chicago, Illinois 60612, United States
Department of Pharmacology & Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona 85721, United States
Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago (UIC), Chicago, Illinois 60612, United States
Department of Chemistry & Biochemistry, Colleges of Science and Medicine, University of Arizona, Tucson, Arizona 85721, United States
Department of Pharmacology & Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona 85721, United States; Department of Chemistry & Biochemistry, Colleges of Science and Medicine, University of Arizona, Tucson, Arizona 85721, United States

Not provided.

Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC02-06CH11357

OSTI ID:: 2423509

Journal Information:: Biochemistry, Journal Name: Biochemistry Journal Issue: 4 Vol. 62; ISSN 0006-2960

Publisher:: American Chemical Society (ACS)

Country of Publication:: United States

Language:: English

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