Discovery and Characterization of a Chemical Probe Targeting the Zinc-Finger Ubiquitin-Binding Domain of HDAC6

Harding, Rachel J.; Franzoni, Ivan; Mann, Mandeep K.; Szewczyk, Magdalena M.; Mirabi, Bijan; Ferreira de Freitas, Renato; Owens, Dominic D.  G.; Ackloo, Suzanne; Scheremetjew, Alexej; Juarez-Ornelas, Kevin A.; Sanichar, Randy; Baker, Rachel J.; Dank, Christian; Brown, Peter J.; Barsyte-Lovejoy, Dalia; Santhakumar, Vijayaratnam; Schapira, Matthieu; Lautens, Mark; Arrowsmith, Cheryl H.

doi:10.1021/acs.jmedchem.3c00314

Discovery and Characterization of a Chemical Probe Targeting the Zinc-Finger Ubiquitin-Binding Domain of HDAC6

Journal Article · 27 July 2023 · Journal of Medicinal Chemistry

DOI:https://doi.org/10.1021/acs.jmedchem.3c00314· OSTI ID:2423383

^[1]; ^[2]; ^[3]; Szewczyk, Magdalena M. ^[3]; ^[4]; Ferreira de Freitas, Renato ^[3]; Owens, Dominic D. G. ^[3]; ^[3]; Scheremetjew, Alexej ^[4]; Juarez-Ornelas, Kevin A. ^[4]; Sanichar, Randy ^[4]; ^[4]; Dank, Christian ^[4]; ^[3]; Barsyte-Lovejoy, Dalia ^[1]; ^[3]; ^[1]; ^[4]; ^[5]

Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada; Department of Pharmacology & Toxicology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
Davenport Research Laboratories, Department of Chemistry, University of Toronto, Toronto, Ontario M5S 3H6, Canada; Valence Discovery Inc., 6666 Rue St-Urbain, Suite 200, Montreal, Quebec H2S 3H1, Canada
Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada
Davenport Research Laboratories, Department of Chemistry, University of Toronto, Toronto, Ontario M5S 3H6, Canada
Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada; Princess Margaret Cancer Centre and Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 1L7, Canada

Not provided.

Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC02-06CH11357

OSTI ID:: 2423383

Journal Information:: Journal of Medicinal Chemistry, Journal Name: Journal of Medicinal Chemistry Journal Issue: 15 Vol. 66; ISSN 0022-2623

Publisher:: American Chemical Society (ACS)

Country of Publication:: United States

Language:: English

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