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Synthesis and Stereochemical Determination of the Peptide Antibiotic Novo29

Journal Article · · Journal of Organic Chemistry
 [1];  [1];  [1];  [2];  [2];  [1];  [1];  [2];  [2];  [2];  [3]
  1. Department of Chemistry, University of California, Irvine, Irvine, California92697, United States
  2. NovoBiotic Pharmaceuticals LLC, 767C Concord Avenue, Cambridge, Massachusetts02138, United States
  3. Department of Chemistry, University of California, Irvine, Irvine, California92697, United States; Department of Pharmaceutical Sciences, University of California, Irvine, Irvine, California92697, United States
+ Show Author Affiliations
Not provided.
Research Organization:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States). Advanced Light Source (ALS)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC02-05CH11231
OSTI ID:
2422740
Journal Information:
Journal of Organic Chemistry, Journal Name: Journal of Organic Chemistry Journal Issue: 4 Vol. 88; ISSN 0022-3263
Publisher:
American Chemical Society
Country of Publication:
United States
Language:
English

References (19)

A Fluorescent Teixobactin Analogue journal February 2020
Efficient preparation of β-hydroxy aspartic acid and its derivatives journal July 2018
X-ray crystallographic structure of a teixobactin analogue reveals key interactions of the teixobactin pharmacophore journal January 2017
Biosynthesis and Mechanism of Action of the Cell Wall Targeting Antibiotic Hypeptin journal May 2021
Efficient synthesis of chiral α,β-epoxyesters via a cyclic sulfate intermediate journal April 1998
Elucidation of the Teixobactin Pharmacophore journal May 2016
Synthesis of a protected derivative of (2R,3R)-β-hydroxyaspartic acid suitable for Fmoc-based solid phase synthesis journal January 2013
Teixobactin kills bacteria by a two-pronged attack on the cell envelope journal August 2022
Simple Method for the Esterification of Carboxylic Acids journal July 1978
Mode of action of teixobactins in cellular membranes journal June 2020
Structural studies suggest aggregation as one of the modes of action for teixobactin journal January 2018
X-ray Crystallographic Structure of a Teixobactin Derivative Reveals Amyloid-like Assembly journal October 2018
Design, Synthesis, and Study of Lactam and Ring-Expanded Analogues of Teixobactin journal November 2019
Vicinal diol cyclic sulfates. Like epoxides only more reactive journal October 1988
An Operationally Simple and Efficient Synthesis of Orthogonally Protected l-threo-β-Hydroxyasparagine journal June 2007
The cytotoxic Staphylococcus aureus PSMα3 reveals a cross-α amyloid-like fibril journal February 2017
Protection of carboxamide functions by the trityl residue. Application to peptide synthesis journal February 1991
A new antibiotic kills pathogens without detectable resistance journal January 2015
Alanine scan reveals modifiable residues in teixobactin journal January 2017

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Related Subjects

Chemistry