Surface Charge and Nanoparticle Chromophore Coupling to Achieve Fast Exciton Quenching and Efficient Charge Separation in Photoacoustic Imaging (PAI) and Photothermal therapy (PTT)

Liu, Zehan; Wen, Jiangping; Zhou, Guanqing; Xu, Jinqiu; Zhu, Lei; Zhang, Ming; Liu, Feng; Zhang, Yongming

doi:10.1002/adtp.202200168

Surface Charge and Nanoparticle Chromophore Coupling to Achieve Fast Exciton Quenching and Efficient Charge Separation in Photoacoustic Imaging (PAI) and Photothermal therapy (PTT)

Journal Article · 11 September 2022 · Advanced Therapeutics

DOI:https://doi.org/10.1002/adtp.202200168· OSTI ID:2422739

Liu, Zehan ^[1]; Wen, Jiangping ^[2]; Zhou, Guanqing ^[1]; Xu, Jinqiu ^[1]; Zhu, Lei ^[1]; Zhang, Ming ^[1]; ^[1]; Zhang, Yongming ^[1]

Frontiers Science Center for Transformative Molecules, Shanghai Key Laboratory of Electrical Insulation and Thermal Aging, School of Chemistry and Chemical Engineering Shanghai Jiao Tong University Shanghai 200240 China
Laboratory Medicine Department The First Hospital of Tsinghua University Beijing 100730 China

Abstract

An organic semiconductor nanoparticle (OSN) with surface charge strategy is proposed, which displays excellent photothermal conversion performance. The donor–acceptor hybrid organic semiconductor Y6 is selected as a photothermal chromophore into nanoparticle by self‐assembly, which affords long wavelength absorption, sub‐bandgap emission, and high photon‐to‐thermal conversion. Y6 in OSN adopts closed packing comparing to that in single crystal. The surface charge in OSN causes super‐quenching of the photon excitons, which enhances the nonradiative transition to improve photothermal effect. Lower energy level electronic states are created, which breaks up the bandgap limit and leads to long wavelength emission over 1100 nm. Photothermal therapy and photoacoustic imaging are applied successfully, indicating the success of the new methodology in designing photothermal conversion materials.

Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States). Advanced Light Source (ALS)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC02-05CH11231

OSTI ID:: 2422739

Journal Information:: Advanced Therapeutics, Journal Name: Advanced Therapeutics Journal Issue: 11 Vol. 5; ISSN 2366-3987

Country of Publication:: United States

Language:: English

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