Structure-Based Design of Transport-Specific Multitargeted One-Carbon Metabolism Inhibitors in Cytosol and Mitochondria

Nayeen, Md. Junayed; Katinas, Jade M.; Magdum, Tejashree; Shah, Khushbu; Wong, Jennifer E.; O’Connor, Carrie E.; Fifer, Alexandra N.; Wallace-Povirk, Adrianne; Hou, Zhanjun; Matherly, Larry H.; Dann, Charles E.; Gangjee, Aleem

doi:10.1021/acs.jmedchem.3c00763

Structure-Based Design of Transport-Specific Multitargeted One-Carbon Metabolism Inhibitors in Cytosol and Mitochondria

Journal Article · 15 August 2023 · Journal of Medicinal Chemistry

DOI:https://doi.org/10.1021/acs.jmedchem.3c00763· OSTI ID:2422735

Nayeen, Md. Junayed ^[1]; Katinas, Jade M. ^[2]; ^[1]; Shah, Khushbu ^[1]; Wong, Jennifer E. ^[2]; O’Connor, Carrie E. ^[3]; Fifer, Alexandra N. ^[2]; ^[3]; ^[4]; ^[4]; Dann, Charles E. ^[2]; ^[1]

Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania 15282, United States
Department of Chemistry, Indiana University, Bloomington, Indiana 47408, United States
Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan 48201, United States
Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan 48201, United States; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, 4100 John R, Detroit, Michigan 48201, United States

Not provided.

Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States). Advanced Light Source (ALS)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC02-05CH11231

OSTI ID:: 2422735

Journal Information:: Journal of Medicinal Chemistry, Journal Name: Journal of Medicinal Chemistry Journal Issue: 16 Vol. 66; ISSN 0022-2623

Publisher:: American Chemical Society (ACS)

Country of Publication:: United States

Language:: English

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