Skip to main content
U.S. Department of Energy
Office of Scientific and Technical Information

Enzymatic Hydroxylation of Aliphatic C–H Bonds by a Mn/Fe Cofactor

Journal Article · · Journal of the American Chemical Society
DOI:https://doi.org/10.1021/jacs.3c03419· OSTI ID:2422682
 [1];  [2];  [2];  [1]
  1. Department of Chemistry, University of California, Berkeley, Berkeley, California 94720, United States
  2. Department of Chemistry, University of California, Davis, Davis, California 95616, United States
Not provided.
Research Organization:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States). Advanced Light Source (ALS)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC02-05CH11231
OSTI ID:
2422682
Journal Information:
Journal of the American Chemical Society, Journal Name: Journal of the American Chemical Society Journal Issue: 30 Vol. 145; ISSN 0002-7863
Publisher:
American Chemical Society (ACS)
Country of Publication:
United States
Language:
English

References (60)

Survey of Branch Support Methods Demonstrates Accuracy, Power, and Robustness of Fast Likelihood-based Approximation Schemes journal May 2011
Self-sacrificial tyrosine cleavage by an Fe:Mn oxygenase for the biosynthesis of para -aminobenzoate in Chlamydia trachomatis journal September 2022
Enantioselective epoxidation of unfunctionalized olefins catalyzed by salen manganese complexes journal March 1990
Using evolutionary data to make sense of macromolecules with a “face‐lifted” ConSurf journal February 2023
Magnesium and Manganese Content of Halophilic Bacteria journal September 1986
Direct observation of structurally encoded metal discrimination and ether bond formation in a heterodinuclear metalloprotein journal October 2013
Phaser crystallographic software journal July 2007
The EFI Web Resource for Genomic Enzymology Tools: Leveraging Protein, Genome, and Metagenome Databases to Discover Novel Enzymes and Metabolic Pathways journal September 2019
Recovery of particulate methane monooxygenase structure and activity in a lipid bilayer journal March 2022
A Mycobacterium tuberculosis ligand-binding Mn/Fe protein reveals a new cofactor in a remodeled R2-protein scaffold journal April 2009
EasySpin, a comprehensive software package for spectral simulation and analysis in EPR journal January 2006
Dioxygen Activation by Enzymes Containing Binuclear Non-Heme Iron Clusters journal January 1996
Biochemical and Genetic Analysis of the γ-Resorcylate (2,6-Dihydroxybenzoate) Catabolic Pathway in Rhizobium sp. Strain MTP-10005: Identification and Functional Analysis of Its Gene Cluster journal March 2007
The Microbial Engines That Drive Earth's Biogeochemical Cycles journal May 2008
Evolution of Catalases from Bacteria to Humans journal September 2008
Gene Graphics: a genomic neighborhood data visualization web application journal December 2017
How do bacterial cells ensure that metalloproteins get the correct metal? journal January 2009
Aliphatic C–H Oxidations for Late-Stage Functionalization journal September 2018
A three-component monooxygenase from Rhodococcus wratislaviensis may expand industrial applications of bacterial enzymes journal January 2021
Manganese Lipoxygenase: PURIFICATION AND CHARACTERIZATION journal May 1998
Crystal structure of oxygen-evolving photosystem II at a resolution of 1.9 Å journal April 2011
Dioxygen Activation by Enzymes with Mononuclear Non-Heme Iron Active Sites journal January 1996
Oxygen sensing by HIF hydroxylases journal May 2004
Swapping metals in Fe- and Mn-dependent dioxygenases: Evidence for oxygen activation without a change in metal redox state journal May 2008
Key Structural Motifs Balance Metal Binding and Oxidative Reactivity in a Heterobimetallic Mn/Fe Protein journal February 2020
Characterization of 3-Ketosteroid 9α-Hydroxylase, a Rieske Oxygenase in the Cholesterol Degradation Pathway of Mycobacterium tuberculosis journal February 2009
Manganese Catalyzed C–H Halogenation journal May 2015
Structural Basis for Activation of Class Ib Ribonucleotide Reductase journal August 2010
Protein oxidation: key to bacterial desiccation resistance? journal February 2008
Interactive tree of life (iTOL) v3: an online tool for the display and annotation of phylogenetic and other trees journal April 2016
3,4-Dihydroxyphenylacetate 2,3-dioxygenase. A manganese(II) dioxygenase from Bacillus brevis. journal November 1981
A Manganese(IV)/Iron(III) Cofactor in Chlamydia trachomatis Ribonucleotide Reductase journal May 2007
NrdI, a flavodoxin involved in maintenance of the diferric-tyrosyl radical cofactor in Escherichia coli class Ib ribonucleotide reductase journal September 2008
Crystal Structure of Long-Chain Alkane Monooxygenase (LadA) in Complex with Coenzyme FMN: Unveiling the Long-Chain Alkane Hydroxylase journal February 2008
Water-Splitting Chemistry of Photosystem II journal November 2006
Metallation and mismetallation of iron and manganese proteins in vitro and in vivo: the class I ribonucleotide reductases as a case study journal January 2012
Superoxide Dismutases and Superoxide Reductases journal January 2014
NGPhylogeny.fr: new generation phylogenetic services for non-specialists journal April 2019
Dioxygen Activation and Methane Hydroxylation by Soluble Methane Monooxygenase: A Tale of Two Irons and Three Proteins journal August 2001
Structure and Reaction Mechanism of the LigJ Hydratase: An Enzyme Critical for the Bacterial Degradation of Lignin in the Protocatechuate 4,5-Cleavage Pathway journal September 2018
Structure and Action of the N-oxygenase AurF from Streptomyces thioluteus journal October 2007
Unipro UGENE: a unified bioinformatics toolkit journal February 2012
Biologically inspired oxidation catalysis journal September 2008
A novel class of fungal lipoxygenases journal November 2013
A graphical user interface to the CCP 4 program suite journal June 2003
Divergent assembly mechanisms of the manganese/iron cofactors in R2lox and R2c proteins journal September 2016
Dioxygen Activation by Nonheme Diiron Enzymes: Diverse Dioxygen Adducts, High-Valent Intermediates, and Related Model Complexes journal December 2017
Structure and Catalytic Mechanism of LigI: Insight into the Amidohydrolase Enzymes of cog3618 and Lignin Degradation journal April 2012
Overview of the CCP 4 suite and current developments journal March 2011
A Coupled Dinuclear Iron Cluster that Is Perturbed by Substrate Binding in myo -Inositol Oxygenase journal May 2006
NrdI Essentiality for Class Ib Ribonucleotide Reduction in Streptococcus pyogenes journal May 2008
MUSCLE: multiple sequence alignment with high accuracy and high throughput journal March 2004
Evidence That the β Subunit of Chlamydia trachomatis Ribonucleotide Reductase Is Active with the Manganese Ion of Its Manganese(IV)/Iron(III) Cofactor in Site 1 journal January 2012
Organophosphonate-degrading PhnZ reveals an emerging family of HD domain mixed-valent diiron oxygenases journal November 2013
Pulsed Multifrequency Electron Paramagnetic Resonance Spectroscopy Reveals Key Branch Points for One- vs Two-Electron Reactivity in Mn/Fe Proteins journal July 2022
Across the tree of life, radiation resistance is governed by antioxidant Mn 2+ , gauged by paramagnetic resonance journal October 2017
In vitro reconstitution and crystal structure of p-aminobenzoate N-oxygenase (AurF) involved in aureothin biosynthesis journal May 2008
Bacillus subtilis Class Ib Ribonucleotide Reductase Is a Dimanganese(III)-Tyrosyl Radical Enzyme journal June 2011
An Active Dimanganese(III)−Tyrosyl Radical Cofactor in Escherichia coli Class Ib Ribonucleotide Reductase journal February 2010
Characterization and Crystal Structure of a Nonheme Diiron Monooxygenase Involved in Platensimycin and Platencin Biosynthesis journal July 2019

Similar Records

Enzyme-Like Hydroxylation of Aliphatic C?H Bonds From an Isolable Co-Oxo Complex
Journal Article · 2021 · J. Am. Chem. Soc. · OSTI ID:1854202

Enzyme-Like Hydroxylation of Aliphatic C?H Bonds From an Isolable Co-Oxo Complex
Journal Article · 2021 · J. Am. Chem. Soc. · OSTI ID:1855480

Enzymatic Nitrogen Insertion into Unactivated C–H Bonds
Journal Article · 2022 · Journal of the American Chemical Society · OSTI ID:1891149

Related Subjects