Biolayer Interferometry Assay for Cyclin-Dependent Kinase-Cyclin Association Reveals Diverse Effects of Cdk2 Inhibitors on Cyclin Binding Kinetics

Tambo, Carrie S.; Tripathi, Sarvind; Perera, B. Gayani K.; Maly, Dustin J.; Bridges, Alexander J.; Kiss, Gert; Rubin, Seth M.

doi:10.1021/acschembio.3c00015

Biolayer Interferometry Assay for Cyclin-Dependent Kinase-Cyclin Association Reveals Diverse Effects of Cdk2 Inhibitors on Cyclin Binding Kinetics

Journal Article · 01 February 2023 · ACS Chemical Biology

DOI:https://doi.org/10.1021/acschembio.3c00015· OSTI ID:2422651

Tambo, Carrie S. ^[1]; ^[1]; Perera, B. Gayani K. ^[2]; ^[3]; Bridges, Alexander J. ^[4]; Kiss, Gert ^[4]; ^[1]

Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064, United States
Department of Chemistry, University of Washington, Seattle, Washington 98195, United States
Department of Chemistry, University of Washington, Seattle, Washington 98195, United States; Department of Biochemistry, University of Washington, Seattle, Washington 98195, United States
Type6 Therapeutics Inc., Santa Clara, California 95051, United States

Not provided.

Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States). Advanced Light Source (ALS)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC02-05CH11231

OSTI ID:: 2422651

Journal Information:: ACS Chemical Biology, Journal Name: ACS Chemical Biology Journal Issue: 2 Vol. 18; ISSN 1554-8929

Publisher:: American Chemical Society (ACS)

Country of Publication:: United States

Language:: English

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Biolayer Interferometry Assay for Cyclin-Dependent Kinase-Cyclin Association Reveals Diverse Effects of Cdk2 Inhibitors on Cyclin Binding Kinetics

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