Skip to main content
U.S. Department of Energy
Office of Scientific and Technical Information

Autoimmunity-associated T cell receptors recognize HLA-B*27-bound peptides

Journal Article · · Nature (London)
; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;

Not provided.

Research Organization:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States). Advanced Light Source (ALS)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC02-05CH11231
OSTI ID:
2422646
Journal Information:
Nature (London), Journal Name: Nature (London) Journal Issue: 7941 Vol. 612; ISSN 0028-0836
Publisher:
Nature Publishing Group
Country of Publication:
United States
Language:
English

References (62)

The microbiome and HLA-B27-associated acute anterior uveitis journal October 2018
High Association of an HL-A Antigen, W27, with Ankylosing Spondylitis journal April 1973
Deconstructing the Peptide-MHC Specificity of T Cell Recognition journal May 2014
Additional human β2‐microglobulin curbs HLA–B27 misfolding and promotes arthritis and spondylitis without colitis in male HLA–B27–transgenic rats journal March 2006
Enhanced Immune Presentation of a Single-chain Major Histocompatibility Complex Class I Molecule Engineered to Optimize Linkage of a C-terminally Extended Peptide journal July 2003
Hla-B27 journal March 2015
Features and development of Coot journal March 2010
HLA‐B27‐Restricted Cytotoxic T Lymphocyte Responses to Arthritogenic Enterobacteria or Self‐Antigens are Dominated by Closely Related TCRBV Gene Segments. A Study in Patients with Reactive Arthritis journal January 1996
Identification of T cell receptor recognition residues for a viral peptide presented by HLA B27 journal October 1994
The novel estrogen receptor G-protein-coupled receptor 30 is expressed in human bone journal May 2008
A possible link between Crohn’s disease and ankylosing spondylitis via Klebsiella infections journal August 2006
Cutting Edge: HLA-B27 Can Form a Novel β2-Microglobulin-Free Heavy Chain Homodimer Structure journal May 1999
Crystal structures and KIR3DL1 recognition of three immunodominant viral peptides complexed to HLA‐B*2705 journal January 2005
The development of Assessment of SpondyloArthritis international Society classification criteria for axial spondyloarthritis (part II): validation and final selection journal March 2009
A time- and cost-efficient system for high-level protein production in mammalian cells journal September 2006
HLA–B27 misfolding and the unfolded protein response augment interleukin‐23 production and are associated with Th17 activation in transgenic rats journal August 2009
Guilt by association: HLA-B27 and ankylosing spondylitis journal January 1990
Human TCR-Binding Affinity is Governed by MHC Class Restriction journal April 2007
Acute Anterior Uveitis and hl-a 27 journal November 1973
Th17 Cells Expressing KIR3DL2+ and Responsive to HLA-B27 Homodimers Are Increased in Ankylosing Spondylitis journal February 2011
Recognition of HLA-B27 and related antigen by a monoclonal antibody journal August 1982
Revisiting the Arthritogenic Peptide Theory: Quantitative Not Qualitative Changes in the Peptide Repertoire of HLA-B27 Allotypes: Unexpected Overlaps in the Binding Specificities of B27 Subtypes journal February 2015
Different TCRBV genes generate biased patterns of V-D-J diversity in human T cells journal January 1995
Multi-species single-cell transcriptomic analysis of ocular compartment regulons journal September 2021
TCR repertoire and CDR3 motif analyses depict the role of αβ T cells in Ankylosing spondylitis journal September 2019
Peptide Handling by HLA-B27 Subtypes Influences Their Biological Behavior, Association with Ankylosing Spondylitis and Susceptibility to Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) journal December 2014
Structure of the complex between human T-cell receptor, viral peptide and HLA-A2 journal November 1996
HLA-B27 Subtypes Differentially Associated with Disease Exhibit Subtle Structural Alterations journal December 2002
T cell receptor cross-reactivity between gliadin and bacterial peptides in celiac disease journal December 2019
Clinicomolecular Identification of Conserved and Individualized Features of Granulomatous Uveitis journal March 2021
Structural basis for clonal diversity of the human T-cell response to a dominant influenza virus epitope journal November 2017
CD8+ T cells with characteristic T cell receptor beta motif are detected in blood and expanded in synovial fluid of ankylosing spondylitis patients journal February 2018
MiXCR: software for comprehensive adaptive immunity profiling journal April 2015
Common Intra-Articular T Cell Expansions in Patients with Reactive Arthritis: Identical β-Chain Junctional Sequences and Cytotoxicity Toward HLA-B27 journal April 1999
GPR30 Estrogen Receptor Expression in the Growth Plate Declines as Puberty Progresses journal December 2007
Discovery of T Cell Receptor β Motifs Specific to HLA–B27–Positive Ankylosing Spondylitis by Deep Repertoire Sequence Analysis journal March 2017
The Link between Ankylosing Spondylitis, Crohn’s Disease, Klebsiella , and Starch Consumption journal January 2013
HL‐A 27 in reactive arthritis. A study of yersinia arthritis and Reiter's disease journal September 1974
TCRB Junctional regions from HLA-B27-restricted T cells and HLA-B27 binding peptides display conserved hydropathy profiles in the absence of primary sequence homology journal January 1996
HLA-B27-Associated Reactive Arthritis: Pathogenetic and Clinical Considerations journal April 2004
Towards error-free profiling of immune repertoires journal May 2014
Diverse T Cell Receptor Gene Usage in HLA-DQ8-Associated Celiac Disease Converges into a Consensus Binding Solution journal October 2016
Human Leukocyte Antigen (HLA) B27 Allotype-Specific Binding and Candidate Arthritogenic Peptides Revealed through Heuristic Clustering of Data-independent Acquisition Mass Spectrometry (DIA-MS) Data journal June 2016
Endoplasmic reticulum aminopeptidase 1 (ERAP1) trims MHC class I-presented peptides in vivo and plays an important role in immunodominance journal June 2006
Epidemic Reiter's syndrome following an outbreak of shigellosis journal March 1986
Conserved TCR β chain usage in reactive arthritis; evidence for selection by a putative HLA‐B27‐associated autoantigen journal October 2002
The Human Leukocyte Antigen (HLA)-B27 Peptidome in Vivo, in Spondyloarthritis-susceptible HLA-B27 Transgenic Rats and the Effect of Erap1 Deletion journal April 2017
Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix journal October 2019
HLA-A2-peptide complexes: refolding and crystallization of molecules expressed in Escherichia coli and complexed with single antigenic peptides. journal April 1992
Allelic association with ankylosing spondylitis fails to correlate with human leukocyte antigen B27 homodimer formation journal December 2019
Combined Effects of Ankylosing Spondylitis-associated ERAP1 Polymorphisms Outside the Catalytic and Peptide-binding Sites on the Processing of Natural HLA-B27 Ligands journal February 2014
Biased T Cell Receptor Usage Directed against Human Leukocyte Antigen DQ8-Restricted Gliadin Peptides Is Associated with Celiac Disease journal October 2012
Altered Repertoire Diversity and Disease‐Associated Clonal Expansions Revealed by T Cell Receptor Immunosequencing in Ankylosing Spondylitis Patients journal July 2020
The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8–9 residues journal November 2002
Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity journal May 2016
Persisting fetal clonotypes influence the structure and overlap of adult human T cell receptor repertoires journal July 2017
Genetic Dissection of Acute Anterior Uveitis Reveals Similarities and Differences in Associations Observed With Ankylosing Spondylitis journal December 2014
Reiter'S Disease and hl-a 27 journal November 1973
Old and new HLA associations with ankylosing spondylitis journal August 2012
Cell‐surface expression and immune receptor recognition of HLA–B27 homodimers journal November 2002
Sharing of T cell receptors in antigen-specific responses is driven by convergent recombination journal November 2006
Spontaneous inflammatory disease in transgenic rats expressing HLA-B27 and human β2m: An animal model of HLA-B27-associated human disorders journal November 1990

Similar Records

How a T Cell Receptor-like Antibody Recognizes Major Histocompatibility Complex-bound Peptide
Journal Article · 2007 · Journal of Biological Chemistry · OSTI ID:980243

Unusual features of Self-Peptide/MHC Binding by Autoimmune T Cell Receptors
Journal Article · 2004 · Immunity · OSTI ID:913921

UNCONVENTIONAL TOPOLOGY OF SELF PEPTIDE-MAJOR HISTOCOMPATIBILITY COMPLEX BINDING BY A HUMAN AUTOIMMUNE T CELL RECEPTOR
Journal Article · 2004 · J. AM. CERAM. SOC. · OSTI ID:884592