Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Sc-HOPO: A Potential Construct for Use in Radioscandium-Based Radiopharmaceuticals

Journal Article · · Inorganic Chemistry
 [1];  [2];  [3];  [3];  [3];  [4];  [3];  [3];  [4];  [5];  [2];  [2];  [2];  [6];  [2];  [7];  [5]
  1. Ph.D. Program in Chemistry, The Graduate Center of the City University of New York, New York, New York10016, United States; Department of Chemistry, City University of New York Hunter College, 695 Park Avenue, New York, New York10065, United States; Department of Chemistry, Lehman College of the City University of New York, Bronx, New York10468, United States; Program in Molecular Pharmacology and Chemistry, Memorial Sloan Kettering Cancer Center, New York, New York10065, United States; OSTI
  2. Department of Radiology, University of Alabama at Birmingham (UAB), Birmingham, Alabama35294, United States
  3. Department of Chemistry, City University of New York Hunter College, 695 Park Avenue, New York, New York10065, United States
  4. Medical Isotope Research and Production Laboratory, Collider−Accelerator Division, Brookhaven National Laboratory (BNL), Upton, New York11973, United States
  5. Ph.D. Program in Chemistry, The Graduate Center of the City University of New York, New York, New York10016, United States; Department of Chemistry, Lehman College of the City University of New York, Bronx, New York10468, United States
  6. Program in Molecular Pharmacology and Chemistry, Memorial Sloan Kettering Cancer Center, New York, New York10065, United States
  7. Ph.D. Program in Chemistry, The Graduate Center of the City University of New York, New York, New York10016, United States; Department of Chemistry, City University of New York Hunter College, 695 Park Avenue, New York, New York10065, United States
+ Show Author Affiliations

Not provided.

Research Organization:
Univ. of Alabama, Birmingham, AL (United States)
Sponsoring Organization:
USDOE Office of Science (SC)
DOE Contract Number:
SC0020197
OSTI ID:
2421468
Journal Information:
Inorganic Chemistry, Journal Name: Inorganic Chemistry Journal Issue: 50 Vol. 62; ISSN 0020-1669
Publisher:
American Chemical Society (ACS)
Country of Publication:
United States
Language:
English

References (46)

Chelation with a twist: a bifunctional chelator to enable room temperature radiolabeling and targeted PET imaging with scandium-44 journal January 2020
Evaluation of the first 44Sc-labeled Affibody molecule for imaging of HER2-expressing tumors journal February 2017
An exploratory scandium-45 NMR study into the complexation of alanine and oligopeptides journal January 1987
Ultra-selective ligand-driven separation of strategic actinides journal June 2019
AAZTA: An Ideal Chelating Agent for the Development of 44 Sc PET Imaging Agents journal January 2017
Reduced HOMO−LUMO Gap as an Index of Kinetic Stability for Polycyclic Aromatic Hydrocarbons journal September 1999
Revised effective ionic radii and systematic studies of interatomic distances in halides and chalcogenides journal September 1976
New Insights into Structure and Luminescence of Eu III and Sm III Complexes of the 3,4,3-LI(1,2-HOPO) Ligand journal February 2015
Comparative Toxicity of 3,4,3-LIHOPO and DTPA in Baboons: Preliminary Results journal May 1994
AAZTA5/AAZTA5-TOC: synthesis and radiochemical evaluation with 68Ga, 44Sc and 177Lu journal August 2019
Cyclotron Production and Separation of Scandium Radionuclides from Natural Titanium Metal and Titanium Dioxide Targets journal July 2020
Alternative Chelator for 89 Zr Radiopharmaceuticals: Radiolabeling and Evaluation of 3,4,3-(LI-1,2-HOPO) journal December 2013
Modeling Temperature Dependency of Amine Basicity Using PCM and SM8T Implicit Solvation Models journal February 2012
Evaluation of the inverse electron demand Diels-Alder reaction in rats using a scandium-44-labelled tetrazine for pretargeted PET imaging journal May 2019
Matching the Decay Half-Life with the Biological Half-Life: ImmunoPET Imaging with 44 Sc-Labeled Cetuximab Fab Fragment journal November 2014
Thermodynamic and Kinetic Study of Scandium(III) Complexes of DTPA and DOTA: A Step Toward Scandium Radiopharmaceuticals journal May 2014
Maximum carbonyl‐coordination number of scandium Computational study of Sc(CO)n (n = 1–7), Sc(CO)7− and Sc(CO)63− journal July 2012
Unraveling the Sc3+ Hydration Geometry: The Strange Case of the Far-Coordinated Water Molecule journal June 2016
Theoretical investigations on the HOMO–LUMO gap and global reactivity descriptor studies, natural bond orbital, and nucleus-independent chemical shifts analyses of 3-phenylbenzo[d]thiazole-2(3H)-imine and its para-substituted derivatives: Solvent and substituent effects journal June 2020
Influence of metal ions on the 44Sc-labeling of DOTATATE journal August 2019
Explicitly Representing the Solvation Shell in Continuum Solvent Calculations journal May 2009
44 Sc: An Attractive Isotope for Peptide-Based PET Imaging journal July 2014
44Sc-PSMA-617 for radiotheragnostics in tandem with 177Lu-PSMA-617—preclinical investigations in comparison with 68Ga-PSMA-11 and 68Ga-PSMA-617 journal January 2017
Scandium( iii ) complexes of monophosphorus acid DOTA analogues: a thermodynamic and radiolabelling study with 44 Sc from cyclotron and from a 44 Ti/ 44 Sc generator journal January 2016
44Sc for labeling of DOTA- and NODAGA-functionalized peptides: preclinical in vitro and in vivo investigations journal May 2016
Developing scandium and yttrium coordination chemistry to advance theranostic radiopharmaceuticals journal May 2020
From early prophylaxis to delayed treatment: Establishing the plutonium decorporation activity window of hydroxypyridinonate chelating agents journal April 2017
The interaction of Sc(OH)2+·aq with serine and small peptides investigated by 45Sc NMR spectroscopy journal April 1989
Biomimetic Actinide Chelators: an Update on the Preclinical Development of the Orally Active Hydroxypyridonate Decorporation Agents 3,4,3-Li(1,2-Hopo) and 5-Lio(Me-3,2-Hopo) journal January 2010
Stability of 47Sc-complexes with acyclic polyamino-polycarboxylate ligands journal September 2012
Synthesis and Initial Evaluation for In Vivo Chelation of Pu(IV) of a Mixed Octadentate Spermine-Based Ligand Containing 4-Carbamoyl-3-hydroxy-1-methyl-2(1 H )-pyridinone and 6-Carbamoyl-1-hydroxy-2(1 H )-pyridinone journal August 2002
Chemical and biological evaluation of scandium(III)-polyaminopolycarboxylate complexes as potential PET agents and radiopharmaceuticals journal June 2011
A comparative thermodynamic study of the formation of scandium complexes with DTPA and DOTA journal January 2015
Improved synthesis of the bifunctional chelator p -SCN-Bn-HOPO journal January 2019
Clinical Translation and First In-Human Use of [ 44 Sc]Sc-PSMA-617 for PET Imaging of Metastasized Castrate-Resistant Prostate Cancer journal January 2017
Promising Prospects for 44Sc-/47Sc-Based Theragnostics: Application of 47Sc for Radionuclide Tumor Therapy in Mice journal July 2014
p -SCN-Bn-HOPO: A Superior Bifunctional Chelator for 89 Zr ImmunoPET journal November 2015
A new mixing of Hartree–Fock and local density‐functional theories journal January 1993
Energies, structures, and electronic properties of molecules in solution with the C-PCM solvation model journal April 2003
Self—Consistent Molecular Orbital Methods. XII. Further Extensions of Gaussian—Type Basis Sets for Use in Molecular Orbital Studies of Organic Molecules journal March 1972
New Bisaqua Picolinate-Based Gadolinium Complexes as MRI Contrast Agents with Substantial High-Field Relaxivities journal January 2012
Therapeutic Potential of 47Sc in Comparison to 177Lu and 90Y: Preclinical Investigations journal August 2019
Matching chelators to radiometals for radiopharmaceuticals journal January 2014
Revised Basis Sets for the LANL Effective Core Potentials journal June 2008
Underscoring the Influence of Inorganic Chemistry on Nuclear Imaging with Radiometals journal December 2013
Structural properties of scandium inorganic salts journal June 2017

Similar Records

Related Subjects

Chemistry