Skip to main content
U.S. Department of Energy
Office of Scientific and Technical Information

The discovery of rubisco

Journal Article · · Journal of Experimental Botany
DOI:https://doi.org/10.1093/jxb/erac254· OSTI ID:2419367

Abstract

Rubisco is possibly the most important enzyme on Earth, certainly in terms of amount. This review describes the initial reports of ribulose 1,5-bisphosphate carboxylating activity. Discoveries of core concepts are described, including its quaternary structure, the requirement for post-translational modification, and its role as an oxygenase as well as a carboxylase. Finally, the requirement for numerous chaperonins for assembly of rubisco in plants is described.

Research Organization:
Michigan State Univ., East Lansing, MI (United States)
Sponsoring Organization:
USDOE Office of Science (SC)
DOE Contract Number:
FG02-91ER20021
OSTI ID:
2419367
Journal Information:
Journal of Experimental Botany, Journal Name: Journal of Experimental Botany Journal Issue: 2 Vol. 74; ISSN 0022-0957
Publisher:
Oxford University Press
Country of Publication:
United States
Language:
English

References (111)

IDENTIFICATION OF RIBULOSE IN C 14 O 2 PHOTOSYNTHESIS PRODUCTS 1 journal June 1951
Forty years of photosynthesis and related activities journal July 1989
Enzymatic Regulation of Photosynthetic CO2, Fixation in C3 Plants journal June 1988
Water and Solutes in Plant Nutrition: With Special Reference to van Helmont and Nicholas of Cusa journal April 1968
Plants increase CO2 uptake by assimilating nitrogen via the photorespiratory pathway journal December 2017
Ribulose-1,5-diphosphate from and CO2 fixation by Tetragonia expansa leaves extract journal January 1957
Localization of mRNAs for the Small and Large Subunits of Rubisco Using Electron Microscopic in Situ Hybridization journal April 1988
Binding of a Phosphorylated Inhibitor to Ribulose Bisphosphate Carboxylase/Oxygenase during the Night journal August 1985
Regulation of Soybean Net Photosynthetic CO 2 Fixation by the Interaction of CO 2 , O 2 , and Ribulose 1,5-Diphosphate Carboxylase journal November 1974
Fraction I Protein journal June 1970
Pyruvate is a by-product of catalysis by ribulosebisphosphate carboxylase/oxygenase journal May 1991
Genetic Dissection of Rubisco Structure and Function journal June 1993
The Path of Carbon in Photosynthesis. XXI. The Cyclic Regeneration of Carbon Dioxide Acceptor 1 journal April 1954
Rubisco is not really so bad: Rubisco efficiency journal February 2018
From Chloroplasts to Chaperones: How One Thing Led to Another journal January 2004
Photorespiration in the context of Rubisco biochemistry, CO 2 diffusion and metabolism journal January 2020
The path of Carbon in Photosynthesis journal June 1952
Limitation of Photosynthesis by Carbon Metabolism: II. O journal August 1986
The Photosynthetic Cycle. CO 2 Dependent Transients journal November 1955
Structure, Function, Regulation, and Assembly of D-Ribulose-1,5-Bisphosphate Carboxylase/Oxygenase journal June 1994
Species variation in the specificity of ribulose biphosphate carboxylase/oxygenase journal June 1981
Celebrating Andrew Alm Benson’s 93rd birthday journal September 2010
A biochemical model of photosynthetic CO2 assimilation in leaves of C3 species journal June 1980
Variations in Kinetic Properties of Ribulose-1,5-bisphosphate Carboxylases among Plants journal June 1981
R UBISCO : Structure, Regulatory Interactions, and Possibilities for a Better Enzyme journal June 2002
Directed Mutagenesis of Chloroplast Ribulose-1,5-bisphosphate Carboxylase/Oxygenase journal August 1996
Maize chloroplast DNA fragment encoding the large subunit of ribulosebisphosphate carboxylase journal December 1977
Biogenesis and Metabolic Maintenance of Rubisco journal April 2017
Regulation of Ribulose 1,5-Bisphosphate Carboxylase/Oxygenase Activity journal June 1992
A Model Describing the Regulation of Ribulose-1,5-Bisphosphate Carboxylase, Electron Transport, and Triose Phosphate Use in Response to Light Intensity and CO2 in C3 Plants journal December 1990
Last days in the old radiation laboratory (ORL), Berkeley, California, 1954 journal September 2010
Chemical and Enzymatic Evidence for the Participation of a 2-Carboxy-3-ketoribitol-1,5-diphosphate Intermediate in the Carboxylation of Ribulose 1,5-Diphosphate journal August 1973
Plant RuBisCo assembly in E. coli with five chloroplast chaperones including BSD2 journal December 2017
Sliding-layer conformational change limited by the quaternary structure of plant RuBisCO journal September 1987
A role for ribulose‐1,5‐bisphosphate carboxylase as a metabolite buffer journal August 1982
Discoveries in Rubisco (Ribulose 1,5-bisphosphate carboxylase/oxygenase): a historical perspective journal July 2007
The in-vivo response of the ribulose-1,5-bisphosphate carboxylase activation state and the pool sizes of photosynthetic metabolites to elevated CO2 inPhaseolus vulgaris L. journal June 1988
Synthesis of Carbohydrates from Carbon Dioxide and Hydrogen in a Cell-Free System journal February 1955
A model of the subunit structure of fraction I protein journal December 1970
Regulation of ribulose bisphosphate carboxylase activity in vivo by a light-modulated inhibitor of catalysis journal December 1985
The path of carbon in photosynthesis: XX. The steady state journal December 1952
Activity Ratios of Ribulose-1,5-Bisphosphate Carboxylase Accurately Reflect Carbamylation Ratios journal March 1989
The Active Species of “CO2” Utilized by Ribulose Diphosphate Carboxylase journal February 1969
The evolution of C 4 photosynthesis journal February 2004
An Early Arabidopsis Demonstration. Resolving a Few Issues Concerning Photorespiration: Fig. 1. journal January 2001
Subunit control of Rubisco biosynthesis – a relic of an endosymbiotic past? journal January 1999
Early events along the trail leading to identification of rubisco journal February 1992
The reductive pentose phosphate cycle journal January 1957
Photorespiration: Pathways, Regulation, and Modification journal June 1984
The identification of carbon dioxide mediated protein post-translational modifications journal August 2018
Photorespiratory Metabolism: Genes, Mutants, Energetics, and Redox Signaling journal June 2009
Slow Inactivation of Ribulosebisphosphate Carboxylase during Catalysis Is Caused by Accumulation of a Slow, Tight-Binding Inhibitor at the Catalytic Site journal August 1990
PENTOSE PHOSPHATE AND CO2 FIXATION WITH SPINACH EXTRACTS journal July 1954
The Costs of Photorespiration to Food Production Now and in the Future journal April 2016
The Carboxylation and Oxygenation of Ribulose 1,5-Bisphosphate: The Primary Events in Photosynthesis and Photorespiration journal June 1981
Rate-limiting factors in leaf photosynthesis. I. Carbon fluxes in the calvin cycle journal December 1984
The structure of form I crystals of d-ribulose-1,5-diphosphate carboxylase journal February 1975
A nocturnal inhibitor of carboxylation in leaves journal November 1986
Chloroplast DNA codes for the primary structure of the large subunit of Fraction I protein journal September 1972
The effect of oxygen on the reduction of CO2 to glycolic acid and other products during photosynthesis by Chlorella journal November 1962
Synthetic glycolate metabolism pathways stimulate crop growth and productivity in the field journal January 2019
2′-Carboxy-D-arabitinol 1-phosphate protects ribulose 1,5-bisphosphate carboxylase/oxygenase against proteolytic breakdown: CA1P protects Rubisco against proteolysis journal December 1999
Interaction of sugar phosphates with the catalytic site of ribulose-1,5-bisphosphate carboxylase journal April 1981
Current methods for estimating the rate of photorespiration in leaves journal November 2012
Advancing Our Understanding and Capacity to Engineer Nature’s CO 2 -Sequestering Enzyme, Rubisco journal October 2010
Rapid heating of intact leaves reveals initial effects of stromal oxidation on photosynthesis journal June 2007
Purification and Species Distribution of Rubisco Activase journal July 1987
The activation of ribulose-1,5-bisphosphate carboxylase by carbon dioxide and magnesium ions. Equilibria, kinetics, a suggested mechanism, and physiological implications journal February 1976
Interactions between ribulose-1,5-bisphosphate carboxylase and stromal metabolites. II. Corroboration of the role of this enzyme as a metabolite buffer journal November 1987
Remembering James Alan Bassham (1922–2012) journal November 2015
The Proteins of Green Leaves journal December 1957
Isolation, identification, and synthesis of 2-carboxyarabinitol 1-phosphate, a diurnal regulator of ribulose-bisphosphate carboxylase activity journal February 1987
Activation of Ribulose 1,5-Diphosphate Carboxylase by Nicotinamide Adenine Dinucleotide Phosphate and Other Chloroplast Metabolites journal October 1974
Studies on fraction I protein IV. Mode of inheritance of primary structure in relation to whether chloroplast or nuclear DNA contains the code for a chloroplast protein journal February 1972
Subunits From Reduced and S-Carboxymethylated Ribulose Diphosphate Carboxylase (Fraction I Protein) journal January 1969
Along the trail from Fraction I protein to Rubisco (ribulose bisphosphate carboxylase-oxygenase) journal July 2002
Photorespiratory nitrogen cycle journal October 1978
Distinct form I, II, III, and IV Rubisco proteins from the three kingdoms of life provide clues about Rubisco evolution and structure/function relationships journal June 2007
Ribulose Diphosphate Carboxylase from Freshly Ruptured Spinach Chloroplasts Having an in Vivo Km[CO2] journal January 1974
Regulation of Rubisco by inhibitors in the light journal April 1997
Ribulose 1,5-Bisphosphate Carboxylase-Oxygenase journal June 1977
Mechanism of Enzyme Repair by the AAA+ Chaperone Rubisco Activase journal September 2017
The stereochemical course of ribulosebisphosphate carboxylase. Reductive trapping of the 6-carbon reaction-intermediate. journal May 1982
The most abundant protein in the world journal November 1979
Photosynthesis and Ribulose 1,5-Bisphosphate Concentrations in Intact Leaves of Xanthium strumarium L. journal December 1984
Pathways of Carbon Fixation in Green Plants journal June 1975
Estimating the rate of photorespiration in leaves journal May 1988
A conversation with Andrew Benson: reflections on the discovery of the Calvin–Benson cycle journal December 2012
Formation of 3-Phosphoglyceric acid by Carbon Dioxide Fixation with Spinach leaf Enzymes journal February 1956
Manganese binding to Rubisco could drive a photorespiratory pathway that increases the energy efficiency of photosynthesis journal July 2018
Nonidentical subunits of ribulose diphosphate carboxylase journal August 1967
THE C 2 OXIDATIVE PHOTOSYNTHETIC CARBON CYCLE journal June 1997
Rubisco activase – Rubisco's catalytic chaperone journal January 2003
Dissociation of the ribulosebisphosphate-carboxylase large-subunit binding protein into dissimilar subunits journal March 1987
New Insights into the Mechanism of Chloroplast Protein Import and Its Integration with Protein Quality Control, Organelle Biogenesis and Development journal March 2015
Carbon Dioxide Fixation By Green Plants journal June 1950
ENZYMATIC CARBOXYLATION OF RIBULOSE DIPHOSPHATE 1 journal July 1954
Protein carbamylation is a hallmark of aging journal December 2015
Regulation of Ribulose 1,5-Diphosphate Carboxylase by Substrates and Other Metabolites journal April 1975
Models describing the kinetics of ribulose biphosphate carboxylase-oxygenase journal April 1979
Slow Inactivation of Ribulosebisphosphate Carboxylase during Catalysis Is Not Due to Decarbamylation of the Catalytic Site journal August 1990
Stomatal Conductance and Photosynthesis journal June 1982
Photosynthesis with Radio-Carbon journal December 1939
Source of 12C in Calvin–Benson cycle intermediates and isoprene emitted from plant leaves fed with 13CO2 journal September 2020
Discovery of the canonical Calvin–Benson cycle journal October 2018
Mechanism of Rubisco:  The Carbamate as General Base journal April 1998
Phosphoglycolate production catalyzed by ribulose diphosphate carboxylase journal November 1971
The Enzymatic Formation of Phosphoglyceric acid from Ribulose Diphosphate and Carbon Dioxide journal February 1956
Transformation of Sugars in Plants journal June 1950
Reconstitution of active dimeric ribulose bisphosphate carboxylase from an unfolded state depends on two chaperonin proteins and Mg-ATP journal December 1989
Ribulose-1,5-Bisphosphate Carboxylase-Oxygenase journal June 1983