Added Value of Internal Fragments for Top-Down Mass Spectrometry of Intact Monoclonal Antibodies and Antibody–Drug Conjugates

Wei, Benqian; Lantz, Carter; Liu, Weijing; Viner, Rosa; Ogorzalek Loo, Rachel R.; Campuzano, Iain D.  G.; Loo, Joseph A.

doi:10.1021/acs.analchem.3c01426

Added Value of Internal Fragments for Top-Down Mass Spectrometry of Intact Monoclonal Antibodies and Antibody–Drug Conjugates

Journal Article · 06 June 2023 · Analytical Chemistry

DOI:https://doi.org/10.1021/acs.analchem.3c01426· OSTI ID:2418845

^[1]; Lantz, Carter ^[2]; ^[3]; Viner, Rosa ^[3]; ^[4]; ^[5]; ^[6]

Department of Chemistry and Biochemistry, University of California─Los Angeles, Los Angeles, California 90095, United States; OSTI
Department of Chemistry and Biochemistry, University of California─Los Angeles, Los Angeles, California 90095, United States
Thermo Fisher Scientific, San Jose, California 95134, United States
Department of Chemistry and Biochemistry, University of California─Los Angeles, Los Angeles, California 90095, United States; UCLA-DOE Institute, University of California─Los Angeles, Los Angeles, California 90095, United States; Molecular Biology Institute, University of California─Los Angeles, Los Angeles, California 90095, United States
Center for Research Acceleration and Digital Innovation, Molecular Analytics, Amgen Research, Thousand Oaks, California 91320, United States
Department of Chemistry and Biochemistry, University of California─Los Angeles, Los Angeles, California 90095, United States; Department of Biological Chemistry, University of California─Los Angeles, Los Angeles, California 90095, United States; UCLA-DOE Institute, University of California─Los Angeles, Los Angeles, California 90095, United States; Molecular Biology Institute, University of California─Los Angeles, Los Angeles, California 90095, United States

Not provided.

Research Organization:: Univ. of California, Los Angeles, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC)

DOE Contract Number:: FC02-02ER63421

OSTI ID:: 2418845

Journal Information:: Analytical Chemistry, Journal Name: Analytical Chemistry Journal Issue: 24 Vol. 95; ISSN 0003-2700

Publisher:: American Chemical Society (ACS)

Country of Publication:: United States

Language:: English

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