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Latent bone modelling for estimation of plutonium concentration in skeleton of former nuclear workers

Journal Article · · Radiation Protection Dosimetry
DOI:https://doi.org/10.1093/rpd/ncad069· OSTI ID:2418456
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Abstract

The skeleton is a major plutonium retention site in the human body. Estimation of the total plutonium activity in the skeleton is a challenging problem. For most tissue donors at the United States Transuranium and Uranium Registries, a limited number of bone samples is available. The skeleton activity is calculated using plutonium activity concentration (Cskel) and skeleton weight. In this study, latent bone modelling was used to estimate Cskel from the limited number of analysed bone samples. Data from 13 non-osteoporotic whole-body donors were used to develop latent bone model (LBM) to estimate Cskel for seven cases with four to eight analysed bone samples. LBM predictions were compared to Cskel estimated using an arithmetic mean in terms of accuracy and precision. For the studied cases, LBM offered a significant reduction of uncertainty of Cskel estimate.

Research Organization:
Washington State Univ., Pullman, WA (United States)
Sponsoring Organization:
USDOE Office of Environment, Health, Safety and Security (AU)
DOE Contract Number:
HS0000073
OSTI ID:
2418456
Journal Information:
Radiation Protection Dosimetry, Journal Name: Radiation Protection Dosimetry Journal Issue: 8-9 Vol. 199; ISSN 0144-8420
Publisher:
Oxford University Press
Country of Publication:
United States
Language:
English

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