Mapping of the pulmonary surfactant SP5 (SFTP2) locus to 8p21 and characterization of a microsatellite repeat marker that shows frequent loss of heterozygosity in human carcinomas
- Univ. of British Columbia (Canada)
- Univ. of Chicago, IL (United States); and others
We have identified 4 cosmids at the SFTP2 locus by cDNA hybridization. SFTP2 was mapped using a polymorphic CA repeat and localized to 8p21 by FISH. Allele loss in carcinomas was detected using this PCR marker. Among 11 lung and colon tumors, 6 of 9 informative cases exhibited allelic loss. 22 refs., 3 figs., 1 tab.
- OSTI ID:
- 241049
- Journal Information:
- Genomics, Vol. 24, Issue 3; Other Information: PBD: Dec 1994
- Country of Publication:
- United States
- Language:
- English
Similar Records
Human pituitary adenomas show no loss of heterozygosity at the retinoblastoma gene locus
A high-resolution map of genes, microsatellite markers, and new dinucleotide repeats from UBE1 to the GATA locus in the region Xp11.23
Loss of heterozygosity and microsatellite instability in chromosomal segments commonly deleted in squamous cell carcinoma
Journal Article
·
Fri Apr 01 00:00:00 EST 1994
· Journal of Clinical Endocrinology and Metabolism
·
OSTI ID:241049
+3 more
A high-resolution map of genes, microsatellite markers, and new dinucleotide repeats from UBE1 to the GATA locus in the region Xp11.23
Journal Article
·
Fri Sep 01 00:00:00 EDT 1995
· Genomics
·
OSTI ID:241049
Loss of heterozygosity and microsatellite instability in chromosomal segments commonly deleted in squamous cell carcinoma
Journal Article
·
Thu Sep 01 00:00:00 EDT 1994
· American Journal of Human Genetics
·
OSTI ID:241049