New microsatellite polymorphisms identified between C57BL/6, C57BL/10, and C57BL/KsJ inbred mouse strains
- Hammersmith Hospital, London (United Kingdom); and others
The C57BL/6 (B6) and C57BL/10 (B10) inbred mouse strains are among the most commonly used in biological research and have provided the genetic background for the construction of many congenic strains. The two substrains were derived from the parental C57BL stock and were separated prior to 1937. Since then, they have been thought to possess a very close genetic relationship. By 1992, 161 loci had been tested, and only three differed between B6 and B10: the minor histocompatibility locus H9, the immunoglobulin heavy chain locus Igh 2 on chromosome 12, and the delta-aminolevulinate dehydratase Lv locus on chromosome 4. B6 and B10 have also been shown to differ over an 8 cM segment on chromosome 4. Due to the differences at the H9 locus, B6 and B10 are not histocompatible. The aim of our study was to identify novel genetic polymorphisms between B6 and B10 mice and to analyze the BKs mouse with genetic markers such that further information can be gathered on the genetic origins of this strain. 13 refs., 3 figs.
- OSTI ID:
- 240994
- Journal Information:
- Immunogenetics, Vol. 43, Issue 1-2; Other Information: PBD: 1996
- Country of Publication:
- United States
- Language:
- English
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