Biological neutron scattering: Now and the future
Neutrons have an important role to play in structural biology. Neutron crystallography, small-angle neutron scattering and inelastic neutron scattering techniques can all contribute unique information on biomolecular structures. In particular, solution scattering techniques can give critical information on the conformations an dispositions of the components of complex assemblies under a wide variety of relevant conditions. The power of these methods are demonstrated for examples by protein/DNA complexes, and Ca{sup 2+}- binding proteins complexed with their regulatory targets. In addition, we demonstrate the utility of a new structural approach suing neutron resonance scattering. The impact of biological neutron scattering to date has been constrained principally by the available fluxes at neutron sources and the true potential of these approaches will only be realized with the development of new more powerful neutron sources.
- Research Organization:
- Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
- Sponsoring Organization:
- National Insts. of Health, Bethesda, MD (United States)
- DOE Contract Number:
- W-7405-ENG-36
- OSTI ID:
- 238087
- Report Number(s):
- LA-UR-96-1433; CONF-9603162-3; ON: DE96010493
- Resource Relation:
- Conference: International workshop on science in neutron-arena of JHP, Tsukuba (Japan), 26-27 Mar 1996; Other Information: PBD: [1996]
- Country of Publication:
- United States
- Language:
- English
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