MicroRNA-3662 expression correlates with antiviral drug resistance in adult T-cell leukemia/lymphoma cells
- Department of Molecular Microbiology and Immunology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, 852-8523 (Japan)
- Department of Biochemistry, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, 852-8523 (Japan)
- Department of Oncology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, 852-8523 (Japan)
Highlights: • IRF-4 and c-Rel cooperate in antiviral drug resistance of ATLL. • Expression of miR-3662 was regulated by IRF4 and to a lesser extent by c-Rel. • Expression of miR-3662 was correlated with antiviral drug resistance in ATLL cell lines. Interferon regulatory factor (IRF) 4 and the proto-oncogene c-Rel cooperate in growth and antiviral drug resistance of adult T-cell leukemia/lymphoma (ATLL). To elucidate the target of IRF4 and c-Rel in ATLL, we determined the simultaneous binding sites of IRF4 and c-Rel using ChIP-seq technology. Nine genes were identified within 2 kb of binding sites, including MIR3662. Expression of miR-3662 was regulated by IRF4, and to a lesser extent by c-Rel. Cell proliferation was inhibited by knockdown of miR-3662 and expression of miR-3662 was correlated with antiviral drug resistance in ATLL cell lines. Thus, miR-3662 represents a target for therapies against ATLL.
- OSTI ID:
- 23137011
- Journal Information:
- Biochemical and Biophysical Research Communications, Vol. 501, Issue 4; Other Information: Copyright (c) 2018 Elsevier Inc. All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); ISSN 0006-291X
- Country of Publication:
- United States
- Language:
- English
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