miR-20a inhibits the killing effect of natural killer cells to cervical cancer cells by downregulating RUNX1
- Department of Obstetrics and Gynecology, Affiliated Jiangyin Hospital of South-East University, Jiangyin, 214400 (China)
- Department of Oncology, Affiliated Jiangyin Hospital of South-East University, Jiangyin, 214400 (China)
Highlights: • MiR-20a was upregulated while RUNX1 was downregulated in NK cells from cervical cancer patients. • MiR-20a attenuated the natural killing effect of NK cells to cervical cancer cells. • RUNX1 was targeted by miR-20a. • MiR-20a inhibited the natural killing effect of NK cells to cervical cancer cells via targeting RUNX1. NK cells are presented in tumor microenvironments and acts as an essential defense line against multiple malignancies. Recently, miRNAs are reported to involve in the development of natural killer (NK) cells via negatively regulating gene expression. Here, we aim to explore the function and mechanism underlying how miR-20a modulated the killing effect of NK cells to cervical cancer cells.
- OSTI ID:
- 23134147
- Journal Information:
- Biochemical and Biophysical Research Communications, Vol. 505, Issue 1; Other Information: Copyright (c) 2018 Elsevier Inc. All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); ISSN 0006-291X
- Country of Publication:
- United States
- Language:
- English
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