Accelerating Engineered Microbe Optimization through Machine Learning and Multi-Omics Datasets [Abstract]
- Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
The Agile Biofoundry (ABF) is a multi-national lab consortium funded by the DOE Bioenergy Technologies Office that has developed a biofoundry enabling the rapid deployment of bioproducts into the market. The ABF is a flexible platform that can adjust to the needs of numerous government, academic and industrial partners, thus enabling them to rapidly develop and optimize the production of a wide range of bioproducts. To demonstrate this capability, three ABF labs (NTESS, LBNL, and PNNL) have collaborated with the biomanufacturer Lygos, Inc. to use the ABF to demonstrate a high-throughput Design-Build-Test-Learn (DBTL) engineering cycle incorporating multi-omics analysis and machine learning with best in industry cycle times.
- Research Organization:
- Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Lygos, Inc., Berkeley, CA (United States); Sandia National Laboratories (SNL-CA), Livermore, CA (United States); Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AC05-76RL01830
- OSTI ID:
- 2293577
- Report Number(s):
- PNNL--35277; CRADA-422; PNNL-73026
- Country of Publication:
- United States
- Language:
- English
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