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Title: The Sentinel Lymph Node Biopsy Using Indocyanine Green Fluorescence Plus Radioisotope Method Compared With the Radioisotope-Only Method for Breast Cancer Patients After Neoadjuvant Chemotherapy: A Prospective, Randomized, Open-Label, Single-Center Phase 2 Trial

Abstract

Background: This study aimed to compare the sentinel lymph node (SLN) identification rates for breast cancer patients after neoadjuvant chemotherapy (NAC) between the dual method (DM) of indocyanine green fluorescence (ICG-F) plus a radioisotope (RI) and RI alone. Methods: This randomized study enrolled 130 patients who received NAC for breast cancer and 122 patients who received SLN biopsy (SLNB) using either DM (n = 58) or RI only (n = 64). The study compared the identification rate, number of SLNs, and detection time of SLNB. Results: Among the 122 patients, 113 (92.6%) were clinically node-positive before NAC. The SLN identification rate was 98.3% in the DM group and 93.8% in the RI group (p = 0.14). The DM group and the RI group were similar in the average number of SLNs (2.2 ± 1.13 vs. 1.9 ± 1.33; p = 0.26) and the time to detection of the first SLN (8.7 ± 4.98 vs. 8.3 ± 4.31 min; p = 0.30). In the DM group, transcutaneous lymphatic drainage was visualized by fluorescence imaging for 65.5% (38 of 58) of the patients. The SLN identification rate was 94.7% using ICG-F and 93% using RI (p = 0.79). During and after the operation, no complications, including allergic reactions or skin necrosis, occurred. Conclusions: This study is the first randomized trial to use ICG-Fmore » for SLNB in breast cancer patients after NAC. The DM including ICG-F could be a feasible and safe method for SLNB in initially node-positive breast cancer patients with NAC.« less

Authors:
;  [1];  [2]; ; ;  [1];  [3]; ; ; ; ; ; ;  [1];  [4]; ;  [1]
  1. National Cancer Center, Center for Breast Cancer (Korea, Republic of)
  2. Wonkwang University Sanbon Hospital, Department of Surgery (Korea, Republic of)
  3. Keimyung University School of Medicine, Department of Surgery (Korea, Republic of)
  4. National Cancer Center, Biometrics Research Branch, Division of Cancer Epidemiology and Management Research Institute (Korea, Republic of)
Publication Date:
OSTI Identifier:
22927646
Resource Type:
Journal Article
Journal Name:
Annals of Surgical Oncology (Online)
Additional Journal Information:
Journal Volume: 26; Journal Issue: 8; Other Information: Copyright (c) 2019 Society of Surgical Oncology; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 1534-4681
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BIOPSY; CHEMOTHERAPY; FLUORESCENCE; INDOCYANINE GREEN; LYMPH NODES; MAMMARY GLANDS; NECROSIS; NEOPLASMS; PATIENTS; SKIN

Citation Formats

Jung, So-Youn, Han, Jai Hong, Park, Soo Jin, Lee, Eun-Gyeong, Kwak, Joohwa, Kim, Sun Hye, Lee, Moo Hyun, Lee, Eun Sook, Kang, Han-Sung, Lee, Keun Seok, Park, In Hae, Sim, Sung Hoon, Jeong, Hae Jeong, Kwon, Youngmee, Lee, Dong-Eun, Kim, Seok-Ki, and Lee, Seeyoun. The Sentinel Lymph Node Biopsy Using Indocyanine Green Fluorescence Plus Radioisotope Method Compared With the Radioisotope-Only Method for Breast Cancer Patients After Neoadjuvant Chemotherapy: A Prospective, Randomized, Open-Label, Single-Center Phase 2 Trial. United States: N. p., 2019. Web. doi:10.1245/S10434-019-07400-0.
Jung, So-Youn, Han, Jai Hong, Park, Soo Jin, Lee, Eun-Gyeong, Kwak, Joohwa, Kim, Sun Hye, Lee, Moo Hyun, Lee, Eun Sook, Kang, Han-Sung, Lee, Keun Seok, Park, In Hae, Sim, Sung Hoon, Jeong, Hae Jeong, Kwon, Youngmee, Lee, Dong-Eun, Kim, Seok-Ki, & Lee, Seeyoun. The Sentinel Lymph Node Biopsy Using Indocyanine Green Fluorescence Plus Radioisotope Method Compared With the Radioisotope-Only Method for Breast Cancer Patients After Neoadjuvant Chemotherapy: A Prospective, Randomized, Open-Label, Single-Center Phase 2 Trial. United States. https://doi.org/10.1245/S10434-019-07400-0
Jung, So-Youn, Han, Jai Hong, Park, Soo Jin, Lee, Eun-Gyeong, Kwak, Joohwa, Kim, Sun Hye, Lee, Moo Hyun, Lee, Eun Sook, Kang, Han-Sung, Lee, Keun Seok, Park, In Hae, Sim, Sung Hoon, Jeong, Hae Jeong, Kwon, Youngmee, Lee, Dong-Eun, Kim, Seok-Ki, and Lee, Seeyoun. 2019. "The Sentinel Lymph Node Biopsy Using Indocyanine Green Fluorescence Plus Radioisotope Method Compared With the Radioisotope-Only Method for Breast Cancer Patients After Neoadjuvant Chemotherapy: A Prospective, Randomized, Open-Label, Single-Center Phase 2 Trial". United States. https://doi.org/10.1245/S10434-019-07400-0.
@article{osti_22927646,
title = {The Sentinel Lymph Node Biopsy Using Indocyanine Green Fluorescence Plus Radioisotope Method Compared With the Radioisotope-Only Method for Breast Cancer Patients After Neoadjuvant Chemotherapy: A Prospective, Randomized, Open-Label, Single-Center Phase 2 Trial},
author = {Jung, So-Youn and Han, Jai Hong and Park, Soo Jin and Lee, Eun-Gyeong and Kwak, Joohwa and Kim, Sun Hye and Lee, Moo Hyun and Lee, Eun Sook and Kang, Han-Sung and Lee, Keun Seok and Park, In Hae and Sim, Sung Hoon and Jeong, Hae Jeong and Kwon, Youngmee and Lee, Dong-Eun and Kim, Seok-Ki and Lee, Seeyoun},
abstractNote = {Background: This study aimed to compare the sentinel lymph node (SLN) identification rates for breast cancer patients after neoadjuvant chemotherapy (NAC) between the dual method (DM) of indocyanine green fluorescence (ICG-F) plus a radioisotope (RI) and RI alone. Methods: This randomized study enrolled 130 patients who received NAC for breast cancer and 122 patients who received SLN biopsy (SLNB) using either DM (n = 58) or RI only (n = 64). The study compared the identification rate, number of SLNs, and detection time of SLNB. Results: Among the 122 patients, 113 (92.6%) were clinically node-positive before NAC. The SLN identification rate was 98.3% in the DM group and 93.8% in the RI group (p = 0.14). The DM group and the RI group were similar in the average number of SLNs (2.2 ± 1.13 vs. 1.9 ± 1.33; p = 0.26) and the time to detection of the first SLN (8.7 ± 4.98 vs. 8.3 ± 4.31 min; p = 0.30). In the DM group, transcutaneous lymphatic drainage was visualized by fluorescence imaging for 65.5% (38 of 58) of the patients. The SLN identification rate was 94.7% using ICG-F and 93% using RI (p = 0.79). During and after the operation, no complications, including allergic reactions or skin necrosis, occurred. Conclusions: This study is the first randomized trial to use ICG-F for SLNB in breast cancer patients after NAC. The DM including ICG-F could be a feasible and safe method for SLNB in initially node-positive breast cancer patients with NAC.},
doi = {10.1245/S10434-019-07400-0},
url = {https://www.osti.gov/biblio/22927646}, journal = {Annals of Surgical Oncology (Online)},
issn = {1534-4681},
number = 8,
volume = 26,
place = {United States},
year = {2019},
month = {8}
}