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Title: Indocyanine Green Fluorescence Imaging with Lymphoscintigraphy for Sentinel Node Biopsy in Melanoma: Increasing the Sentinel Lymph Node-Positive Rate

Abstract

Introduction: The goal of this study was to analyze patients who underwent a sentinel lymph node biopsy (SLNB) in melanoma with the combination of radioisotope lymphoscintigraphy and indocyanine green (ICG) fluorescence imaging to compare our true positive (TP) rate, a means to perform immediate analysis of the SLNB, with that of the literature. Methods: Consecutive cutaneous melanoma patients who underwent SLNB with lymphoscintigraphy and ICG-based fluorescence imaging by the senior author (BG) from 2012 to 2018 were prospectively enrolled. The average expected SLN-positive rate per T stage was calculated based on three studies and compared with our SLN-positive rate. Results: Overall, 574 consecutive patients were analyzed. Average Breslow thickness was 1.9 mm. A total of 1754 sentinel nodes were sampled; 1497 were identified by gamma probe signaling and ICG, 241 were identified by gamma probe signaling only, and 16 were identified by ICG only. There were 123 (21.4%) patients with at least one positive SLN; 113 (91.9%) had at least one positive node identified with both gamma probe signaling and ICG, 8 (6.5%) had positive node(s) identified with gamma probe signaling only, and 2 (1.6%) had positive node(s) identified with ICG only. There was an overall 21.4% SLN-positive rate, with 8%more » T1, 18.5% T2, 41.1% T3, and 52.4% T4, which is higher than the predicted rates for each stage. Conclusions: With the largest cohort of patients reported who underwent a melanoma SLNB with lymphoscintigraphy and ICG, we demonstrated that this technique results in higher SLN-positive rates than predicted. Patients are being followed but, given the TP data, knowledge of our results may foster the use of this modality to improve staging and treatment options.« less

Authors:
;  [1];  [2];  [1];  [3];  [1]
  1. Cleveland Clinic Foundation, Department of Plastic and Reconstructive Surgery (United States)
  2. Cleveland Clinic Foundation, Department of Anatomic Pathology (United States)
  3. University of Toledo Medical School (United States)
Publication Date:
OSTI Identifier:
22927564
Resource Type:
Journal Article
Journal Name:
Annals of Surgical Oncology (Online)
Additional Journal Information:
Journal Volume: 26; Journal Issue: 11; Other Information: Copyright (c) 2019 Society of Surgical Oncology; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 1534-4681
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BIOPSY; INDOCYANINE GREEN; LYMPH NODES; MELANOMAS; PATIENTS; RADIOISOTOPES; SCINTISCANNING

Citation Formats

Knackstedt, Rebecca, Couto, Rafael A., Ko, Jennifer, Cakmakoglu, Cagri, Wu, Daisy, and Gastman, Brian. Indocyanine Green Fluorescence Imaging with Lymphoscintigraphy for Sentinel Node Biopsy in Melanoma: Increasing the Sentinel Lymph Node-Positive Rate. United States: N. p., 2019. Web. doi:10.1245/S10434-019-07617-Z.
Knackstedt, Rebecca, Couto, Rafael A., Ko, Jennifer, Cakmakoglu, Cagri, Wu, Daisy, & Gastman, Brian. Indocyanine Green Fluorescence Imaging with Lymphoscintigraphy for Sentinel Node Biopsy in Melanoma: Increasing the Sentinel Lymph Node-Positive Rate. United States. https://doi.org/10.1245/S10434-019-07617-Z
Knackstedt, Rebecca, Couto, Rafael A., Ko, Jennifer, Cakmakoglu, Cagri, Wu, Daisy, and Gastman, Brian. 2019. "Indocyanine Green Fluorescence Imaging with Lymphoscintigraphy for Sentinel Node Biopsy in Melanoma: Increasing the Sentinel Lymph Node-Positive Rate". United States. https://doi.org/10.1245/S10434-019-07617-Z.
@article{osti_22927564,
title = {Indocyanine Green Fluorescence Imaging with Lymphoscintigraphy for Sentinel Node Biopsy in Melanoma: Increasing the Sentinel Lymph Node-Positive Rate},
author = {Knackstedt, Rebecca and Couto, Rafael A. and Ko, Jennifer and Cakmakoglu, Cagri and Wu, Daisy and Gastman, Brian},
abstractNote = {Introduction: The goal of this study was to analyze patients who underwent a sentinel lymph node biopsy (SLNB) in melanoma with the combination of radioisotope lymphoscintigraphy and indocyanine green (ICG) fluorescence imaging to compare our true positive (TP) rate, a means to perform immediate analysis of the SLNB, with that of the literature. Methods: Consecutive cutaneous melanoma patients who underwent SLNB with lymphoscintigraphy and ICG-based fluorescence imaging by the senior author (BG) from 2012 to 2018 were prospectively enrolled. The average expected SLN-positive rate per T stage was calculated based on three studies and compared with our SLN-positive rate. Results: Overall, 574 consecutive patients were analyzed. Average Breslow thickness was 1.9 mm. A total of 1754 sentinel nodes were sampled; 1497 were identified by gamma probe signaling and ICG, 241 were identified by gamma probe signaling only, and 16 were identified by ICG only. There were 123 (21.4%) patients with at least one positive SLN; 113 (91.9%) had at least one positive node identified with both gamma probe signaling and ICG, 8 (6.5%) had positive node(s) identified with gamma probe signaling only, and 2 (1.6%) had positive node(s) identified with ICG only. There was an overall 21.4% SLN-positive rate, with 8% T1, 18.5% T2, 41.1% T3, and 52.4% T4, which is higher than the predicted rates for each stage. Conclusions: With the largest cohort of patients reported who underwent a melanoma SLNB with lymphoscintigraphy and ICG, we demonstrated that this technique results in higher SLN-positive rates than predicted. Patients are being followed but, given the TP data, knowledge of our results may foster the use of this modality to improve staging and treatment options.},
doi = {10.1245/S10434-019-07617-Z},
url = {https://www.osti.gov/biblio/22927564}, journal = {Annals of Surgical Oncology (Online)},
issn = {1534-4681},
number = 11,
volume = 26,
place = {United States},
year = {2019},
month = {10}
}