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Title: Exploration of the Effect of Chitosan and Crosslinking Agent Concentration on the Properties of Dual Responsive Chitosan-g-Poly (N-Isopropylacrylamide) Co-polymeric Particles

Abstract

The objective of the present study was to synthesize and evaluate the effect of change in concentration of chitosan (CS) and N,N-methylenebisacrylamide (MBA)- a cross linking agent, on various properties such as lower critical solution temperature (LCST), zeta potential, particle size and poly dispersity index (PDI) of the synthesized co-polymer. Nine different formulations of chitosan-g-poly (N-isopropylacrylamide) (CS-g-PNIPAAm) co-polymer with varying CS and MBA concentrations were synthesized by a surfactant free dispersion copolymerization method. The synthesized co-polymer was further characterized and confirmed for its structure, morphology, particle size, zeta-potential, thermo and pH responsive properties, in-vitro cyto-compatability and stability studies using various analytical tools. The data confirms the successful synthesis of co-polymer. The increase in the concentrations of CS and MBA during the polymerization of co-polymer, resulted in proportional increase of LCST and zeta potential with decrease in particle size of co-polymeric nanoparticles. pH responsive studies showed that as the pH of the medium increases particle size and zeta potential decreases with increase in LCST of co-polymeric nanoparticles. From the results, it can be inferred that the synthesized co-polymeric nanoparticles exerted thermo and pH responsive properties with biocompatibility. By varying the CS and MBA concentrations in the co-polymer, desired LCST, particle size andmore » zeta potential for co-polymeric nanoparticles can be obtained and thus the synthesized co-polymer may have great potential to be used as a drug carrier (nanoform) with both thermo and pH responsiveness.« less

Authors:
 [1];  [2];  [1]
  1. KLE University’s College of Pharmacy, Department of Pharmaceutics (India)
  2. KLE Society’s College of Pharmacy, Department of Pharmaceutical Chemistry (India)
Publication Date:
OSTI Identifier:
22788254
Resource Type:
Journal Article
Journal Name:
Journal of Polymers and the Environment
Additional Journal Information:
Journal Volume: 26; Journal Issue: 2; Other Information: Copyright (c) 2018 Springer Science+Business Media, LLC, part of Springer Nature; Article Copyright (c) 2017 Springer Science+Business Media New York; http://www.springer-ny.com; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 1566-2543
Country of Publication:
United States
Language:
English
Subject:
36 MATERIALS SCIENCE; AMINO ACIDS; CONCENTRATION RATIO; COPOLYMERIZATION; COPOLYMERS; IN VITRO; MORPHOLOGY; NANOPARTICLES; OLIGOSACCHARIDES; PARTICLE SIZE; PH VALUE; SURFACTANTS; SYNTHESIS

Citation Formats

Patil, Archana S., E-mail: archupharma@gmail.com, Gadad, Anand P., Hiremath, Ravindra D., and Dandagi, Panchakshari M. Exploration of the Effect of Chitosan and Crosslinking Agent Concentration on the Properties of Dual Responsive Chitosan-g-Poly (N-Isopropylacrylamide) Co-polymeric Particles. United States: N. p., 2018. Web. doi:10.1007/S10924-017-0971-Z.
Patil, Archana S., E-mail: archupharma@gmail.com, Gadad, Anand P., Hiremath, Ravindra D., & Dandagi, Panchakshari M. Exploration of the Effect of Chitosan and Crosslinking Agent Concentration on the Properties of Dual Responsive Chitosan-g-Poly (N-Isopropylacrylamide) Co-polymeric Particles. United States. doi:10.1007/S10924-017-0971-Z.
Patil, Archana S., E-mail: archupharma@gmail.com, Gadad, Anand P., Hiremath, Ravindra D., and Dandagi, Panchakshari M. Thu . "Exploration of the Effect of Chitosan and Crosslinking Agent Concentration on the Properties of Dual Responsive Chitosan-g-Poly (N-Isopropylacrylamide) Co-polymeric Particles". United States. doi:10.1007/S10924-017-0971-Z.
@article{osti_22788254,
title = {Exploration of the Effect of Chitosan and Crosslinking Agent Concentration on the Properties of Dual Responsive Chitosan-g-Poly (N-Isopropylacrylamide) Co-polymeric Particles},
author = {Patil, Archana S., E-mail: archupharma@gmail.com and Gadad, Anand P. and Hiremath, Ravindra D. and Dandagi, Panchakshari M.},
abstractNote = {The objective of the present study was to synthesize and evaluate the effect of change in concentration of chitosan (CS) and N,N-methylenebisacrylamide (MBA)- a cross linking agent, on various properties such as lower critical solution temperature (LCST), zeta potential, particle size and poly dispersity index (PDI) of the synthesized co-polymer. Nine different formulations of chitosan-g-poly (N-isopropylacrylamide) (CS-g-PNIPAAm) co-polymer with varying CS and MBA concentrations were synthesized by a surfactant free dispersion copolymerization method. The synthesized co-polymer was further characterized and confirmed for its structure, morphology, particle size, zeta-potential, thermo and pH responsive properties, in-vitro cyto-compatability and stability studies using various analytical tools. The data confirms the successful synthesis of co-polymer. The increase in the concentrations of CS and MBA during the polymerization of co-polymer, resulted in proportional increase of LCST and zeta potential with decrease in particle size of co-polymeric nanoparticles. pH responsive studies showed that as the pH of the medium increases particle size and zeta potential decreases with increase in LCST of co-polymeric nanoparticles. From the results, it can be inferred that the synthesized co-polymeric nanoparticles exerted thermo and pH responsive properties with biocompatibility. By varying the CS and MBA concentrations in the co-polymer, desired LCST, particle size and zeta potential for co-polymeric nanoparticles can be obtained and thus the synthesized co-polymer may have great potential to be used as a drug carrier (nanoform) with both thermo and pH responsiveness.},
doi = {10.1007/S10924-017-0971-Z},
journal = {Journal of Polymers and the Environment},
issn = {1566-2543},
number = 2,
volume = 26,
place = {United States},
year = {2018},
month = {2}
}