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Title: A Hybrid Constant and Oscillatory Field Ion Mobility Analyzer Using Structures for Lossless Ion Manipulations

Abstract

Here we explore the combination of constant and oscillatory fields applied in a single device to affect the continuous separation and filtering of ions based on their mobilities. The device explored allows confining and manipulating ions utilizing a combination of radio frequency (rf), direct current (DC) fields, and traveling waves (TW) in a structures for lossless ion manipulations (SLIM) module. We have investigated theoretically and experimentally a concept for continuous filtering of ions based on their mobilities where ions are mobility separated and selected by passage through two regions, both of which incorporated combined TW and constant fields providing opposing forces on the ions. The SLIM module was composed of two surfaces with mirror-image arrays of electrodes and had two regions where the different TW and opposing DC fields could be applied. The filtering capabilities are determined by the applied DC gradient and the TW parameters, such as speed, amplitude, and the TW sequence (i.e., the duty cycle of the traveling wave). The effects of different parameters on the sensitivity and the ion mobility (IM) resolution of the device have been investigated. By appropriately choosing the DC gradient and TW parameters for the two sections, it is possible to transmitmore » ions of a selected mobility while filtering out others of both higher and lower mobility. The novel device described here provides a basis for the targeted analysis of compounds based upon the continuous selection of ions according to their mobility and without the need for high electric fields or pulsed injection. .« less

Authors:
; ; ; ; ; ;  [1]
  1. Pacific Northwest National Laboratory, Biological Sciences Division (United States)
Publication Date:
OSTI Identifier:
22777006
Resource Type:
Journal Article
Journal Name:
Journal of the American Society for Mass Spectrometry
Additional Journal Information:
Journal Volume: 29; Journal Issue: 2; Conference: 32. Asilomar conference on novel instrumentation in MS and ion mobility, Pacific Grove, CA (United States), 14-18 Oct 2016; Other Information: Copyright (c) 2018 American Society for Mass Spectrometry; http://www.springer-ny.com; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 1044-0305
Country of Publication:
United States
Language:
English
Subject:
46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY; DIRECT CURRENT; ELECTRIC FIELDS; IMAGES; ION MOBILITY; RADIOWAVE RADIATION; RESOLUTION; SENSITIVITY; SURFACES; TRAVELLING WAVES

Citation Formats

Prabhakaran, Aneesh, Hamid, Ahmed M., Garimella, Sandilya V. B., Valenzuela, Blandina R., Ewing, Robert G., Ibrahim, Yehia M., E-mail: yehia.ibrahim@pnnl.gov, and Smith, Richard D., E-mail: rds@pnnl.gov. A Hybrid Constant and Oscillatory Field Ion Mobility Analyzer Using Structures for Lossless Ion Manipulations. United States: N. p., 2018. Web. doi:10.1007/S13361-017-1841-6.
Prabhakaran, Aneesh, Hamid, Ahmed M., Garimella, Sandilya V. B., Valenzuela, Blandina R., Ewing, Robert G., Ibrahim, Yehia M., E-mail: yehia.ibrahim@pnnl.gov, & Smith, Richard D., E-mail: rds@pnnl.gov. A Hybrid Constant and Oscillatory Field Ion Mobility Analyzer Using Structures for Lossless Ion Manipulations. United States. doi:10.1007/S13361-017-1841-6.
Prabhakaran, Aneesh, Hamid, Ahmed M., Garimella, Sandilya V. B., Valenzuela, Blandina R., Ewing, Robert G., Ibrahim, Yehia M., E-mail: yehia.ibrahim@pnnl.gov, and Smith, Richard D., E-mail: rds@pnnl.gov. Thu . "A Hybrid Constant and Oscillatory Field Ion Mobility Analyzer Using Structures for Lossless Ion Manipulations". United States. doi:10.1007/S13361-017-1841-6.
@article{osti_22777006,
title = {A Hybrid Constant and Oscillatory Field Ion Mobility Analyzer Using Structures for Lossless Ion Manipulations},
author = {Prabhakaran, Aneesh and Hamid, Ahmed M. and Garimella, Sandilya V. B. and Valenzuela, Blandina R. and Ewing, Robert G. and Ibrahim, Yehia M., E-mail: yehia.ibrahim@pnnl.gov and Smith, Richard D., E-mail: rds@pnnl.gov},
abstractNote = {Here we explore the combination of constant and oscillatory fields applied in a single device to affect the continuous separation and filtering of ions based on their mobilities. The device explored allows confining and manipulating ions utilizing a combination of radio frequency (rf), direct current (DC) fields, and traveling waves (TW) in a structures for lossless ion manipulations (SLIM) module. We have investigated theoretically and experimentally a concept for continuous filtering of ions based on their mobilities where ions are mobility separated and selected by passage through two regions, both of which incorporated combined TW and constant fields providing opposing forces on the ions. The SLIM module was composed of two surfaces with mirror-image arrays of electrodes and had two regions where the different TW and opposing DC fields could be applied. The filtering capabilities are determined by the applied DC gradient and the TW parameters, such as speed, amplitude, and the TW sequence (i.e., the duty cycle of the traveling wave). The effects of different parameters on the sensitivity and the ion mobility (IM) resolution of the device have been investigated. By appropriately choosing the DC gradient and TW parameters for the two sections, it is possible to transmit ions of a selected mobility while filtering out others of both higher and lower mobility. The novel device described here provides a basis for the targeted analysis of compounds based upon the continuous selection of ions according to their mobility and without the need for high electric fields or pulsed injection. .},
doi = {10.1007/S13361-017-1841-6},
journal = {Journal of the American Society for Mass Spectrometry},
issn = {1044-0305},
number = 2,
volume = 29,
place = {United States},
year = {2018},
month = {2}
}