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Title: Improved Quantitative Dynamic Range of Time-of-Flight Mass Spectrometry by Simultaneously Waveform-Averaging and Ion-Counting Data Acquisition

Abstract

Two different types of data acquisition methods, “averaging mode” and “ion-counting mode”, have been used in a time-of-flight (TOF) mass spectrometry. The most common method is an averaging mode that sums waveform signals obtained from each flight cycle. While it is possible to process many ions arriving at the same TOF in one flight cycle, low-abundance ions are difficult to measure because ion signals are overwhelmed by noises from the detection system. An ion-counting mode is suitable for the detection of such low-concentration ions, but counting loss occurs when two or more ions arrive at the detector within the dead time of the acquisition system. In this study, we introduce a technique that combines two methods to measure target ions with a high concentration difference, i.e., averaging mode and ion-counting mode are used simultaneously for high abundant and trace ions, respectively. By processing waveforms concurrently during data acquisition, one can choose to analyze either or both types of data to achieve a highly quantitative mass spectrum over a wide range of sample concentrations. The result of the argon isotope analysis shows that this method provides a more accurate determination of the isotope ratio compared to averaging mode alone at one-twentiethmore » of the analysis time required by ion-counting alone. .« less

Authors:
 [1]; ; ;  [2];  [1]
  1. Osaka University, Department of Earth and Space Science, Graduate School of Science (Japan)
  2. Osaka University, Project Research Center for Fundamental Sciences, Graduate School of Science (Japan)
Publication Date:
OSTI Identifier:
22776887
Resource Type:
Journal Article
Journal Name:
Journal of the American Society for Mass Spectrometry
Additional Journal Information:
Journal Volume: 29; Journal Issue: 7; Other Information: Copyright (c) 2018 American Society for Mass Spectrometry; http://www.springer-ny.com; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 1044-0305
Country of Publication:
United States
Language:
English
Subject:
46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY; COMPARATIVE EVALUATIONS; CONCENTRATION RATIO; DATA ACQUISITION; DEAD TIME; DETECTION; IONS; ISOTOPE RATIO; MASS SPECTRA; MASS SPECTROSCOPY; NOISE; SIGNALS; TIME-OF-FLIGHT METHOD; WAVE FORMS

Citation Formats

Kawai, Yosuke, Hondo, Toshinobu, Jensen, Kirk R., Toyoda, Michisato, and Terada, Kentaro. Improved Quantitative Dynamic Range of Time-of-Flight Mass Spectrometry by Simultaneously Waveform-Averaging and Ion-Counting Data Acquisition. United States: N. p., 2018. Web. doi:10.1007/S13361-018-1967-1.
Kawai, Yosuke, Hondo, Toshinobu, Jensen, Kirk R., Toyoda, Michisato, & Terada, Kentaro. Improved Quantitative Dynamic Range of Time-of-Flight Mass Spectrometry by Simultaneously Waveform-Averaging and Ion-Counting Data Acquisition. United States. doi:10.1007/S13361-018-1967-1.
Kawai, Yosuke, Hondo, Toshinobu, Jensen, Kirk R., Toyoda, Michisato, and Terada, Kentaro. Sun . "Improved Quantitative Dynamic Range of Time-of-Flight Mass Spectrometry by Simultaneously Waveform-Averaging and Ion-Counting Data Acquisition". United States. doi:10.1007/S13361-018-1967-1.
@article{osti_22776887,
title = {Improved Quantitative Dynamic Range of Time-of-Flight Mass Spectrometry by Simultaneously Waveform-Averaging and Ion-Counting Data Acquisition},
author = {Kawai, Yosuke and Hondo, Toshinobu and Jensen, Kirk R. and Toyoda, Michisato and Terada, Kentaro},
abstractNote = {Two different types of data acquisition methods, “averaging mode” and “ion-counting mode”, have been used in a time-of-flight (TOF) mass spectrometry. The most common method is an averaging mode that sums waveform signals obtained from each flight cycle. While it is possible to process many ions arriving at the same TOF in one flight cycle, low-abundance ions are difficult to measure because ion signals are overwhelmed by noises from the detection system. An ion-counting mode is suitable for the detection of such low-concentration ions, but counting loss occurs when two or more ions arrive at the detector within the dead time of the acquisition system. In this study, we introduce a technique that combines two methods to measure target ions with a high concentration difference, i.e., averaging mode and ion-counting mode are used simultaneously for high abundant and trace ions, respectively. By processing waveforms concurrently during data acquisition, one can choose to analyze either or both types of data to achieve a highly quantitative mass spectrum over a wide range of sample concentrations. The result of the argon isotope analysis shows that this method provides a more accurate determination of the isotope ratio compared to averaging mode alone at one-twentieth of the analysis time required by ion-counting alone. .},
doi = {10.1007/S13361-018-1967-1},
journal = {Journal of the American Society for Mass Spectrometry},
issn = {1044-0305},
number = 7,
volume = 29,
place = {United States},
year = {2018},
month = {7}
}