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Title: Gain Switching for a Detection System to Accommodate a Newly Developed MALDI-Based Quantification Method

Abstract

In matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF), matrix-derived ions are routinely deflected away to avoid problems with ion detection. This, however, limits the use of a quantification method that utilizes the analyte-to-matrix ion abundance ratio. In this work, we will show that it is possible to measure this ratio by a minor instrumental modification of a simple form of MALDI-TOF. This involves detector gain switching. .

Authors:
 [1];  [2];  [1];  [3]
  1. Seoul National University, Department of Chemistry (Korea, Republic of)
  2. Institute for Basic Science (IBS), Center for Nanoparticle Research (Korea, Republic of)
  3. KRIBB, Disease Target Structure Research Center (Korea, Republic of)
Publication Date:
OSTI Identifier:
22776878
Resource Type:
Journal Article
Journal Name:
Journal of the American Society for Mass Spectrometry
Additional Journal Information:
Journal Volume: 28; Journal Issue: 9; Other Information: Copyright (c) 2017 American Society for Mass Spectrometry; http://www.springer-ny.com; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 1044-0305
Country of Publication:
United States
Language:
English
Subject:
46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY; DESORPTION; ION DETECTION; IONIZATION; LASERS; MASS SPECTROSCOPY; TIME-OF-FLIGHT METHOD

Citation Formats

Ahn, Sung Hee, Hyeon, Taeghwan, Kim, Myung Soo, E-mail: myungsoo@snu.ac.kr, and Moon, Jeong Hee, E-mail: jhdal@kribb.re.kr. Gain Switching for a Detection System to Accommodate a Newly Developed MALDI-Based Quantification Method. United States: N. p., 2017. Web. doi:10.1007/S13361-017-1711-2.
Ahn, Sung Hee, Hyeon, Taeghwan, Kim, Myung Soo, E-mail: myungsoo@snu.ac.kr, & Moon, Jeong Hee, E-mail: jhdal@kribb.re.kr. Gain Switching for a Detection System to Accommodate a Newly Developed MALDI-Based Quantification Method. United States. doi:10.1007/S13361-017-1711-2.
Ahn, Sung Hee, Hyeon, Taeghwan, Kim, Myung Soo, E-mail: myungsoo@snu.ac.kr, and Moon, Jeong Hee, E-mail: jhdal@kribb.re.kr. Fri . "Gain Switching for a Detection System to Accommodate a Newly Developed MALDI-Based Quantification Method". United States. doi:10.1007/S13361-017-1711-2.
@article{osti_22776878,
title = {Gain Switching for a Detection System to Accommodate a Newly Developed MALDI-Based Quantification Method},
author = {Ahn, Sung Hee and Hyeon, Taeghwan and Kim, Myung Soo, E-mail: myungsoo@snu.ac.kr and Moon, Jeong Hee, E-mail: jhdal@kribb.re.kr},
abstractNote = {In matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF), matrix-derived ions are routinely deflected away to avoid problems with ion detection. This, however, limits the use of a quantification method that utilizes the analyte-to-matrix ion abundance ratio. In this work, we will show that it is possible to measure this ratio by a minor instrumental modification of a simple form of MALDI-TOF. This involves detector gain switching. .},
doi = {10.1007/S13361-017-1711-2},
journal = {Journal of the American Society for Mass Spectrometry},
issn = {1044-0305},
number = 9,
volume = 28,
place = {United States},
year = {2017},
month = {9}
}