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Title: Dimethyl sulfoxide-induced dehydration of the intermembrane space of dipalmitoylphosphatidylcholine multilamellar vesicles: Neutron and synchrotron diffraction study

Abstract

Small-angle neutron scattering spectra of a polydispersed population of dipalmitoylphosphatidylcholine (DPPC) unilamellar vesicles in heavy water in the presence of dimethyl sulfoxide (DMSO) are analyzed by means of the separated form-factor method. An increase in the mole fraction of DMSO in water from 0 to 15% was shown to lead to an increase in the thickness of the bilayer to the characteristics repeat distances of DPPC multilamellar membranes. This fact is indicative of dehydration of the intermembrane space and a steric contact between adjacent DPPC bilayers at 15% mole fraction of DMSO.

Authors:
;  [1]
  1. Joint Institute for Nuclear Research (Russian Federation)
Publication Date:
OSTI Identifier:
22758342
Resource Type:
Journal Article
Journal Name:
Crystallography Reports
Additional Journal Information:
Journal Volume: 62; Journal Issue: 5; Other Information: Copyright (c) 2017 Pleiades Publishing, Inc.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 1063-7745
Country of Publication:
United States
Language:
English
Subject:
75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND SUPERFLUIDITY; DEHYDRATION; DISTANCE; DMSO; FORM FACTORS; HEAVY WATER; LAYERS; NEUTRON DIFFRACTION; SMALL ANGLE SCATTERING; SPECTRA; THICKNESS

Citation Formats

Kiselev, M. A., E-mail: kiselev@jinr.ru, and Zemlyanaya, E. V., E-mail: elena@jinr.ru. Dimethyl sulfoxide-induced dehydration of the intermembrane space of dipalmitoylphosphatidylcholine multilamellar vesicles: Neutron and synchrotron diffraction study. United States: N. p., 2017. Web. doi:10.1134/S106377451705011X.
Kiselev, M. A., E-mail: kiselev@jinr.ru, & Zemlyanaya, E. V., E-mail: elena@jinr.ru. Dimethyl sulfoxide-induced dehydration of the intermembrane space of dipalmitoylphosphatidylcholine multilamellar vesicles: Neutron and synchrotron diffraction study. United States. doi:10.1134/S106377451705011X.
Kiselev, M. A., E-mail: kiselev@jinr.ru, and Zemlyanaya, E. V., E-mail: elena@jinr.ru. Fri . "Dimethyl sulfoxide-induced dehydration of the intermembrane space of dipalmitoylphosphatidylcholine multilamellar vesicles: Neutron and synchrotron diffraction study". United States. doi:10.1134/S106377451705011X.
@article{osti_22758342,
title = {Dimethyl sulfoxide-induced dehydration of the intermembrane space of dipalmitoylphosphatidylcholine multilamellar vesicles: Neutron and synchrotron diffraction study},
author = {Kiselev, M. A., E-mail: kiselev@jinr.ru and Zemlyanaya, E. V., E-mail: elena@jinr.ru},
abstractNote = {Small-angle neutron scattering spectra of a polydispersed population of dipalmitoylphosphatidylcholine (DPPC) unilamellar vesicles in heavy water in the presence of dimethyl sulfoxide (DMSO) are analyzed by means of the separated form-factor method. An increase in the mole fraction of DMSO in water from 0 to 15% was shown to lead to an increase in the thickness of the bilayer to the characteristics repeat distances of DPPC multilamellar membranes. This fact is indicative of dehydration of the intermembrane space and a steric contact between adjacent DPPC bilayers at 15% mole fraction of DMSO.},
doi = {10.1134/S106377451705011X},
journal = {Crystallography Reports},
issn = {1063-7745},
number = 5,
volume = 62,
place = {United States},
year = {2017},
month = {9}
}