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Title: Synthesis, Crystal Structure, Electrochemical Properties, and Biological Activity of 2-((1H-Benzimidazol-2-yl)methylamino)acetic Acid

Abstract

A water soluble compound, (2-((1H-benzimidazol-2-yl)methylamino)acetic acid, BIGH, has been synthesized and structurally characterized by elemental analysis, IR and UV spectroscopies, {sup 1}H-NMR, thermogravimetric and differential thermal analyses, and single crystal and powder X-ray diffraction. BIGH can act as a flexible planar ligand with three potential coordination sites. It crystallizes in a monoclinic system with the sp. gr. P2{sub 1}/c with the unit cell parameters, a = 9.3764(7) Å, b = 11.5031(8) Å, c = 10.0543(6) Å, and Z = 4. The crystal structure was stabilized through inter-molecular hydrogen bonds. The anti-microbial activity of the compound has been studied against Escherichia coli, Bacillus subtilis, Pseudomonas aeruginosa, and Staphylococcus aureus, which showed a good activity against Bacillus subtilis. Cyclic voltammogram of the compound shows that it is a redox-active molecule.

Authors:
 [1];  [2];  [1]
  1. Jawaharlal Nehru Technological University Hyderabad, Department of Chemistry (India)
  2. University of Hyderabad, School of Chemistry (India)
Publication Date:
OSTI Identifier:
22758217
Resource Type:
Journal Article
Journal Name:
Crystallography Reports
Additional Journal Information:
Journal Volume: 63; Journal Issue: 4; Other Information: Copyright (c) 2018 Pleiades Publishing, Inc.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 1063-7745
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; 60 APPLIED LIFE SCIENCES; ACETIC ACID; BACILLUS SUBTILIS; DIFFERENTIAL THERMAL ANALYSIS; ELECTROCHEMISTRY; ESCHERICHIA COLI; HYDROGEN; HYDROGEN 1; LIGANDS; MOLECULES; MONOCLINIC LATTICES; MONOCRYSTALS; NUCLEAR MAGNETIC RESONANCE; POWDERS; PSEUDOMONAS; SPECTROSCOPY; STAPHYLOCOCCUS; SYNTHESIS; THERMAL GRAVIMETRIC ANALYSIS; WATER; X-RAY DIFFRACTION

Citation Formats

Sabithakala, T., Bhargavi, G., and Venkata Ramana Reddy, Ch., E-mail: vrr9@jntuh.ac.in. Synthesis, Crystal Structure, Electrochemical Properties, and Biological Activity of 2-((1H-Benzimidazol-2-yl)methylamino)acetic Acid. United States: N. p., 2018. Web. doi:10.1134/S1063774518040235.
Sabithakala, T., Bhargavi, G., & Venkata Ramana Reddy, Ch., E-mail: vrr9@jntuh.ac.in. Synthesis, Crystal Structure, Electrochemical Properties, and Biological Activity of 2-((1H-Benzimidazol-2-yl)methylamino)acetic Acid. United States. doi:10.1134/S1063774518040235.
Sabithakala, T., Bhargavi, G., and Venkata Ramana Reddy, Ch., E-mail: vrr9@jntuh.ac.in. Sun . "Synthesis, Crystal Structure, Electrochemical Properties, and Biological Activity of 2-((1H-Benzimidazol-2-yl)methylamino)acetic Acid". United States. doi:10.1134/S1063774518040235.
@article{osti_22758217,
title = {Synthesis, Crystal Structure, Electrochemical Properties, and Biological Activity of 2-((1H-Benzimidazol-2-yl)methylamino)acetic Acid},
author = {Sabithakala, T. and Bhargavi, G. and Venkata Ramana Reddy, Ch., E-mail: vrr9@jntuh.ac.in},
abstractNote = {A water soluble compound, (2-((1H-benzimidazol-2-yl)methylamino)acetic acid, BIGH, has been synthesized and structurally characterized by elemental analysis, IR and UV spectroscopies, {sup 1}H-NMR, thermogravimetric and differential thermal analyses, and single crystal and powder X-ray diffraction. BIGH can act as a flexible planar ligand with three potential coordination sites. It crystallizes in a monoclinic system with the sp. gr. P2{sub 1}/c with the unit cell parameters, a = 9.3764(7) Å, b = 11.5031(8) Å, c = 10.0543(6) Å, and Z = 4. The crystal structure was stabilized through inter-molecular hydrogen bonds. The anti-microbial activity of the compound has been studied against Escherichia coli, Bacillus subtilis, Pseudomonas aeruginosa, and Staphylococcus aureus, which showed a good activity against Bacillus subtilis. Cyclic voltammogram of the compound shows that it is a redox-active molecule.},
doi = {10.1134/S1063774518040235},
journal = {Crystallography Reports},
issn = {1063-7745},
number = 4,
volume = 63,
place = {United States},
year = {2018},
month = {7}
}