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Title: Magnetic Particle Imaging Guided Real-Time Percutaneous Transluminal Angioplasty in a Phantom Model

Abstract

PurposeTo investigate the potential of real-time magnetic particle imaging (MPI) to guide percutaneous transluminal angioplasty (PTA) of vascular stenoses in a phantom model.Materials and MethodsExperiments were conducted on a custom-built MPI scanner. Vascular stenosis phantoms consisted of polyvinyl chloride tubes (inner diameter 8 mm) prepared with a centrally aligned cable tie to form ~ 50% stenoses. MPI angiography for visualization of stenoses was performed using the superparamagnetic iron oxide nanoparticle-based contrast agent Ferucarbotran (10 mmol (Fe)/l). Balloon catheters and guidewires for PTA were visualized using custom-made lacquer markers based on Ferucarbotran. Stenosis dilation (n = 3) was performed by manually inflating the PTA balloon with diluted Ferucarbotran. An online reconstruction framework was implemented for real-time imaging with very short latency time.ResultsVisualization of stenosis phantoms and guidance of interventional instruments in real-time (4 frames/s, ~ 100 ms latency time) was possible using an online reconstruction algorithm. Labeling of guidewires and balloon catheters allowed for precise visualization of instrument positions.ConclusionReal-time MPI-guided PTA in a phantom model is feasible.

Authors:
; ;  [1]; ;  [2];  [1];  [2];  [1]
  1. University Hospital Würzburg, Department of Diagnostic and Interventional Radiology (Germany)
  2. University of Würzburg, Department of Experimental Physics V (Germany)
Publication Date:
OSTI Identifier:
22749909
Resource Type:
Journal Article
Journal Name:
Cardiovascular and Interventional Radiology
Additional Journal Information:
Journal Volume: 41; Journal Issue: 7; Other Information: Copyright (c) 2018 Springer Science+Business Media, LLC, part of Springer Nature and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE); http://www.springer-ny.com; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0174-1551
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BIOMEDICAL RADIOGRAPHY; BLOOD VESSELS; CONTRAST MEDIA; IRON OXIDES; MAXIMUM PERMISSIBLE INTAKE; NANOPARTICLES; PHANTOMS

Citation Formats

Herz, Stefan, Vogel, Patrick, Dietrich, Philipp, Kampf, Thomas, Rückert, Martin A., Kickuth, Ralph, Behr, Volker C., and Bley, Thorsten A. Magnetic Particle Imaging Guided Real-Time Percutaneous Transluminal Angioplasty in a Phantom Model. United States: N. p., 2018. Web. doi:10.1007/S00270-018-1955-7.
Herz, Stefan, Vogel, Patrick, Dietrich, Philipp, Kampf, Thomas, Rückert, Martin A., Kickuth, Ralph, Behr, Volker C., & Bley, Thorsten A. Magnetic Particle Imaging Guided Real-Time Percutaneous Transluminal Angioplasty in a Phantom Model. United States. doi:10.1007/S00270-018-1955-7.
Herz, Stefan, Vogel, Patrick, Dietrich, Philipp, Kampf, Thomas, Rückert, Martin A., Kickuth, Ralph, Behr, Volker C., and Bley, Thorsten A. Sun . "Magnetic Particle Imaging Guided Real-Time Percutaneous Transluminal Angioplasty in a Phantom Model". United States. doi:10.1007/S00270-018-1955-7.
@article{osti_22749909,
title = {Magnetic Particle Imaging Guided Real-Time Percutaneous Transluminal Angioplasty in a Phantom Model},
author = {Herz, Stefan and Vogel, Patrick and Dietrich, Philipp and Kampf, Thomas and Rückert, Martin A. and Kickuth, Ralph and Behr, Volker C. and Bley, Thorsten A.},
abstractNote = {PurposeTo investigate the potential of real-time magnetic particle imaging (MPI) to guide percutaneous transluminal angioplasty (PTA) of vascular stenoses in a phantom model.Materials and MethodsExperiments were conducted on a custom-built MPI scanner. Vascular stenosis phantoms consisted of polyvinyl chloride tubes (inner diameter 8 mm) prepared with a centrally aligned cable tie to form ~ 50% stenoses. MPI angiography for visualization of stenoses was performed using the superparamagnetic iron oxide nanoparticle-based contrast agent Ferucarbotran (10 mmol (Fe)/l). Balloon catheters and guidewires for PTA were visualized using custom-made lacquer markers based on Ferucarbotran. Stenosis dilation (n = 3) was performed by manually inflating the PTA balloon with diluted Ferucarbotran. An online reconstruction framework was implemented for real-time imaging with very short latency time.ResultsVisualization of stenosis phantoms and guidance of interventional instruments in real-time (4 frames/s, ~ 100 ms latency time) was possible using an online reconstruction algorithm. Labeling of guidewires and balloon catheters allowed for precise visualization of instrument positions.ConclusionReal-time MPI-guided PTA in a phantom model is feasible.},
doi = {10.1007/S00270-018-1955-7},
journal = {Cardiovascular and Interventional Radiology},
issn = {0174-1551},
number = 7,
volume = 41,
place = {United States},
year = {2018},
month = {7}
}