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Title: Radiographic Local Tumor Control and Pain Palliation of Sarcoma Metastases within the Musculoskeletal System with Percutaneous Thermal Ablation

Abstract

PurposeTo evaluate the effectiveness of percutaneous image-guided thermal ablation in achieving local tumor control and pain palliation of sarcoma metastases within the musculoskeletal system.Materials and MethodsRetrospective review of 64 sarcoma metastases within the musculoskeletal system in 26 women and 15 men (total = 41) treated with ablation between December 2011 and August 2016 was performed. Mean age of the cohort was 42.9 years ± 16.0 years. Two subgroups were treated: oligometastatic disease (n = 13) and widely metastatic disease (n = 51). A variety of sarcoma histologies were treated with average tumor volume of 42.5 cm{sup 3} (range 0.1–484.7 cm{sup 3}). Pain scores were recorded before and 4 weeks after therapy for 59% (38/64) of treated lesions. Follow-up imaging was evaluated for local control and to monitor sites of untreated disease as an internal control. Fifty-eight percent (37/64) were lost to imaging follow-up at varying time points over a year. Complication rate was 5% (3/64; one minor and two major events).ResultsOne-year local tumor control rates were 70% (19/27) in all patients, 67% (12/18) in the setting of progression of untreated metastases, and 100% (10/10) in the setting of oligometastatic disease. Median pain scores decreased from 8 (interquartile range 5.0–9.0) to 3 (interquartile range 0.1–4.0) 1 month after the procedure (P < 0.001).ConclusionImage-guided percutaneous ablation is anmore » effective option for local tumor control and pain palliation of metastatic sarcomas within the musculoskeletal system. Treatment in the setting of oligometastatic disease offers potential for remission. Level of Evidence: Level 4, Retrospective Review.« less

Authors:
; ; ;  [1];  [2];  [3];  [1]
  1. Mallinckrodt Institute of Radiology (United States)
  2. Washington University School of Medicine in St. Louis (United States)
  3. Keck School of Medicine of USC, Department of Radiology (United States)
Publication Date:
OSTI Identifier:
22749872
Resource Type:
Journal Article
Journal Name:
Cardiovascular and Interventional Radiology
Additional Journal Information:
Journal Volume: 41; Journal Issue: 8; Other Information: Copyright (c) 2018 Springer Science+Business Media, LLC, part of Springer Nature and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE); http://www.springer-ny.com; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0174-1551
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ABLATION; HISTOLOGY; MATERIALS; MEN; PATIENTS; REVIEWS; SARCOMAS; THERAPY; WOMEN

Citation Formats

Vaswani, Devin, Wallace, Adam N., E-mail: adam.n.wallace@gmail.com, Eiswirth, Preston S., E-mail: eiswirthp@wustl.edu, Madaelil, Thomas P., E-mail: madaelil@gmail.com, Chang, Randy O., E-mail: randyochang@wustl.edu, Tomasian, Anderanik, and Jennings, Jack W., E-mail: jackwjennings@wustl.edu. Radiographic Local Tumor Control and Pain Palliation of Sarcoma Metastases within the Musculoskeletal System with Percutaneous Thermal Ablation. United States: N. p., 2018. Web. doi:10.1007/S00270-018-1932-1.
Vaswani, Devin, Wallace, Adam N., E-mail: adam.n.wallace@gmail.com, Eiswirth, Preston S., E-mail: eiswirthp@wustl.edu, Madaelil, Thomas P., E-mail: madaelil@gmail.com, Chang, Randy O., E-mail: randyochang@wustl.edu, Tomasian, Anderanik, & Jennings, Jack W., E-mail: jackwjennings@wustl.edu. Radiographic Local Tumor Control and Pain Palliation of Sarcoma Metastases within the Musculoskeletal System with Percutaneous Thermal Ablation. United States. doi:10.1007/S00270-018-1932-1.
Vaswani, Devin, Wallace, Adam N., E-mail: adam.n.wallace@gmail.com, Eiswirth, Preston S., E-mail: eiswirthp@wustl.edu, Madaelil, Thomas P., E-mail: madaelil@gmail.com, Chang, Randy O., E-mail: randyochang@wustl.edu, Tomasian, Anderanik, and Jennings, Jack W., E-mail: jackwjennings@wustl.edu. Wed . "Radiographic Local Tumor Control and Pain Palliation of Sarcoma Metastases within the Musculoskeletal System with Percutaneous Thermal Ablation". United States. doi:10.1007/S00270-018-1932-1.
@article{osti_22749872,
title = {Radiographic Local Tumor Control and Pain Palliation of Sarcoma Metastases within the Musculoskeletal System with Percutaneous Thermal Ablation},
author = {Vaswani, Devin and Wallace, Adam N., E-mail: adam.n.wallace@gmail.com and Eiswirth, Preston S., E-mail: eiswirthp@wustl.edu and Madaelil, Thomas P., E-mail: madaelil@gmail.com and Chang, Randy O., E-mail: randyochang@wustl.edu and Tomasian, Anderanik and Jennings, Jack W., E-mail: jackwjennings@wustl.edu},
abstractNote = {PurposeTo evaluate the effectiveness of percutaneous image-guided thermal ablation in achieving local tumor control and pain palliation of sarcoma metastases within the musculoskeletal system.Materials and MethodsRetrospective review of 64 sarcoma metastases within the musculoskeletal system in 26 women and 15 men (total = 41) treated with ablation between December 2011 and August 2016 was performed. Mean age of the cohort was 42.9 years ± 16.0 years. Two subgroups were treated: oligometastatic disease (n = 13) and widely metastatic disease (n = 51). A variety of sarcoma histologies were treated with average tumor volume of 42.5 cm{sup 3} (range 0.1–484.7 cm{sup 3}). Pain scores were recorded before and 4 weeks after therapy for 59% (38/64) of treated lesions. Follow-up imaging was evaluated for local control and to monitor sites of untreated disease as an internal control. Fifty-eight percent (37/64) were lost to imaging follow-up at varying time points over a year. Complication rate was 5% (3/64; one minor and two major events).ResultsOne-year local tumor control rates were 70% (19/27) in all patients, 67% (12/18) in the setting of progression of untreated metastases, and 100% (10/10) in the setting of oligometastatic disease. Median pain scores decreased from 8 (interquartile range 5.0–9.0) to 3 (interquartile range 0.1–4.0) 1 month after the procedure (P < 0.001).ConclusionImage-guided percutaneous ablation is an effective option for local tumor control and pain palliation of metastatic sarcomas within the musculoskeletal system. Treatment in the setting of oligometastatic disease offers potential for remission. Level of Evidence: Level 4, Retrospective Review.},
doi = {10.1007/S00270-018-1932-1},
journal = {Cardiovascular and Interventional Radiology},
issn = {0174-1551},
number = 8,
volume = 41,
place = {United States},
year = {2018},
month = {8}
}