skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Assessment of Therapy Response to Transarterial Radioembolization for Liver Metastases by Means of Post-treatment MRI-Based Texture Analysis

Abstract

IntroductionTo determine whether post-treatment magnetic resonance imaging (MRI)-based texture analysis of liver metastases (LM) may be suited predicting therapy response to transarterial radioembolization (TARE) during follow-up.Materials and MethodsThirty-seven patients with LM treated by TARE (mean age 63.4 years) between January 2006 and December 2014 were identified in this retrospective feasibility study. They underwent dynamic contrast-enhanced and hepatocellular phase MRI after TARE (mean 2.2 days). Response was evaluated on follow-up imaging scheduled in intervals of 3 months (median follow-up, 7.3 months) based on response evaluation criteria in solid tumors 1.1 (RECIST 1.1). Results of texture analysis [mean, standard deviation, skewness (s), kurtosis (k), entropy and uniformity] were compared between patients with progressive disease (PD) and patients with stable disease (SD), partial or complete response (PR/CR). Receiver operating characteristics including the area under the curve (AUC) and cutoff values including the sensitivity and specificity were calculated.ResultsAccording to RECIST 1.1, 24 patients (64.9%) had PD, 8 SD (21.6%) and 5 PR (13.5%). MRI-based texture analysis showed an earlier differentiation between patients with and without PD when compared with RECIST 1.1. Median k (2.88 vs. 2.35) in arterial phase MRI and median s (0.48 vs. 0.25) and k (2.85 vs. 2.25) in venous phase MRI were significantly different (p < 0.05).more » The AUC for k derived from arterial phase MRI was 0.73 (cutoff = 2.55, sensitivity = 0.83, specificity = 0.62) (p < 0.05). The AUC for s and k in venous phase MRI was 0.76 (cutoff = 0.35, sensitivity = 0.71, specificity = 0.85) (p > 0.05) and 0.83 (cutoff = 2.50, sensitivity = 0.75, specificity = 0.85) (p < 0.05).ConclusionThis study indicates the potential of MRI-based texture analysis at arterial and venous phase MRI for the early prediction of PD after TARE. Level of Evidence: IV.« less

Authors:
 [1];  [2];  [3]
  1. University of Cologne, Department of Radiology (Germany)
  2. Klinikum Karlsruhe, Academic Teaching Hospital of the University of Freiburg, Institute of Diagnostic and Interventional Radiology (Germany)
  3. Marburg University Hospital, Philipps-University, Department of Diagnostic and Interventional Radiology (Germany)
Publication Date:
OSTI Identifier:
22749782
Resource Type:
Journal Article
Journal Name:
Cardiovascular and Interventional Radiology
Additional Journal Information:
Journal Volume: 41; Journal Issue: 10; Other Information: Copyright (c) 2018 Springer Science+Business Media, LLC, part of Springer Nature and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE); http://www.springer-ny.com; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0174-1551
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; FEASIBILITY STUDIES; LIVER; NMR IMAGING; PATIENTS; RADIOEMBOLIZATION; RADIOSENSITIVITY; SPECIFICITY; TEXTURE

Citation Formats

Reimer, Robert P., E-mail: robert.reimer@uk-koeln.de, Reimer, Peter, and Mahnken, Andreas H. Assessment of Therapy Response to Transarterial Radioembolization for Liver Metastases by Means of Post-treatment MRI-Based Texture Analysis. United States: N. p., 2018. Web. doi:10.1007/S00270-018-2004-2.
Reimer, Robert P., E-mail: robert.reimer@uk-koeln.de, Reimer, Peter, & Mahnken, Andreas H. Assessment of Therapy Response to Transarterial Radioembolization for Liver Metastases by Means of Post-treatment MRI-Based Texture Analysis. United States. doi:10.1007/S00270-018-2004-2.
Reimer, Robert P., E-mail: robert.reimer@uk-koeln.de, Reimer, Peter, and Mahnken, Andreas H. Mon . "Assessment of Therapy Response to Transarterial Radioembolization for Liver Metastases by Means of Post-treatment MRI-Based Texture Analysis". United States. doi:10.1007/S00270-018-2004-2.
@article{osti_22749782,
title = {Assessment of Therapy Response to Transarterial Radioembolization for Liver Metastases by Means of Post-treatment MRI-Based Texture Analysis},
author = {Reimer, Robert P., E-mail: robert.reimer@uk-koeln.de and Reimer, Peter and Mahnken, Andreas H.},
abstractNote = {IntroductionTo determine whether post-treatment magnetic resonance imaging (MRI)-based texture analysis of liver metastases (LM) may be suited predicting therapy response to transarterial radioembolization (TARE) during follow-up.Materials and MethodsThirty-seven patients with LM treated by TARE (mean age 63.4 years) between January 2006 and December 2014 were identified in this retrospective feasibility study. They underwent dynamic contrast-enhanced and hepatocellular phase MRI after TARE (mean 2.2 days). Response was evaluated on follow-up imaging scheduled in intervals of 3 months (median follow-up, 7.3 months) based on response evaluation criteria in solid tumors 1.1 (RECIST 1.1). Results of texture analysis [mean, standard deviation, skewness (s), kurtosis (k), entropy and uniformity] were compared between patients with progressive disease (PD) and patients with stable disease (SD), partial or complete response (PR/CR). Receiver operating characteristics including the area under the curve (AUC) and cutoff values including the sensitivity and specificity were calculated.ResultsAccording to RECIST 1.1, 24 patients (64.9%) had PD, 8 SD (21.6%) and 5 PR (13.5%). MRI-based texture analysis showed an earlier differentiation between patients with and without PD when compared with RECIST 1.1. Median k (2.88 vs. 2.35) in arterial phase MRI and median s (0.48 vs. 0.25) and k (2.85 vs. 2.25) in venous phase MRI were significantly different (p < 0.05). The AUC for k derived from arterial phase MRI was 0.73 (cutoff = 2.55, sensitivity = 0.83, specificity = 0.62) (p < 0.05). The AUC for s and k in venous phase MRI was 0.76 (cutoff = 0.35, sensitivity = 0.71, specificity = 0.85) (p > 0.05) and 0.83 (cutoff = 2.50, sensitivity = 0.75, specificity = 0.85) (p < 0.05).ConclusionThis study indicates the potential of MRI-based texture analysis at arterial and venous phase MRI for the early prediction of PD after TARE. Level of Evidence: IV.},
doi = {10.1007/S00270-018-2004-2},
journal = {Cardiovascular and Interventional Radiology},
issn = {0174-1551},
number = 10,
volume = 41,
place = {United States},
year = {2018},
month = {10}
}