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Title: Hydrophilic Stent Coating Inhibits Platelet Adhesion on Stent Surfaces: Initial Results In Vitro

Abstract

BackgroundEndovascular stents and flow diverter stents (FDS) have revolutionized the treatment of intradural aneurysms; however, the need for dual anti-platelet treatment (DAPT) limits their use and can cause additional issues. Therefore, there is a need to develop stent coatings that negate the need for DAPT.MethodsTwo different hydrophilic polymer coatings (HPC-I and HPC-II) were used to coat small nickel titanium plates to initially test the hydrophilic properties of these coatings when applied to nickel titanium. The plates were subsequently incubated with non-medicated whole blood from healthy volunteers for 10 min and stained with a CD61 immunofluorescent antibody that allows detection of adherent platelets. The coatings were applied to FDS wires and were again incubated with non-medicated whole blood from the same volunteers. Scanning electron microscopy was used to detect adherent platelets on the wire surface.ResultsThe HPC-II coating (1.12 ± 0.4%) showed a significantly lower CD61 +ve cell count (p ≤ 0.001) compared to both uncoated NiTi plates (48.61 ± 7.3%) and those with the HPC-I coating (mean 40.19 ± 8.9%). Minimal adherent platelets were seen on the FDS nickel titanium wires coated with the HPC-II compared to uncoated FDS under electron microscopy.ConclusionThere is a significant decrease in the number of adherent CD61 +ve platelets on nickel titanium surfaces coated with themore » HPC-II coating compared to uncoated surfaces. The coating can be successfully applied to the wires of flow diverters. The results of this study are promising with regard to the development of new anti-thrombogenic endovascular devices.« less

Authors:
 [1];  [2]; ;  [3];  [4]; ;  [1];  [2]
  1. phenox GmbH (Germany)
  2. Klinikum Stuttgart, Neuroradiologische Klinik, Neurozentrum (Germany)
  3. Medizinische Fakultät der Ruhr-Universität Bochum, Abteilung für Experimentelle Pneumologie (Germany)
  4. Complejo Hospitalario Universitario Granada (Spain)
Publication Date:
OSTI Identifier:
22749737
Resource Type:
Journal Article
Journal Name:
Cardiovascular and Interventional Radiology
Additional Journal Information:
Journal Volume: 41; Journal Issue: 11; Other Information: Copyright (c) 2018 Springer Science+Business Media, LLC, part of Springer Nature and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE); Article Copyright (c) 2018 The Author(s); http://www.springer-ny.com; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0174-1551
Country of Publication:
United States
Language:
English
Subject:
36 MATERIALS SCIENCE; APPLIANCES; COATINGS; FLUORINE COMPOUNDS; IN VITRO; NICKEL; PLATES; SCANNING ELECTRON MICROSCOPY; TITANIUM; WIRES

Citation Formats

Lenz-Habijan, Tim, Bhogal, P., Peters, Marcus, Bufe, Albrecht, Martinez Moreno, Rosa, Bannewitz, Catrin, Monstadt, Hermann, and Henkes, Hans. Hydrophilic Stent Coating Inhibits Platelet Adhesion on Stent Surfaces: Initial Results In Vitro. United States: N. p., 2018. Web. doi:10.1007/S00270-018-2036-7.
Lenz-Habijan, Tim, Bhogal, P., Peters, Marcus, Bufe, Albrecht, Martinez Moreno, Rosa, Bannewitz, Catrin, Monstadt, Hermann, & Henkes, Hans. Hydrophilic Stent Coating Inhibits Platelet Adhesion on Stent Surfaces: Initial Results In Vitro. United States. doi:10.1007/S00270-018-2036-7.
Lenz-Habijan, Tim, Bhogal, P., Peters, Marcus, Bufe, Albrecht, Martinez Moreno, Rosa, Bannewitz, Catrin, Monstadt, Hermann, and Henkes, Hans. Thu . "Hydrophilic Stent Coating Inhibits Platelet Adhesion on Stent Surfaces: Initial Results In Vitro". United States. doi:10.1007/S00270-018-2036-7.
@article{osti_22749737,
title = {Hydrophilic Stent Coating Inhibits Platelet Adhesion on Stent Surfaces: Initial Results In Vitro},
author = {Lenz-Habijan, Tim and Bhogal, P. and Peters, Marcus and Bufe, Albrecht and Martinez Moreno, Rosa and Bannewitz, Catrin and Monstadt, Hermann and Henkes, Hans},
abstractNote = {BackgroundEndovascular stents and flow diverter stents (FDS) have revolutionized the treatment of intradural aneurysms; however, the need for dual anti-platelet treatment (DAPT) limits their use and can cause additional issues. Therefore, there is a need to develop stent coatings that negate the need for DAPT.MethodsTwo different hydrophilic polymer coatings (HPC-I and HPC-II) were used to coat small nickel titanium plates to initially test the hydrophilic properties of these coatings when applied to nickel titanium. The plates were subsequently incubated with non-medicated whole blood from healthy volunteers for 10 min and stained with a CD61 immunofluorescent antibody that allows detection of adherent platelets. The coatings were applied to FDS wires and were again incubated with non-medicated whole blood from the same volunteers. Scanning electron microscopy was used to detect adherent platelets on the wire surface.ResultsThe HPC-II coating (1.12 ± 0.4%) showed a significantly lower CD61 +ve cell count (p ≤ 0.001) compared to both uncoated NiTi plates (48.61 ± 7.3%) and those with the HPC-I coating (mean 40.19 ± 8.9%). Minimal adherent platelets were seen on the FDS nickel titanium wires coated with the HPC-II compared to uncoated FDS under electron microscopy.ConclusionThere is a significant decrease in the number of adherent CD61 +ve platelets on nickel titanium surfaces coated with the HPC-II coating compared to uncoated surfaces. The coating can be successfully applied to the wires of flow diverters. The results of this study are promising with regard to the development of new anti-thrombogenic endovascular devices.},
doi = {10.1007/S00270-018-2036-7},
journal = {Cardiovascular and Interventional Radiology},
issn = {0174-1551},
number = 11,
volume = 41,
place = {United States},
year = {2018},
month = {11}
}