A nanoscale Zr-based fluorescent metal-organic framework for selective and sensitive detection of hydrogen sulfide
Hydrogen sulfide (H{sub 2}S) has been commonly viewed as a gas signaling molecule in various physiological and pathological processes. However, the highly efficient H{sub 2}S detection still remains challenging. Herein, we designed a new robust nano metal-organic framework (MOF) UiO-66-CH=CH{sub 2} as a fluorescent probe for rapid, sensitive and selective detection of biological H{sub 2}S. UiO-66-CH=CH{sub 2} was prepared by heating ZrCl{sub 4} and 2-vinylterephthalic acid via a simple method. UiO-66-CH=CH{sub 2} displayed fluorescence quenching to H{sub 2}S and kept excellent selectivity in the presence of biological relevant analytes especially the cysteine and glutathione. This MOF-based probe also exhibited fast response (10 s) and high sensitivity with a detection limit of 6.46 μM which was within the concentration range of biological H{sub 2}S in living system. Moreover, this constructed MOF featured water-stability, nanoscale (20–30 nm) and low toxicity, which made it a promising candidate for biological H{sub 2}S sensing. - Graphical abstract: A nanoscale Zr-based fluorescent metal-organic framework was synthesized for selective and sensitive biological detection of hydrogen sulfide. Display Omitted - Highlights: • We designed a new metal-organic framework UiO-66-CH=CH{sub 2} for biological H{sub 2}S sensing. • The responsive time was 10 s and the detection limit was 6.46 μM. • This probe has anti-interference especially from cysteine and glutathione. • This biological H{sub 2}S probe features low cytotoxicity, water-stability and nanoscale.
- OSTI ID:
- 22742055
- Journal Information:
- Journal of Solid State Chemistry, Vol. 255; Other Information: Copyright (c) 2017 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); ISSN 0022-4596
- Country of Publication:
- United States
- Language:
- English
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