Photodynamic effect of radiation with the wavelength 405 nm on the cells of microorganisms sensitised by metalloporphyrin compounds

Journal Article · Thu Jun 30 00:00:00 EDT 2016 · Quantum Electronics (Woodbury, N.Y.)

DOI:https://doi.org/10.1070/QEL16110· OSTI ID:22724609

Korchenova, M V; Tuchina, E S; Shvayko, V Y ^[1]; Gulkhandanyan, A G; Zakoyan, A A; Gulkhandanyan, G V ^[2]; Kazaryan, R K ^[3]; Dzhagarov, B M ^[4]; Tuchin, V V ^[5]

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1. N.G. Chernyshevsky National Research Saratov State University, Saratov (Russian Federation)
2. H.Kh. Buniatian Institute of Biochemistry, National Academy of Sciences of Armenia, Yerevan (Armenia)
3. Yerevan State Medical University after Mkhitar Heratsi, Yerevan (Armenia)
4. B.I. Stepanov Institute of Physics, National Academy of Sciences of Belarus, Minsk (Belarus)
5. Institute of Precision Mechanics and Control, Russian Academy of Sciences, Saratov (Russian Federation)

We have studied the photodynamic activity of photosensitisers based on metalloporphyrins. New metalloporphyrin compounds are synthesised and characterised, the quantum yields of the singlet oxygen formation are analysed. It is shown that when the photodynamic effect is implemented using the metalloporphyrins with Zn ions and butyl radical in the 3rd and 4th positions of the pyridine ring, the number of opportunistic bacteria, such as Staphylococcus aureus (antibiotic-sensitives and antibiotic-resistant strains), Staphylococcus simulans and Escherichia coli is efficiently reduced by 90% – 99%. (laser biophotonics)

• OSTI ID: 22724609
• Journal Information: Quantum Electronics (Woodbury, N.Y.), Vol. 46, Issue 6; Other Information: Country of input: International Atomic Energy Agency (IAEA); ISSN 1063-7818
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC
ORGANIC
PHYSICAL AND ANALYTICAL CHEMISTRY
ANTIBIOTICS
BIOLOGICAL RADIATION EFFECTS
BUTYL RADICALS
ESCHERICHIA COLI
OXYGEN
PHOTOSENSITIVITY
PORPHYRINS
PYRIDINE
STAPHYLOCOCCUS
SYNTHESIS
WAVELENGTHS
ZINC IONS