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Title: Toward Personalized Dosimetry with {sup 32}P Microparticle Therapy for Advanced Pancreatic Cancer

Abstract

Purpose: To develop a Monte Carlo model for patient-specific dosimetry of {sup 32}P microparticle localized internal radionuclide therapy for advanced pancreatic cancer. Methods and Materials: Spherical tumor geometries and a pancreatic phantom were modeled, as well as different 3-dimensional non-uniform clinical pancreatic geometries based on patient-specific ultrasound images. The dosimetry simulations modeled the dose distribution due to the energy spectrum of emitted beta particles. Results: The average dose for small (3-cm diameter) and large (6-cm diameter) spherical tumors was 111 Gy (for 7.6 MBq administered activity) and 128 Gy (for 58 MBq), respectively. For the clinical 3-dimensional geometries, on the basis of patient data, the mean doses delivered to the tumor were calculated to be in the range 102 to 113 Gy, with negligible dose to the pancreas for the smallest tumor volumes. The calculated dose distributions are highly non-uniform. For the largest tumor studied, the pancreas received approximately 6% of the tumor dose (5.7 Gy). Importantly, we found that because the smallest tumor studied exhibited the most dynamic changes in volume in response to the treatment, the dose to tumor and pancreas is significantly underestimated if a static tumor volume is assumed. Conclusions: These results demonstrate the dosimetry of {sup 32}P microparticle localizedmore » internal radionuclide therapy for pancreatic cancer and the possibility of developing personalized treatment strategies. The results also highlight the importance of considering the effects of non-uniform dose distributions and dynamic change of tumor mass during treatment on the dosimetry of the tumor and critical organs.« less

Authors:
 [1]; ;  [2];  [1]
  1. Institute of Medical Physics, School of Physics, The University of Sydney, Sydney, New South Wales (Australia)
  2. OncoSil Medical, Sydney, New South Wales (Australia)
Publication Date:
OSTI Identifier:
22723048
Resource Type:
Journal Article
Journal Name:
International Journal of Radiation Oncology, Biology and Physics
Additional Journal Information:
Journal Volume: 99; Journal Issue: 4; Other Information: Copyright (c) 2017 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0360-3016
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; DOSIMETRY; GY RANGE; MONTE CARLO METHOD; NEOPLASMS; PANCREAS; PHOSPHORUS 32; RADIATION DOSE DISTRIBUTIONS; RADIATION DOSES; SIMULATION

Citation Formats

Gholami, Yaser Hadi, Wilson, Nicole, James, David, and Kuncic, Zdenka. Toward Personalized Dosimetry with {sup 32}P Microparticle Therapy for Advanced Pancreatic Cancer. United States: N. p., 2017. Web. doi:10.1016/J.IJROBP.2017.07.031.
Gholami, Yaser Hadi, Wilson, Nicole, James, David, & Kuncic, Zdenka. Toward Personalized Dosimetry with {sup 32}P Microparticle Therapy for Advanced Pancreatic Cancer. United States. doi:10.1016/J.IJROBP.2017.07.031.
Gholami, Yaser Hadi, Wilson, Nicole, James, David, and Kuncic, Zdenka. Wed . "Toward Personalized Dosimetry with {sup 32}P Microparticle Therapy for Advanced Pancreatic Cancer". United States. doi:10.1016/J.IJROBP.2017.07.031.
@article{osti_22723048,
title = {Toward Personalized Dosimetry with {sup 32}P Microparticle Therapy for Advanced Pancreatic Cancer},
author = {Gholami, Yaser Hadi and Wilson, Nicole and James, David and Kuncic, Zdenka},
abstractNote = {Purpose: To develop a Monte Carlo model for patient-specific dosimetry of {sup 32}P microparticle localized internal radionuclide therapy for advanced pancreatic cancer. Methods and Materials: Spherical tumor geometries and a pancreatic phantom were modeled, as well as different 3-dimensional non-uniform clinical pancreatic geometries based on patient-specific ultrasound images. The dosimetry simulations modeled the dose distribution due to the energy spectrum of emitted beta particles. Results: The average dose for small (3-cm diameter) and large (6-cm diameter) spherical tumors was 111 Gy (for 7.6 MBq administered activity) and 128 Gy (for 58 MBq), respectively. For the clinical 3-dimensional geometries, on the basis of patient data, the mean doses delivered to the tumor were calculated to be in the range 102 to 113 Gy, with negligible dose to the pancreas for the smallest tumor volumes. The calculated dose distributions are highly non-uniform. For the largest tumor studied, the pancreas received approximately 6% of the tumor dose (5.7 Gy). Importantly, we found that because the smallest tumor studied exhibited the most dynamic changes in volume in response to the treatment, the dose to tumor and pancreas is significantly underestimated if a static tumor volume is assumed. Conclusions: These results demonstrate the dosimetry of {sup 32}P microparticle localized internal radionuclide therapy for pancreatic cancer and the possibility of developing personalized treatment strategies. The results also highlight the importance of considering the effects of non-uniform dose distributions and dynamic change of tumor mass during treatment on the dosimetry of the tumor and critical organs.},
doi = {10.1016/J.IJROBP.2017.07.031},
journal = {International Journal of Radiation Oncology, Biology and Physics},
issn = {0360-3016},
number = 4,
volume = 99,
place = {United States},
year = {2017},
month = {11}
}