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Title: Prompt Gamma Imaging for In Vivo Range Verification of Pencil Beam Scanning Proton Therapy

Abstract

Purpose: To report the first clinical results and value assessment of prompt gamma imaging for in vivo proton range verification in pencil beam scanning mode. Methods and Materials: A stand-alone, trolley-mounted, prototype prompt gamma camera utilizing a knife-edge slit collimator design was used to record the prompt gamma signal emitted along the proton tracks during delivery of proton therapy for a brain cancer patient. The recorded prompt gamma depth detection profiles of individual pencil beam spots were compared with the expected profiles simulated from the treatment plan. Results: In 6 treatment fractions recorded over 3 weeks, the mean (± standard deviation) range shifts aggregated over all spots in 9 energy layers were −0.8 ± 1.3 mm for the lateral field, 1.7 ± 0.7 mm for the right-superior-oblique field, and −0.4 ± 0.9 mm for the vertex field. Conclusions: This study demonstrates the feasibility and illustrates the distinctive benefits of prompt gamma imaging in pencil beam scanning treatment mode. Accuracy in range verification was found in this first clinical case to be better than the range uncertainty margin applied in the treatment plan. These first results lay the foundation for additional work toward tighter integration of the system for in vivo proton range verification and quantification of range uncertainties.

Authors:
 [1]; ; ; ; ;  [2]; ; ; ;  [1];  [2];  [1];  [3]; ;  [1];  [1]
  1. Department of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania (United States)
  2. Advanced Technology Group, Ion Beam Applications SA, Louvain-la-Neuve (Belgium)
  3. Department of Radiation Oncology, University of California, San Francisco, California (United States)
Publication Date:
OSTI Identifier:
22723011
Resource Type:
Journal Article
Journal Name:
International Journal of Radiation Oncology, Biology and Physics
Additional Journal Information:
Journal Volume: 99; Journal Issue: 1; Other Information: Copyright (c) 2017 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0360-3016
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; IN VIVO; PROTON BEAMS; RADIOTHERAPY; VERIFICATION

Citation Formats

Xie, Yunhe, Bentefour, El Hassane, Janssens, Guillaume, Smeets, Julien, Vander Stappen, François, Hotoiu, Lucian, Yin, Lingshu, Dolney, Derek, Avery, Stephen, O'Grady, Fionnbarr, Prieels, Damien, McDonough, James, Solberg, Timothy D., Lustig, Robert A., Lin, Alexander, and Teo, Boon-Keng K., E-mail: Kevin.Teo@uphs.upenn.edu. Prompt Gamma Imaging for In Vivo Range Verification of Pencil Beam Scanning Proton Therapy. United States: N. p., 2017. Web. doi:10.1016/J.IJROBP.2017.04.027.
Xie, Yunhe, Bentefour, El Hassane, Janssens, Guillaume, Smeets, Julien, Vander Stappen, François, Hotoiu, Lucian, Yin, Lingshu, Dolney, Derek, Avery, Stephen, O'Grady, Fionnbarr, Prieels, Damien, McDonough, James, Solberg, Timothy D., Lustig, Robert A., Lin, Alexander, & Teo, Boon-Keng K., E-mail: Kevin.Teo@uphs.upenn.edu. Prompt Gamma Imaging for In Vivo Range Verification of Pencil Beam Scanning Proton Therapy. United States. doi:10.1016/J.IJROBP.2017.04.027.
Xie, Yunhe, Bentefour, El Hassane, Janssens, Guillaume, Smeets, Julien, Vander Stappen, François, Hotoiu, Lucian, Yin, Lingshu, Dolney, Derek, Avery, Stephen, O'Grady, Fionnbarr, Prieels, Damien, McDonough, James, Solberg, Timothy D., Lustig, Robert A., Lin, Alexander, and Teo, Boon-Keng K., E-mail: Kevin.Teo@uphs.upenn.edu. Fri . "Prompt Gamma Imaging for In Vivo Range Verification of Pencil Beam Scanning Proton Therapy". United States. doi:10.1016/J.IJROBP.2017.04.027.
@article{osti_22723011,
title = {Prompt Gamma Imaging for In Vivo Range Verification of Pencil Beam Scanning Proton Therapy},
author = {Xie, Yunhe and Bentefour, El Hassane and Janssens, Guillaume and Smeets, Julien and Vander Stappen, François and Hotoiu, Lucian and Yin, Lingshu and Dolney, Derek and Avery, Stephen and O'Grady, Fionnbarr and Prieels, Damien and McDonough, James and Solberg, Timothy D. and Lustig, Robert A. and Lin, Alexander and Teo, Boon-Keng K., E-mail: Kevin.Teo@uphs.upenn.edu},
abstractNote = {Purpose: To report the first clinical results and value assessment of prompt gamma imaging for in vivo proton range verification in pencil beam scanning mode. Methods and Materials: A stand-alone, trolley-mounted, prototype prompt gamma camera utilizing a knife-edge slit collimator design was used to record the prompt gamma signal emitted along the proton tracks during delivery of proton therapy for a brain cancer patient. The recorded prompt gamma depth detection profiles of individual pencil beam spots were compared with the expected profiles simulated from the treatment plan. Results: In 6 treatment fractions recorded over 3 weeks, the mean (± standard deviation) range shifts aggregated over all spots in 9 energy layers were −0.8 ± 1.3 mm for the lateral field, 1.7 ± 0.7 mm for the right-superior-oblique field, and −0.4 ± 0.9 mm for the vertex field. Conclusions: This study demonstrates the feasibility and illustrates the distinctive benefits of prompt gamma imaging in pencil beam scanning treatment mode. Accuracy in range verification was found in this first clinical case to be better than the range uncertainty margin applied in the treatment plan. These first results lay the foundation for additional work toward tighter integration of the system for in vivo proton range verification and quantification of range uncertainties.},
doi = {10.1016/J.IJROBP.2017.04.027},
journal = {International Journal of Radiation Oncology, Biology and Physics},
issn = {0360-3016},
number = 1,
volume = 99,
place = {United States},
year = {2017},
month = {9}
}