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Title: Comparative health effects in mice of Libby amphibole asbestos and a fibrous amphibole from Arizona

Abstract

This project developed from studies demonstrating that Libby Amphibole Asbestos (LAA) causes a non-typical set of health outcomes not generally reported for asbestos, including systemic autoimmunity and an unusual and devastating lamellar pleural thickening that progresses to severe pulmonary dysfunction and death. Further, mineral fiber mixtures with some similarities to LAA have recently been discovered in southern Nevada and northwestern Arizona, where the material exists in extensive recreational areas and is present in yards, roads, parking lots and school yards. The objective was to compare the health outcomes in mice exposed to either LAA or the fibrous amphiboles collected in Arizona at the Lake Mead National Recreational Area at very low doses to represent environmental exposures. In this study, the fibrous amphibole asbestos sample from Arizona (AzA) is composed of winchite (69%), actinolite (22%), and non-amphibole minerals (9%) and has a mean aspect ratio of 16.7 ± 0.9. Fibrous amphibole asbestos from Libby (LAA) is composed of winchite (70%), richterite (9%), tremolite (5%), and non-amphibole minerals (16%) with a mean aspect ratio of 8.4 ± 0.7. C57BL/6 mice were exposed by oropharyngeal aspiration to fiber suspensions at a very low dose of 3 μg/mouse. After seven months, both LAA- andmore » AzA-exposed mice had indices of chronic immune dysfunction related to a T{sub H}17 cytokine profile, with B cell activation, autoantibody production and proteinuria, suggesting kidney involvement. In addition, both exposures led to significant lung and pleural fibrosis. These data suggest that there is risk of pulmonary disease and autoimmune outcomes with environmental exposure to amphibole asbestos, and that this is not limited to Libby, Montana. - Highlights: • Health effects of Arizona versus Libby amphibole asbestos were comparable in mice. • Both fibers led to immune changes consistent with autoimmune dysfunction. • Both fibers caused significant increases in interstitial and pleural fibrosis. • Novel sources of asbestos could pose health risks even at low exposure levels.« less

Authors:
 [1];  [2];  [2]; ; ;  [1];  [1]
  1. Department of Microbiology and Immunology, Montana State University, Bozeman, MT 59717 (United States)
  2. Department of Geoscience, University of Nevada Las Vegas, Las Vegas, NV 89154 (United States)
Publication Date:
OSTI Identifier:
22722943
Resource Type:
Journal Article
Journal Name:
Toxicology and Applied Pharmacology
Additional Journal Information:
Journal Volume: 334; Other Information: Copyright (c) 2017 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0041-008X
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; AMPHIBOLE; ARIZONA; ASBESTOS; ASPECT RATIO; EDUCATIONAL FACILITIES; ENVIRONMENTAL EXPOSURE; FIBERS; HEALTH HAZARDS; MICE; RECREATIONAL AREAS

Citation Formats

Pfau, Jean C., E-mail: jean.pfau@montana.edu, Buck, Brenda, Metcalf, Rodney V., E-mail: metcalfr@unlv.nevada.edu, Kaupish, Zoie, Stair, Caleb, Rodriguez, Maria, and Keil, Deborah E., E-mail: Deborah.keil@montana.edu. Comparative health effects in mice of Libby amphibole asbestos and a fibrous amphibole from Arizona. United States: N. p., 2017. Web. doi:10.1016/J.TAAP.2017.08.022.
Pfau, Jean C., E-mail: jean.pfau@montana.edu, Buck, Brenda, Metcalf, Rodney V., E-mail: metcalfr@unlv.nevada.edu, Kaupish, Zoie, Stair, Caleb, Rodriguez, Maria, & Keil, Deborah E., E-mail: Deborah.keil@montana.edu. Comparative health effects in mice of Libby amphibole asbestos and a fibrous amphibole from Arizona. United States. doi:10.1016/J.TAAP.2017.08.022.
Pfau, Jean C., E-mail: jean.pfau@montana.edu, Buck, Brenda, Metcalf, Rodney V., E-mail: metcalfr@unlv.nevada.edu, Kaupish, Zoie, Stair, Caleb, Rodriguez, Maria, and Keil, Deborah E., E-mail: Deborah.keil@montana.edu. Wed . "Comparative health effects in mice of Libby amphibole asbestos and a fibrous amphibole from Arizona". United States. doi:10.1016/J.TAAP.2017.08.022.
@article{osti_22722943,
title = {Comparative health effects in mice of Libby amphibole asbestos and a fibrous amphibole from Arizona},
author = {Pfau, Jean C., E-mail: jean.pfau@montana.edu and Buck, Brenda and Metcalf, Rodney V., E-mail: metcalfr@unlv.nevada.edu and Kaupish, Zoie and Stair, Caleb and Rodriguez, Maria and Keil, Deborah E., E-mail: Deborah.keil@montana.edu},
abstractNote = {This project developed from studies demonstrating that Libby Amphibole Asbestos (LAA) causes a non-typical set of health outcomes not generally reported for asbestos, including systemic autoimmunity and an unusual and devastating lamellar pleural thickening that progresses to severe pulmonary dysfunction and death. Further, mineral fiber mixtures with some similarities to LAA have recently been discovered in southern Nevada and northwestern Arizona, where the material exists in extensive recreational areas and is present in yards, roads, parking lots and school yards. The objective was to compare the health outcomes in mice exposed to either LAA or the fibrous amphiboles collected in Arizona at the Lake Mead National Recreational Area at very low doses to represent environmental exposures. In this study, the fibrous amphibole asbestos sample from Arizona (AzA) is composed of winchite (69%), actinolite (22%), and non-amphibole minerals (9%) and has a mean aspect ratio of 16.7 ± 0.9. Fibrous amphibole asbestos from Libby (LAA) is composed of winchite (70%), richterite (9%), tremolite (5%), and non-amphibole minerals (16%) with a mean aspect ratio of 8.4 ± 0.7. C57BL/6 mice were exposed by oropharyngeal aspiration to fiber suspensions at a very low dose of 3 μg/mouse. After seven months, both LAA- and AzA-exposed mice had indices of chronic immune dysfunction related to a T{sub H}17 cytokine profile, with B cell activation, autoantibody production and proteinuria, suggesting kidney involvement. In addition, both exposures led to significant lung and pleural fibrosis. These data suggest that there is risk of pulmonary disease and autoimmune outcomes with environmental exposure to amphibole asbestos, and that this is not limited to Libby, Montana. - Highlights: • Health effects of Arizona versus Libby amphibole asbestos were comparable in mice. • Both fibers led to immune changes consistent with autoimmune dysfunction. • Both fibers caused significant increases in interstitial and pleural fibrosis. • Novel sources of asbestos could pose health risks even at low exposure levels.},
doi = {10.1016/J.TAAP.2017.08.022},
journal = {Toxicology and Applied Pharmacology},
issn = {0041-008X},
number = ,
volume = 334,
place = {United States},
year = {2017},
month = {11}
}