Folate receptor alpha is associated with cervical carcinogenesis and regulates cervical cancer cells growth by activating ERK1/2/c-Fos/c-Jun
- Department of Epidemiology, School of Public Health, Shanxi Medical University, Taiyuan 030001 (China)
- Maternal and Children Health Care Hospital of Shanxi Province Affiliated to Shanxi Medical University, Taiyuan 030013 (China)
- Department of Environmental Health, School of Public Health, Shanxi Medical University, Taiyuan 030001 (China)
Folate receptor alpha (FRα) is over-expressed in numerous epithelial malignancies, however, the association between FRα and cervical cancer remains unclear. The purpose of this study was to explore the effects of FRα on cervical cancer and its regulation of the ERK signaling pathway. In this case-control study, moderate/strong expression of FRα, phosphorylated ERK1/2 (p-ERK1/2), p-c-Fos, and p-c-Jun proteins was increased with the progressive severity of cervix lesions (P < 0.05). Moreover, the expression levels of p-ERK1/2, p-c-Fos, and p-c-Jun proteins was positively correlated with those of FRα protein in cervical squamous cell carcinoma (SCC) group (P < 0.05). In vitro experiment indicated down-regulation of FRα by siRNA suppressed cell proliferation, promoted cell apoptosis, induced cell cycle arrest at G0/G1 phase, and reduced expression of p-ERK1/2, p-c-Fos, and p-c-Jun proteins. The results suggest that FRα is associated with the progression of cervical cancer and regulates cervical cancer cells growth through phosphorylating ERK1/2, c-Fos, and c-Jun, which are key factors of the ERK signaling pathway. Therefore, FRα may be an effective target for early detection and therapy of cervical cancer. - Highlights: • FRα expression was increased with the progressive severity of cervix lesions. • FRα expression was positively correlated with that of p-ERK1/2, p-c-Fos, and p-c-Jun in cervical cancer. • Down-regulation of FRα expression suppressed cell proliferation and promoted apoptosis and cell cycle arrest. • Down-regulation of FRα expression reduced the expression of p-ERK1/2, p-c-Fos, and p-c-Jun.
- OSTI ID:
- 22719098
- Journal Information:
- Biochemical and Biophysical Research Communications, Vol. 491, Issue 4; Other Information: Copyright (c) 2017 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); ISSN 0006-291X
- Country of Publication:
- United States
- Language:
- English
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